{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2018:D53HL6O4EHWBBI35V6DIR62SZA","short_pith_number":"pith:D53HL6O4","schema_version":"1.0","canonical_sha256":"1f7675f9dc21ec10a37daf8688fb52c81ed1b911f94ffef85862426beca44402","source":{"kind":"arxiv","id":"1802.02066","version":1},"attestation_state":"computed","paper":{"title":"Fidelity of bacterial translation initiation: a stochastic kinetic model","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.chem-ph","q-bio.SC"],"primary_cat":"physics.bio-ph","authors_text":"(2) Columbia University), Debashish Chowdhury (1) ((1) IIT Kanpur, Dipanwita Ghanti (1), Joachim Frank (2), Jr. (2), Kelvin Caban (2), Ruben L. Gonzalez","submitted_at":"2018-02-06T16:52:15Z","abstract_excerpt":"During the initiation stage of protein synthesis, a ribosomal initiation complex (IC) is assembled on a messenger RNA (mRNA) template. In bacteria, the speed and accuracy of this assembly process are regulated by the complementary activities of three essential initiation factors (IFs). Selection of an authentic N-formylmethionyl-transfer RNA (fMet-tRNA\\textsuperscript{fMet}) and the canonical, triplet-nucleotide mRNA start codon are crucial events during assembly of a canonical, ribosomal 70S IC. Mis-initiation due to the aberrant selection of an elongator tRNA or a non-canonical start codon a"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1802.02066","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2018-02-06T16:52:15Z","cross_cats_sorted":["physics.chem-ph","q-bio.SC"],"title_canon_sha256":"48c0665a0ad32b893d6d8bce5d89e181689838ea49bd195034d2c6cf5b214acf","abstract_canon_sha256":"415e846247566818dc214bb22c994cad5bd2b501a1ee8690152d397b190a69bd"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:24:10.995526Z","signature_b64":"Y0awxNFSPi66YltgTv5MouytycDhZ7OzwNvNC2YDkZ/ouZsJbtGlT5N0VUrGLd8IrwhzkCi60Or4YdRSCDYmBw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"1f7675f9dc21ec10a37daf8688fb52c81ed1b911f94ffef85862426beca44402","last_reissued_at":"2026-05-18T00:24:10.994849Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:24:10.994849Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Fidelity of bacterial translation initiation: a stochastic kinetic model","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.chem-ph","q-bio.SC"],"primary_cat":"physics.bio-ph","authors_text":"(2) Columbia University), Debashish Chowdhury (1) ((1) IIT Kanpur, Dipanwita Ghanti (1), Joachim Frank (2), Jr. (2), Kelvin Caban (2), Ruben L. Gonzalez","submitted_at":"2018-02-06T16:52:15Z","abstract_excerpt":"During the initiation stage of protein synthesis, a ribosomal initiation complex (IC) is assembled on a messenger RNA (mRNA) template. In bacteria, the speed and accuracy of this assembly process are regulated by the complementary activities of three essential initiation factors (IFs). Selection of an authentic N-formylmethionyl-transfer RNA (fMet-tRNA\\textsuperscript{fMet}) and the canonical, triplet-nucleotide mRNA start codon are crucial events during assembly of a canonical, ribosomal 70S IC. Mis-initiation due to the aberrant selection of an elongator tRNA or a non-canonical start codon a"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1802.02066","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1802.02066","created_at":"2026-05-18T00:24:10.994948+00:00"},{"alias_kind":"arxiv_version","alias_value":"1802.02066v1","created_at":"2026-05-18T00:24:10.994948+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1802.02066","created_at":"2026-05-18T00:24:10.994948+00:00"},{"alias_kind":"pith_short_12","alias_value":"D53HL6O4EHWB","created_at":"2026-05-18T12:32:19.392346+00:00"},{"alias_kind":"pith_short_16","alias_value":"D53HL6O4EHWBBI35","created_at":"2026-05-18T12:32:19.392346+00:00"},{"alias_kind":"pith_short_8","alias_value":"D53HL6O4","created_at":"2026-05-18T12:32:19.392346+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/D53HL6O4EHWBBI35V6DIR62SZA","json":"https://pith.science/pith/D53HL6O4EHWBBI35V6DIR62SZA.json","graph_json":"https://pith.science/api/pith-number/D53HL6O4EHWBBI35V6DIR62SZA/graph.json","events_json":"https://pith.science/api/pith-number/D53HL6O4EHWBBI35V6DIR62SZA/events.json","paper":"https://pith.science/paper/D53HL6O4"},"agent_actions":{"view_html":"https://pith.science/pith/D53HL6O4EHWBBI35V6DIR62SZA","download_json":"https://pith.science/pith/D53HL6O4EHWBBI35V6DIR62SZA.json","view_paper":"https://pith.science/paper/D53HL6O4","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1802.02066&json=true","fetch_graph":"https://pith.science/api/pith-number/D53HL6O4EHWBBI35V6DIR62SZA/graph.json","fetch_events":"https://pith.science/api/pith-number/D53HL6O4EHWBBI35V6DIR62SZA/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/D53HL6O4EHWBBI35V6DIR62SZA/action/timestamp_anchor","attest_storage":"https://pith.science/pith/D53HL6O4EHWBBI35V6DIR62SZA/action/storage_attestation","attest_author":"https://pith.science/pith/D53HL6O4EHWBBI35V6DIR62SZA/action/author_attestation","sign_citation":"https://pith.science/pith/D53HL6O4EHWBBI35V6DIR62SZA/action/citation_signature","submit_replication":"https://pith.science/pith/D53HL6O4EHWBBI35V6DIR62SZA/action/replication_record"}},"created_at":"2026-05-18T00:24:10.994948+00:00","updated_at":"2026-05-18T00:24:10.994948+00:00"}