{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2018:D53HL6O4EHWBBI35V6DIR62SZA","short_pith_number":"pith:D53HL6O4","canonical_record":{"source":{"id":"1802.02066","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2018-02-06T16:52:15Z","cross_cats_sorted":["physics.chem-ph","q-bio.SC"],"title_canon_sha256":"48c0665a0ad32b893d6d8bce5d89e181689838ea49bd195034d2c6cf5b214acf","abstract_canon_sha256":"415e846247566818dc214bb22c994cad5bd2b501a1ee8690152d397b190a69bd"},"schema_version":"1.0"},"canonical_sha256":"1f7675f9dc21ec10a37daf8688fb52c81ed1b911f94ffef85862426beca44402","source":{"kind":"arxiv","id":"1802.02066","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1802.02066","created_at":"2026-05-18T00:24:10Z"},{"alias_kind":"arxiv_version","alias_value":"1802.02066v1","created_at":"2026-05-18T00:24:10Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1802.02066","created_at":"2026-05-18T00:24:10Z"},{"alias_kind":"pith_short_12","alias_value":"D53HL6O4EHWB","created_at":"2026-05-18T12:32:19Z"},{"alias_kind":"pith_short_16","alias_value":"D53HL6O4EHWBBI35","created_at":"2026-05-18T12:32:19Z"},{"alias_kind":"pith_short_8","alias_value":"D53HL6O4","created_at":"2026-05-18T12:32:19Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2018:D53HL6O4EHWBBI35V6DIR62SZA","target":"record","payload":{"canonical_record":{"source":{"id":"1802.02066","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2018-02-06T16:52:15Z","cross_cats_sorted":["physics.chem-ph","q-bio.SC"],"title_canon_sha256":"48c0665a0ad32b893d6d8bce5d89e181689838ea49bd195034d2c6cf5b214acf","abstract_canon_sha256":"415e846247566818dc214bb22c994cad5bd2b501a1ee8690152d397b190a69bd"},"schema_version":"1.0"},"canonical_sha256":"1f7675f9dc21ec10a37daf8688fb52c81ed1b911f94ffef85862426beca44402","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:24:10.995526Z","signature_b64":"Y0awxNFSPi66YltgTv5MouytycDhZ7OzwNvNC2YDkZ/ouZsJbtGlT5N0VUrGLd8IrwhzkCi60Or4YdRSCDYmBw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"1f7675f9dc21ec10a37daf8688fb52c81ed1b911f94ffef85862426beca44402","last_reissued_at":"2026-05-18T00:24:10.994849Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:24:10.994849Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1802.02066","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:24:10Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"ZfwRIn4EjmKij8YHEC7fWzDi7CUPKqXvdaSWajiLLrv7QxYNY3L6x6vyHi60IcupEBd1StGP0aWJr+g5VhKTBg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-24T12:21:29.053138Z"},"content_sha256":"df0751e25f8b7ba521515eb33d51a3d4ec0b154fa7353dc54dc675631587518f","schema_version":"1.0","event_id":"sha256:df0751e25f8b7ba521515eb33d51a3d4ec0b154fa7353dc54dc675631587518f"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2018:D53HL6O4EHWBBI35V6DIR62SZA","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Fidelity of bacterial translation initiation: a stochastic kinetic model","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.chem-ph","q-bio.SC"],"primary_cat":"physics.bio-ph","authors_text":"(2) Columbia University), Debashish Chowdhury (1) ((1) IIT Kanpur, Dipanwita Ghanti (1), Joachim Frank (2), Jr. (2), Kelvin Caban (2), Ruben L. Gonzalez","submitted_at":"2018-02-06T16:52:15Z","abstract_excerpt":"During the initiation stage of protein synthesis, a ribosomal initiation complex (IC) is assembled on a messenger RNA (mRNA) template. In bacteria, the speed and accuracy of this assembly process are regulated by the complementary activities of three essential initiation factors (IFs). Selection of an authentic N-formylmethionyl-transfer RNA (fMet-tRNA\\textsuperscript{fMet}) and the canonical, triplet-nucleotide mRNA start codon are crucial events during assembly of a canonical, ribosomal 70S IC. Mis-initiation due to the aberrant selection of an elongator tRNA or a non-canonical start codon a"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1802.02066","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:24:10Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"4BuWcx4NKNokbXBRGOv959qqmAOhma3VV58vrWUaFrCmKJF+CA0WRWdeWr75UOc02i7Q4/WY54f2G085zynJAw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-24T12:21:29.053850Z"},"content_sha256":"4dc0628d453f4a3ee6a97e1794132a350cc8a7c36bd4c3a7533ba3c876f7b52c","schema_version":"1.0","event_id":"sha256:4dc0628d453f4a3ee6a97e1794132a350cc8a7c36bd4c3a7533ba3c876f7b52c"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/D53HL6O4EHWBBI35V6DIR62SZA/bundle.json","state_url":"https://pith.science/pith/D53HL6O4EHWBBI35V6DIR62SZA/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/D53HL6O4EHWBBI35V6DIR62SZA/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-24T12:21:29Z","links":{"resolver":"https://pith.science/pith/D53HL6O4EHWBBI35V6DIR62SZA","bundle":"https://pith.science/pith/D53HL6O4EHWBBI35V6DIR62SZA/bundle.json","state":"https://pith.science/pith/D53HL6O4EHWBBI35V6DIR62SZA/state.json","well_known_bundle":"https://pith.science/.well-known/pith/D53HL6O4EHWBBI35V6DIR62SZA/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2018:D53HL6O4EHWBBI35V6DIR62SZA","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"415e846247566818dc214bb22c994cad5bd2b501a1ee8690152d397b190a69bd","cross_cats_sorted":["physics.chem-ph","q-bio.SC"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2018-02-06T16:52:15Z","title_canon_sha256":"48c0665a0ad32b893d6d8bce5d89e181689838ea49bd195034d2c6cf5b214acf"},"schema_version":"1.0","source":{"id":"1802.02066","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1802.02066","created_at":"2026-05-18T00:24:10Z"},{"alias_kind":"arxiv_version","alias_value":"1802.02066v1","created_at":"2026-05-18T00:24:10Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1802.02066","created_at":"2026-05-18T00:24:10Z"},{"alias_kind":"pith_short_12","alias_value":"D53HL6O4EHWB","created_at":"2026-05-18T12:32:19Z"},{"alias_kind":"pith_short_16","alias_value":"D53HL6O4EHWBBI35","created_at":"2026-05-18T12:32:19Z"},{"alias_kind":"pith_short_8","alias_value":"D53HL6O4","created_at":"2026-05-18T12:32:19Z"}],"graph_snapshots":[{"event_id":"sha256:4dc0628d453f4a3ee6a97e1794132a350cc8a7c36bd4c3a7533ba3c876f7b52c","target":"graph","created_at":"2026-05-18T00:24:10Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"During the initiation stage of protein synthesis, a ribosomal initiation complex (IC) is assembled on a messenger RNA (mRNA) template. In bacteria, the speed and accuracy of this assembly process are regulated by the complementary activities of three essential initiation factors (IFs). Selection of an authentic N-formylmethionyl-transfer RNA (fMet-tRNA\\textsuperscript{fMet}) and the canonical, triplet-nucleotide mRNA start codon are crucial events during assembly of a canonical, ribosomal 70S IC. Mis-initiation due to the aberrant selection of an elongator tRNA or a non-canonical start codon a","authors_text":"(2) Columbia University), Debashish Chowdhury (1) ((1) IIT Kanpur, Dipanwita Ghanti (1), Joachim Frank (2), Jr. (2), Kelvin Caban (2), Ruben L. Gonzalez","cross_cats":["physics.chem-ph","q-bio.SC"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2018-02-06T16:52:15Z","title":"Fidelity of bacterial translation initiation: a stochastic kinetic model"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1802.02066","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:df0751e25f8b7ba521515eb33d51a3d4ec0b154fa7353dc54dc675631587518f","target":"record","created_at":"2026-05-18T00:24:10Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"415e846247566818dc214bb22c994cad5bd2b501a1ee8690152d397b190a69bd","cross_cats_sorted":["physics.chem-ph","q-bio.SC"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2018-02-06T16:52:15Z","title_canon_sha256":"48c0665a0ad32b893d6d8bce5d89e181689838ea49bd195034d2c6cf5b214acf"},"schema_version":"1.0","source":{"id":"1802.02066","kind":"arxiv","version":1}},"canonical_sha256":"1f7675f9dc21ec10a37daf8688fb52c81ed1b911f94ffef85862426beca44402","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"1f7675f9dc21ec10a37daf8688fb52c81ed1b911f94ffef85862426beca44402","first_computed_at":"2026-05-18T00:24:10.994849Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:24:10.994849Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"Y0awxNFSPi66YltgTv5MouytycDhZ7OzwNvNC2YDkZ/ouZsJbtGlT5N0VUrGLd8IrwhzkCi60Or4YdRSCDYmBw==","signature_status":"signed_v1","signed_at":"2026-05-18T00:24:10.995526Z","signed_message":"canonical_sha256_bytes"},"source_id":"1802.02066","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:df0751e25f8b7ba521515eb33d51a3d4ec0b154fa7353dc54dc675631587518f","sha256:4dc0628d453f4a3ee6a97e1794132a350cc8a7c36bd4c3a7533ba3c876f7b52c"],"state_sha256":"fa1e5a9768c9e0704c65cba1f111d3ca9457fdf43f5c3f42a22137ff2bbfe029"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"n1g4kRRhmWqS8pN9Q/zuFGJ5s1CnupqlbppU3ZmN4j0VjNhAW8MHE14vKrBzKRiEX3QsU1GAkBy5jqE/UebkCA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-24T12:21:29.057665Z","bundle_sha256":"075d0e40378016ff912833378b8fc7877d8bed984078a46af0e30d0c88ce1f3d"}}