{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2015:D2AGANLMV33BGXJO4GAWYOXMJZ","short_pith_number":"pith:D2AGANLM","canonical_record":{"source":{"id":"1512.00268","kind":"arxiv","version":4},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2015-12-01T14:24:29Z","cross_cats_sorted":["q-bio.GN"],"title_canon_sha256":"6fe4a48f1d10262c735f8c2b364ab173d9741f19d820ef59a932ea02d4127625","abstract_canon_sha256":"5ac17b3475791423eea83f3fd3bf7c6a3a1dd22c4eb8be2d50af80aae5b4a1ac"},"schema_version":"1.0"},"canonical_sha256":"1e8060356caef6135d2ee1816c3aec4e6d75164fdf882d5aa74469df9e70c297","source":{"kind":"arxiv","id":"1512.00268","version":4},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1512.00268","created_at":"2026-05-18T01:13:23Z"},{"alias_kind":"arxiv_version","alias_value":"1512.00268v4","created_at":"2026-05-18T01:13:23Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1512.00268","created_at":"2026-05-18T01:13:23Z"},{"alias_kind":"pith_short_12","alias_value":"D2AGANLMV33B","created_at":"2026-05-18T12:29:17Z"},{"alias_kind":"pith_short_16","alias_value":"D2AGANLMV33BGXJO","created_at":"2026-05-18T12:29:17Z"},{"alias_kind":"pith_short_8","alias_value":"D2AGANLM","created_at":"2026-05-18T12:29:17Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2015:D2AGANLMV33BGXJO4GAWYOXMJZ","target":"record","payload":{"canonical_record":{"source":{"id":"1512.00268","kind":"arxiv","version":4},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2015-12-01T14:24:29Z","cross_cats_sorted":["q-bio.GN"],"title_canon_sha256":"6fe4a48f1d10262c735f8c2b364ab173d9741f19d820ef59a932ea02d4127625","abstract_canon_sha256":"5ac17b3475791423eea83f3fd3bf7c6a3a1dd22c4eb8be2d50af80aae5b4a1ac"},"schema_version":"1.0"},"canonical_sha256":"1e8060356caef6135d2ee1816c3aec4e6d75164fdf882d5aa74469df9e70c297","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:13:23.900468Z","signature_b64":"ByrGx/4II7nngQJjZr/z73z6si9sMfmp72cA40UZKMoC5tN6BLEc0MZUVX4dXE7wZufJJ60tPfchgJwNx6pqBA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"1e8060356caef6135d2ee1816c3aec4e6d75164fdf882d5aa74469df9e70c297","last_reissued_at":"2026-05-18T01:13:23.900034Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:13:23.900034Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1512.00268","source_version":4,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:13:23Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"oh04puRbux27KUzvd+tSykm++SAF8L6qXBnSN4KNqF2QJ1XCMS/yqDRJ38yNIvwd6XnRUUK2tSzUOst7FK+oAg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-31T11:23:42.115682Z"},"content_sha256":"a9ebaa66a5b76e5fe4b95a654a5be68252a2f6c20a392a28ef8c28c710b07208","schema_version":"1.0","event_id":"sha256:a9ebaa66a5b76e5fe4b95a654a5be68252a2f6c20a392a28ef8c28c710b07208"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2015:D2AGANLMV33BGXJO4GAWYOXMJZ","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Integrating epigenomic data and 3D genomic structure with a new measure of chromatin assortativity","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.GN"],"primary_cat":"q-bio.MN","authors_text":"Alfonso Valencia, Biola Maria Javierre, Daniel Rico, David Juan, Enrique Carrillo-de-Santa-Pau, Mikhail Spivakov, Peter Fraser, Vera Pancaldi","submitted_at":"2015-12-01T14:24:29Z","abstract_excerpt":"Network analysis is a powerful way of modeling chromatin interactions. Assortativity is a network property used in social sciences to identify factors affecting how people establish social ties. We propose a new approach, using chromatin assortativity to integrate the epigenomic landscape of a specific cell type with its chromatin interaction network and thus investigate which proteins or chromatin marks mediate genomic contacts. We use high-resolution Promoter Capture Hi-C and Hi-Cap data as well as ChIA-PET data from mouse embryonic stem cells to investigate promoter-centered chromatin inter"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1512.00268","kind":"arxiv","version":4},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:13:23Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Othq0U36YWyGQA+GgRSZy5/b+k2krouqSXPrIQgryEwUNAUF7v5uN4SlwquyI4GL7/NxNKs8ivm1Da+FyXiPBg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-31T11:23:42.116339Z"},"content_sha256":"58494db2562b57174794d798b41b335f551a1cf3ae9cc36dc9ba4d5d1fc4b69f","schema_version":"1.0","event_id":"sha256:58494db2562b57174794d798b41b335f551a1cf3ae9cc36dc9ba4d5d1fc4b69f"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/D2AGANLMV33BGXJO4GAWYOXMJZ/bundle.json","state_url":"https://pith.science/pith/D2AGANLMV33BGXJO4GAWYOXMJZ/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/D2AGANLMV33BGXJO4GAWYOXMJZ/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-31T11:23:42Z","links":{"resolver":"https://pith.science/pith/D2AGANLMV33BGXJO4GAWYOXMJZ","bundle":"https://pith.science/pith/D2AGANLMV33BGXJO4GAWYOXMJZ/bundle.json","state":"https://pith.science/pith/D2AGANLMV33BGXJO4GAWYOXMJZ/state.json","well_known_bundle":"https://pith.science/.well-known/pith/D2AGANLMV33BGXJO4GAWYOXMJZ/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2015:D2AGANLMV33BGXJO4GAWYOXMJZ","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"5ac17b3475791423eea83f3fd3bf7c6a3a1dd22c4eb8be2d50af80aae5b4a1ac","cross_cats_sorted":["q-bio.GN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2015-12-01T14:24:29Z","title_canon_sha256":"6fe4a48f1d10262c735f8c2b364ab173d9741f19d820ef59a932ea02d4127625"},"schema_version":"1.0","source":{"id":"1512.00268","kind":"arxiv","version":4}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1512.00268","created_at":"2026-05-18T01:13:23Z"},{"alias_kind":"arxiv_version","alias_value":"1512.00268v4","created_at":"2026-05-18T01:13:23Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1512.00268","created_at":"2026-05-18T01:13:23Z"},{"alias_kind":"pith_short_12","alias_value":"D2AGANLMV33B","created_at":"2026-05-18T12:29:17Z"},{"alias_kind":"pith_short_16","alias_value":"D2AGANLMV33BGXJO","created_at":"2026-05-18T12:29:17Z"},{"alias_kind":"pith_short_8","alias_value":"D2AGANLM","created_at":"2026-05-18T12:29:17Z"}],"graph_snapshots":[{"event_id":"sha256:58494db2562b57174794d798b41b335f551a1cf3ae9cc36dc9ba4d5d1fc4b69f","target":"graph","created_at":"2026-05-18T01:13:23Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Network analysis is a powerful way of modeling chromatin interactions. Assortativity is a network property used in social sciences to identify factors affecting how people establish social ties. We propose a new approach, using chromatin assortativity to integrate the epigenomic landscape of a specific cell type with its chromatin interaction network and thus investigate which proteins or chromatin marks mediate genomic contacts. We use high-resolution Promoter Capture Hi-C and Hi-Cap data as well as ChIA-PET data from mouse embryonic stem cells to investigate promoter-centered chromatin inter","authors_text":"Alfonso Valencia, Biola Maria Javierre, Daniel Rico, David Juan, Enrique Carrillo-de-Santa-Pau, Mikhail Spivakov, Peter Fraser, Vera Pancaldi","cross_cats":["q-bio.GN"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2015-12-01T14:24:29Z","title":"Integrating epigenomic data and 3D genomic structure with a new measure of chromatin assortativity"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1512.00268","kind":"arxiv","version":4},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:a9ebaa66a5b76e5fe4b95a654a5be68252a2f6c20a392a28ef8c28c710b07208","target":"record","created_at":"2026-05-18T01:13:23Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"5ac17b3475791423eea83f3fd3bf7c6a3a1dd22c4eb8be2d50af80aae5b4a1ac","cross_cats_sorted":["q-bio.GN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2015-12-01T14:24:29Z","title_canon_sha256":"6fe4a48f1d10262c735f8c2b364ab173d9741f19d820ef59a932ea02d4127625"},"schema_version":"1.0","source":{"id":"1512.00268","kind":"arxiv","version":4}},"canonical_sha256":"1e8060356caef6135d2ee1816c3aec4e6d75164fdf882d5aa74469df9e70c297","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"1e8060356caef6135d2ee1816c3aec4e6d75164fdf882d5aa74469df9e70c297","first_computed_at":"2026-05-18T01:13:23.900034Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:13:23.900034Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"ByrGx/4II7nngQJjZr/z73z6si9sMfmp72cA40UZKMoC5tN6BLEc0MZUVX4dXE7wZufJJ60tPfchgJwNx6pqBA==","signature_status":"signed_v1","signed_at":"2026-05-18T01:13:23.900468Z","signed_message":"canonical_sha256_bytes"},"source_id":"1512.00268","source_kind":"arxiv","source_version":4}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:a9ebaa66a5b76e5fe4b95a654a5be68252a2f6c20a392a28ef8c28c710b07208","sha256:58494db2562b57174794d798b41b335f551a1cf3ae9cc36dc9ba4d5d1fc4b69f"],"state_sha256":"1c37ee3dd8657ca8937082166e1cd83b2cbbf63651f6e0386435eedff47060e7"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"4Ap5N3EjpunxMQwveyXHcyrVQcQp3nBCKIcfFMzPP68O2KpxVQKGCB1WCHV5jxIA9Av+ch4Gv4zIR5I1msnnCA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-31T11:23:42.120039Z","bundle_sha256":"f53a45649a69791a3e6f181567588571ab65a21efb5e0a11a202a4811e777c3e"}}