{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2015:CVCDM7NLTCXZADM73OPRAQ4ITA","short_pith_number":"pith:CVCDM7NL","canonical_record":{"source":{"id":"1508.02786","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2015-08-12T00:41:13Z","cross_cats_sorted":["q-bio.SC"],"title_canon_sha256":"a276163aaab1d5462447078c3c44261436f22d187a65df7b3315126545271884","abstract_canon_sha256":"d660c652de2450bc36cae5fce27f6b43f991df852a9932af264b8ba1ebcf2891"},"schema_version":"1.0"},"canonical_sha256":"1544367dab98af900d9fdb9f104388983575a82a1ea289fd7245b3b68a328bac","source":{"kind":"arxiv","id":"1508.02786","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1508.02786","created_at":"2026-05-18T01:11:27Z"},{"alias_kind":"arxiv_version","alias_value":"1508.02786v2","created_at":"2026-05-18T01:11:27Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1508.02786","created_at":"2026-05-18T01:11:27Z"},{"alias_kind":"pith_short_12","alias_value":"CVCDM7NLTCXZ","created_at":"2026-05-18T12:29:17Z"},{"alias_kind":"pith_short_16","alias_value":"CVCDM7NLTCXZADM7","created_at":"2026-05-18T12:29:17Z"},{"alias_kind":"pith_short_8","alias_value":"CVCDM7NL","created_at":"2026-05-18T12:29:17Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2015:CVCDM7NLTCXZADM73OPRAQ4ITA","target":"record","payload":{"canonical_record":{"source":{"id":"1508.02786","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2015-08-12T00:41:13Z","cross_cats_sorted":["q-bio.SC"],"title_canon_sha256":"a276163aaab1d5462447078c3c44261436f22d187a65df7b3315126545271884","abstract_canon_sha256":"d660c652de2450bc36cae5fce27f6b43f991df852a9932af264b8ba1ebcf2891"},"schema_version":"1.0"},"canonical_sha256":"1544367dab98af900d9fdb9f104388983575a82a1ea289fd7245b3b68a328bac","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:11:27.309563Z","signature_b64":"vgvmKXjrv5MegqQDCPp4FFLSHzrXm3DiW4paPHA+Bny8cHiNfowUxhDDp2Q2z/0YORThW+wnCAPwXphswHuJBA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"1544367dab98af900d9fdb9f104388983575a82a1ea289fd7245b3b68a328bac","last_reissued_at":"2026-05-18T01:11:27.308864Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:11:27.308864Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1508.02786","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:11:27Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"vIo7q+raGgCNMXPJGMrE3fQneATmhV/edn93lZJzFnO85dXF6Fbcxx3cMI1GYuAnZSqROsUl3/oFangGXgsoBg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-02T01:18:41.431399Z"},"content_sha256":"2d447b3bca9014aec3e1c1d884964a2ccc1c0229fa103d66f36fdb5f13727eb2","schema_version":"1.0","event_id":"sha256:2d447b3bca9014aec3e1c1d884964a2ccc1c0229fa103d66f36fdb5f13727eb2"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2015:CVCDM7NLTCXZADM73OPRAQ4ITA","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Effects of 3D Geometries on Cellular Gradient Sensing and Polarization","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.SC"],"primary_cat":"physics.bio-ph","authors_text":"Fabian Spill, Michael Mak, Muhammad H. Zaman, Roger D. Kamm, Vivi Andasari","submitted_at":"2015-08-12T00:41:13Z","abstract_excerpt":"During cell migration, cells become polarized, change their shape, and move in response to various internal and external cues. Cell polarization is defined through the spatio-temporal organization of molecules such as PI3K or small GTPases, and is determined by intracellular signaling networks. It results in directional forces through actin polymerization and myosin contractions. Many existing mathematical models of cell polarization are formulated in terms of reaction-diffusion systems of interacting molecules, and are often defined in one or two spatial dimensions. In this paper, we introduc"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1508.02786","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:11:27Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"edNsUd9KYcS2ruiIlwpafJCzC/4Rf+v/Ag65rTUpHnZsQIR3NPBIr5zZDqkvYGfmw5+SfIPN41v0z4P8JmrVCQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-02T01:18:41.431748Z"},"content_sha256":"0722e52083988fa00055a99049aad723512759808b60fb41e899a9dd9ac4d247","schema_version":"1.0","event_id":"sha256:0722e52083988fa00055a99049aad723512759808b60fb41e899a9dd9ac4d247"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/CVCDM7NLTCXZADM73OPRAQ4ITA/bundle.json","state_url":"https://pith.science/pith/CVCDM7NLTCXZADM73OPRAQ4ITA/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/CVCDM7NLTCXZADM73OPRAQ4ITA/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-02T01:18:41Z","links":{"resolver":"https://pith.science/pith/CVCDM7NLTCXZADM73OPRAQ4ITA","bundle":"https://pith.science/pith/CVCDM7NLTCXZADM73OPRAQ4ITA/bundle.json","state":"https://pith.science/pith/CVCDM7NLTCXZADM73OPRAQ4ITA/state.json","well_known_bundle":"https://pith.science/.well-known/pith/CVCDM7NLTCXZADM73OPRAQ4ITA/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2015:CVCDM7NLTCXZADM73OPRAQ4ITA","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"d660c652de2450bc36cae5fce27f6b43f991df852a9932af264b8ba1ebcf2891","cross_cats_sorted":["q-bio.SC"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2015-08-12T00:41:13Z","title_canon_sha256":"a276163aaab1d5462447078c3c44261436f22d187a65df7b3315126545271884"},"schema_version":"1.0","source":{"id":"1508.02786","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1508.02786","created_at":"2026-05-18T01:11:27Z"},{"alias_kind":"arxiv_version","alias_value":"1508.02786v2","created_at":"2026-05-18T01:11:27Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1508.02786","created_at":"2026-05-18T01:11:27Z"},{"alias_kind":"pith_short_12","alias_value":"CVCDM7NLTCXZ","created_at":"2026-05-18T12:29:17Z"},{"alias_kind":"pith_short_16","alias_value":"CVCDM7NLTCXZADM7","created_at":"2026-05-18T12:29:17Z"},{"alias_kind":"pith_short_8","alias_value":"CVCDM7NL","created_at":"2026-05-18T12:29:17Z"}],"graph_snapshots":[{"event_id":"sha256:0722e52083988fa00055a99049aad723512759808b60fb41e899a9dd9ac4d247","target":"graph","created_at":"2026-05-18T01:11:27Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"During cell migration, cells become polarized, change their shape, and move in response to various internal and external cues. Cell polarization is defined through the spatio-temporal organization of molecules such as PI3K or small GTPases, and is determined by intracellular signaling networks. It results in directional forces through actin polymerization and myosin contractions. Many existing mathematical models of cell polarization are formulated in terms of reaction-diffusion systems of interacting molecules, and are often defined in one or two spatial dimensions. In this paper, we introduc","authors_text":"Fabian Spill, Michael Mak, Muhammad H. Zaman, Roger D. Kamm, Vivi Andasari","cross_cats":["q-bio.SC"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2015-08-12T00:41:13Z","title":"Effects of 3D Geometries on Cellular Gradient Sensing and Polarization"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1508.02786","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:2d447b3bca9014aec3e1c1d884964a2ccc1c0229fa103d66f36fdb5f13727eb2","target":"record","created_at":"2026-05-18T01:11:27Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"d660c652de2450bc36cae5fce27f6b43f991df852a9932af264b8ba1ebcf2891","cross_cats_sorted":["q-bio.SC"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2015-08-12T00:41:13Z","title_canon_sha256":"a276163aaab1d5462447078c3c44261436f22d187a65df7b3315126545271884"},"schema_version":"1.0","source":{"id":"1508.02786","kind":"arxiv","version":2}},"canonical_sha256":"1544367dab98af900d9fdb9f104388983575a82a1ea289fd7245b3b68a328bac","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"1544367dab98af900d9fdb9f104388983575a82a1ea289fd7245b3b68a328bac","first_computed_at":"2026-05-18T01:11:27.308864Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:11:27.308864Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"vgvmKXjrv5MegqQDCPp4FFLSHzrXm3DiW4paPHA+Bny8cHiNfowUxhDDp2Q2z/0YORThW+wnCAPwXphswHuJBA==","signature_status":"signed_v1","signed_at":"2026-05-18T01:11:27.309563Z","signed_message":"canonical_sha256_bytes"},"source_id":"1508.02786","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:2d447b3bca9014aec3e1c1d884964a2ccc1c0229fa103d66f36fdb5f13727eb2","sha256:0722e52083988fa00055a99049aad723512759808b60fb41e899a9dd9ac4d247"],"state_sha256":"ab79575bf2b09df6c7edb588b5fc5cafd6a20a3cb03acd97e7ee8790967425c0"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"jnNYdCfYg2qJEh2KrTaOB2ruRW0Hq4VA3pKqfNxCr9Cx+y2FL56JjC1xu4Li90wCAabbbQrUqBkj6d0LZBBlAA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-02T01:18:41.433949Z","bundle_sha256":"ee0f8d4b1be8fd0c90092cf23f858ea619456589acba5eb95119c7abb48a574f"}}