{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2024:CZDW2RKYHR7BO4EYSCDSWYBZXJ","short_pith_number":"pith:CZDW2RKY","schema_version":"1.0","canonical_sha256":"16476d45583c7e17709890872b6039ba785f3b728575b4bdf90f02fe95ed4129","source":{"kind":"arxiv","id":"2403.17226","version":1},"attestation_state":"computed","paper":{"title":"WIN-PDQ: A Wiener-estimator-based projection-domain quantitative SPECT method that accounts for intra-regional uptake heterogeneity","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"physics.med-ph","authors_text":"Abhinav K. Jha, Daniel L. J. Thorek, Nadia Benabdallah, Zekun Li","submitted_at":"2024-03-25T21:58:09Z","abstract_excerpt":"SPECT can enable the quantification of activity uptake in lesions and at-risk organs in {\\alpha}-particle-emitting radiopharmaceutical therapies ({\\alpha}-RPTs). But this quantification is challenged by the low photon counts, complicated isotope physics, and the image-degrading effects in {\\alpha}-RPT SPECT. Thus, strategies to optimize the SPECT system and protocol designs for the task of regional uptake quantification are needed. Objectively performing this task-based optimization requires a reliable (accurate and precise) regional uptake quantification method. Conventional reconstruction-ba"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"2403.17226","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2024-03-25T21:58:09Z","cross_cats_sorted":[],"title_canon_sha256":"cc58db2cd1dd8acd4ac8e68d6cfc88ee4e21b13ea12eceae88aa8992d9c61cd7","abstract_canon_sha256":"2d327f7ec5f968aab9ff3c4a57071beb0a6f7ae410937aac99f978060f78c067"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T08:00:46.846789Z","signature_b64":"uwNpA6ImgajkLOhIhj4EnSP7MaGhEL9+7ubpsEoBofORP7Cp61wFUXKZwwkkaDb4XtEVJJnGOCw0MB59zJYFDA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"16476d45583c7e17709890872b6039ba785f3b728575b4bdf90f02fe95ed4129","last_reissued_at":"2026-07-05T08:00:46.846389Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T08:00:46.846389Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"WIN-PDQ: A Wiener-estimator-based projection-domain quantitative SPECT method that accounts for intra-regional uptake heterogeneity","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"physics.med-ph","authors_text":"Abhinav K. Jha, Daniel L. J. Thorek, Nadia Benabdallah, Zekun Li","submitted_at":"2024-03-25T21:58:09Z","abstract_excerpt":"SPECT can enable the quantification of activity uptake in lesions and at-risk organs in {\\alpha}-particle-emitting radiopharmaceutical therapies ({\\alpha}-RPTs). But this quantification is challenged by the low photon counts, complicated isotope physics, and the image-degrading effects in {\\alpha}-RPT SPECT. Thus, strategies to optimize the SPECT system and protocol designs for the task of regional uptake quantification are needed. Objectively performing this task-based optimization requires a reliable (accurate and precise) regional uptake quantification method. Conventional reconstruction-ba"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2403.17226","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2403.17226/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"2403.17226","created_at":"2026-07-05T08:00:46.846447+00:00"},{"alias_kind":"arxiv_version","alias_value":"2403.17226v1","created_at":"2026-07-05T08:00:46.846447+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2403.17226","created_at":"2026-07-05T08:00:46.846447+00:00"},{"alias_kind":"pith_short_12","alias_value":"CZDW2RKYHR7B","created_at":"2026-07-05T08:00:46.846447+00:00"},{"alias_kind":"pith_short_16","alias_value":"CZDW2RKYHR7BO4EY","created_at":"2026-07-05T08:00:46.846447+00:00"},{"alias_kind":"pith_short_8","alias_value":"CZDW2RKY","created_at":"2026-07-05T08:00:46.846447+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/CZDW2RKYHR7BO4EYSCDSWYBZXJ","json":"https://pith.science/pith/CZDW2RKYHR7BO4EYSCDSWYBZXJ.json","graph_json":"https://pith.science/api/pith-number/CZDW2RKYHR7BO4EYSCDSWYBZXJ/graph.json","events_json":"https://pith.science/api/pith-number/CZDW2RKYHR7BO4EYSCDSWYBZXJ/events.json","paper":"https://pith.science/paper/CZDW2RKY"},"agent_actions":{"view_html":"https://pith.science/pith/CZDW2RKYHR7BO4EYSCDSWYBZXJ","download_json":"https://pith.science/pith/CZDW2RKYHR7BO4EYSCDSWYBZXJ.json","view_paper":"https://pith.science/paper/CZDW2RKY","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=2403.17226&json=true","fetch_graph":"https://pith.science/api/pith-number/CZDW2RKYHR7BO4EYSCDSWYBZXJ/graph.json","fetch_events":"https://pith.science/api/pith-number/CZDW2RKYHR7BO4EYSCDSWYBZXJ/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/CZDW2RKYHR7BO4EYSCDSWYBZXJ/action/timestamp_anchor","attest_storage":"https://pith.science/pith/CZDW2RKYHR7BO4EYSCDSWYBZXJ/action/storage_attestation","attest_author":"https://pith.science/pith/CZDW2RKYHR7BO4EYSCDSWYBZXJ/action/author_attestation","sign_citation":"https://pith.science/pith/CZDW2RKYHR7BO4EYSCDSWYBZXJ/action/citation_signature","submit_replication":"https://pith.science/pith/CZDW2RKYHR7BO4EYSCDSWYBZXJ/action/replication_record"}},"created_at":"2026-07-05T08:00:46.846447+00:00","updated_at":"2026-07-05T08:00:46.846447+00:00"}