{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2023:D4AAYVQIUJRSJZYNP45UH4RCP3","short_pith_number":"pith:D4AAYVQI","canonical_record":{"source":{"id":"2308.02062","kind":"arxiv","version":2},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"eess.IV","submitted_at":"2023-08-03T21:56:50Z","cross_cats_sorted":["cs.CV"],"title_canon_sha256":"fdf67996beaeaba123940cb3198b0f349f31a553258992b1aa465209a9aee6aa","abstract_canon_sha256":"cc90f736fff11e2c3b410b6ba68892f3f06196ae5d0e0055542535e3a3d33074"},"schema_version":"1.0"},"canonical_sha256":"1f000c5608a26324e70d7f3b43f2227ef737bff85a0186e1a12fba4a99833837","source":{"kind":"arxiv","id":"2308.02062","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2308.02062","created_at":"2026-07-05T09:13:47Z"},{"alias_kind":"arxiv_version","alias_value":"2308.02062v2","created_at":"2026-07-05T09:13:47Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2308.02062","created_at":"2026-07-05T09:13:47Z"},{"alias_kind":"pith_short_12","alias_value":"D4AAYVQIUJRS","created_at":"2026-07-05T09:13:47Z"},{"alias_kind":"pith_short_16","alias_value":"D4AAYVQIUJRSJZYN","created_at":"2026-07-05T09:13:47Z"},{"alias_kind":"pith_short_8","alias_value":"D4AAYVQI","created_at":"2026-07-05T09:13:47Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2023:D4AAYVQIUJRSJZYNP45UH4RCP3","target":"record","payload":{"canonical_record":{"source":{"id":"2308.02062","kind":"arxiv","version":2},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"eess.IV","submitted_at":"2023-08-03T21:56:50Z","cross_cats_sorted":["cs.CV"],"title_canon_sha256":"fdf67996beaeaba123940cb3198b0f349f31a553258992b1aa465209a9aee6aa","abstract_canon_sha256":"cc90f736fff11e2c3b410b6ba68892f3f06196ae5d0e0055542535e3a3d33074"},"schema_version":"1.0"},"canonical_sha256":"1f000c5608a26324e70d7f3b43f2227ef737bff85a0186e1a12fba4a99833837","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T09:13:47.391210Z","signature_b64":"zh2Gqv8aTllkttAHGV+ytrylUvUaH6OFnsYrWA55nDPdM1FUdadkMLQbEIccP98cNB9K/7Y6NGgl6AQWybacAw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"1f000c5608a26324e70d7f3b43f2227ef737bff85a0186e1a12fba4a99833837","last_reissued_at":"2026-07-05T09:13:47.390724Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T09:13:47.390724Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2308.02062","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T09:13:47Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"kEDjZgQyg7f6p1CuwwafopGIaftCuJfC6t81oWZEeTOqRIMED8B3C+EoDopx8cwU2Rz5O9MnR1VjWPZdS5RuCg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-31T19:47:56.062454Z"},"content_sha256":"dcdbd01df92d8ac0ad03ddb54ff7236a6d116d336a9447b6772f18f78d7bc8af","schema_version":"1.0","event_id":"sha256:dcdbd01df92d8ac0ad03ddb54ff7236a6d116d336a9447b6772f18f78d7bc8af"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2023:D4AAYVQIUJRSJZYNP45UH4RCP3","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Diffusion Models for Counterfactual Generation and Anomaly Detection in Brain Images","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["cs.CV"],"primary_cat":"eess.IV","authors_text":"Alessandro Fontanella, Amos Storkey, Emanuele Trucco, Grant Mair, Joanna Wardlaw","submitted_at":"2023-08-03T21:56:50Z","abstract_excerpt":"Segmentation masks of pathological areas are useful in many medical applications, such as brain tumour and stroke management. Moreover, healthy counterfactuals of diseased images can be used to enhance radiologists' training files and to improve the interpretability of segmentation models. In this work, we present a weakly supervised method to generate a healthy version of a diseased image and then use it to obtain a pixel-wise anomaly map. To do so, we start by considering a saliency map that approximately covers the pathological areas, obtained with ACAT. Then, we propose a technique that al"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2308.02062","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2308.02062/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T09:13:47Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"3t+S3zsw452numerqnSfJun0evHDkXb0z5GBXFuaJt1bRlCby1rOG/VZMga1aqStDAzLxzxHSYH8MYtB3M0jCg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-31T19:47:56.062963Z"},"content_sha256":"c913661ceacba54f4f8b02cf2abd1cc65cde90f204c0f9188432392c51598aa6","schema_version":"1.0","event_id":"sha256:c913661ceacba54f4f8b02cf2abd1cc65cde90f204c0f9188432392c51598aa6"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/D4AAYVQIUJRSJZYNP45UH4RCP3/bundle.json","state_url":"https://pith.science/pith/D4AAYVQIUJRSJZYNP45UH4RCP3/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/D4AAYVQIUJRSJZYNP45UH4RCP3/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-07-31T19:47:56Z","links":{"resolver":"https://pith.science/pith/D4AAYVQIUJRSJZYNP45UH4RCP3","bundle":"https://pith.science/pith/D4AAYVQIUJRSJZYNP45UH4RCP3/bundle.json","state":"https://pith.science/pith/D4AAYVQIUJRSJZYNP45UH4RCP3/state.json","well_known_bundle":"https://pith.science/.well-known/pith/D4AAYVQIUJRSJZYNP45UH4RCP3/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2023:D4AAYVQIUJRSJZYNP45UH4RCP3","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"cc90f736fff11e2c3b410b6ba68892f3f06196ae5d0e0055542535e3a3d33074","cross_cats_sorted":["cs.CV"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"eess.IV","submitted_at":"2023-08-03T21:56:50Z","title_canon_sha256":"fdf67996beaeaba123940cb3198b0f349f31a553258992b1aa465209a9aee6aa"},"schema_version":"1.0","source":{"id":"2308.02062","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2308.02062","created_at":"2026-07-05T09:13:47Z"},{"alias_kind":"arxiv_version","alias_value":"2308.02062v2","created_at":"2026-07-05T09:13:47Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2308.02062","created_at":"2026-07-05T09:13:47Z"},{"alias_kind":"pith_short_12","alias_value":"D4AAYVQIUJRS","created_at":"2026-07-05T09:13:47Z"},{"alias_kind":"pith_short_16","alias_value":"D4AAYVQIUJRSJZYN","created_at":"2026-07-05T09:13:47Z"},{"alias_kind":"pith_short_8","alias_value":"D4AAYVQI","created_at":"2026-07-05T09:13:47Z"}],"graph_snapshots":[{"event_id":"sha256:c913661ceacba54f4f8b02cf2abd1cc65cde90f204c0f9188432392c51598aa6","target":"graph","created_at":"2026-07-05T09:13:47Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2308.02062/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Segmentation masks of pathological areas are useful in many medical applications, such as brain tumour and stroke management. Moreover, healthy counterfactuals of diseased images can be used to enhance radiologists' training files and to improve the interpretability of segmentation models. In this work, we present a weakly supervised method to generate a healthy version of a diseased image and then use it to obtain a pixel-wise anomaly map. To do so, we start by considering a saliency map that approximately covers the pathological areas, obtained with ACAT. Then, we propose a technique that al","authors_text":"Alessandro Fontanella, Amos Storkey, Emanuele Trucco, Grant Mair, Joanna Wardlaw","cross_cats":["cs.CV"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"eess.IV","submitted_at":"2023-08-03T21:56:50Z","title":"Diffusion Models for Counterfactual Generation and Anomaly Detection in Brain Images"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2308.02062","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:dcdbd01df92d8ac0ad03ddb54ff7236a6d116d336a9447b6772f18f78d7bc8af","target":"record","created_at":"2026-07-05T09:13:47Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"cc90f736fff11e2c3b410b6ba68892f3f06196ae5d0e0055542535e3a3d33074","cross_cats_sorted":["cs.CV"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"eess.IV","submitted_at":"2023-08-03T21:56:50Z","title_canon_sha256":"fdf67996beaeaba123940cb3198b0f349f31a553258992b1aa465209a9aee6aa"},"schema_version":"1.0","source":{"id":"2308.02062","kind":"arxiv","version":2}},"canonical_sha256":"1f000c5608a26324e70d7f3b43f2227ef737bff85a0186e1a12fba4a99833837","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"1f000c5608a26324e70d7f3b43f2227ef737bff85a0186e1a12fba4a99833837","first_computed_at":"2026-07-05T09:13:47.390724Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T09:13:47.390724Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"zh2Gqv8aTllkttAHGV+ytrylUvUaH6OFnsYrWA55nDPdM1FUdadkMLQbEIccP98cNB9K/7Y6NGgl6AQWybacAw==","signature_status":"signed_v1","signed_at":"2026-07-05T09:13:47.391210Z","signed_message":"canonical_sha256_bytes"},"source_id":"2308.02062","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:dcdbd01df92d8ac0ad03ddb54ff7236a6d116d336a9447b6772f18f78d7bc8af","sha256:c913661ceacba54f4f8b02cf2abd1cc65cde90f204c0f9188432392c51598aa6"],"state_sha256":"f1c24dacbd886da0a6352f186add05013669aef28df17cf3ce27eb414731733b"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"rqpjcS+/6+sxDHITbGP9Dn+owqiIm6uhsoI0sNjHmKD6vHRheYG9TjIx/RPSxSzXVuR1GwGJDDfk2JjubGgnDg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-07-31T19:47:56.068983Z","bundle_sha256":"4e1ab70289581b69caaa1019fac7ae462dd8a65151eaa44b43a0c5456df4e637"}}