{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2026:D5OVSTBNZRKT3QYA6Z5CWXPH6C","short_pith_number":"pith:D5OVSTBN","canonical_record":{"source":{"id":"2606.04020","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2026-06-01T09:21:24Z","cross_cats_sorted":["cs.LG"],"title_canon_sha256":"6e0aedfad5b3242aedfaa388c278ce58187ef8aa7d58a2f8a30dd30053529db6","abstract_canon_sha256":"bb08d172f66ccc5e2625d5c7aaeff82bf113d273c85cde7ef0eff575e5dc2381"},"schema_version":"1.0"},"canonical_sha256":"1f5d594c2dcc553dc300f67a2b5de7f0ad1c012d35503fb30b974c342ce9d4a0","source":{"kind":"arxiv","id":"2606.04020","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2606.04020","created_at":"2026-06-04T00:06:44Z"},{"alias_kind":"arxiv_version","alias_value":"2606.04020v1","created_at":"2026-06-04T00:06:44Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2606.04020","created_at":"2026-06-04T00:06:44Z"},{"alias_kind":"pith_short_12","alias_value":"D5OVSTBNZRKT","created_at":"2026-06-04T00:06:44Z"},{"alias_kind":"pith_short_16","alias_value":"D5OVSTBNZRKT3QYA","created_at":"2026-06-04T00:06:44Z"},{"alias_kind":"pith_short_8","alias_value":"D5OVSTBN","created_at":"2026-06-04T00:06:44Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2026:D5OVSTBNZRKT3QYA6Z5CWXPH6C","target":"record","payload":{"canonical_record":{"source":{"id":"2606.04020","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2026-06-01T09:21:24Z","cross_cats_sorted":["cs.LG"],"title_canon_sha256":"6e0aedfad5b3242aedfaa388c278ce58187ef8aa7d58a2f8a30dd30053529db6","abstract_canon_sha256":"bb08d172f66ccc5e2625d5c7aaeff82bf113d273c85cde7ef0eff575e5dc2381"},"schema_version":"1.0"},"canonical_sha256":"1f5d594c2dcc553dc300f67a2b5de7f0ad1c012d35503fb30b974c342ce9d4a0","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-06-04T00:06:44.637533Z","signature_b64":"xExym3LelmNT5ZJJU/fdoOm7ZRIv5ImGY5Pu1cAwMUDRrk53Y+lweWL6q3vYD3yFTvoX+0oq+sfdMfjlLJp4Cg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"1f5d594c2dcc553dc300f67a2b5de7f0ad1c012d35503fb30b974c342ce9d4a0","last_reissued_at":"2026-06-04T00:06:44.637181Z","signature_status":"signed_v1","first_computed_at":"2026-06-04T00:06:44.637181Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2606.04020","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-06-04T00:06:44Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"ZnpiCw5XeyLZRIcvQ9nNnkmId6vGBBZzFDiy7qSS3nFYIm0AMXGpmXFHFpTZ+uvzIRZTAk3gFRXFOBrbsrHMAQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-11T05:26:54.302204Z"},"content_sha256":"9c5b0f72cb2dd8c3b3d3cd195b3c7e249f716d92235d2701553fa381b2de5f06","schema_version":"1.0","event_id":"sha256:9c5b0f72cb2dd8c3b3d3cd195b3c7e249f716d92235d2701553fa381b2de5f06"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2026:D5OVSTBNZRKT3QYA6Z5CWXPH6C","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"SpliceBind: Isoform-Aware Prediction of Binding Pocket Druggability","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["cs.LG"],"primary_cat":"q-bio.QM","authors_text":"Austin Jin, Bryan Cheng, Joshua Chang","submitted_at":"2026-06-01T09:21:24Z","abstract_excerpt":"Splice-mediated drug resistance occurs in up to 40% of patients on targeted kinase inhibitors, yet state-of-the-art druggability tools operate on single structures and cannot compare across isoforms. We introduce SpliceBind, a graph neural network framework for isoform-aware druggability prediction. Beyond improving prediction accuracy (AUROC 0.703 vs. P2Rank 0.634, p = 0.026), we address a more fundamental question: when do structural methods succeed, and when must they fail? Systematic analysis of six clinically validated variants spanning five mechanism classes reveals a two-tier resistance"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2606.04020","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2606.04020/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-06-04T00:06:44Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"FDBEdRc1mt2pEe+8EXY+NJssquqbI4mZnQgzKhGuwe+VXFUniG4cgHPT0vFmaXrPrcq6QQL0hqjraZaUMxiVDA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-11T05:26:54.302924Z"},"content_sha256":"394301a05b684cb37e16be0d2e1ad011e5495078b2149e51dee5a11f16e70b56","schema_version":"1.0","event_id":"sha256:394301a05b684cb37e16be0d2e1ad011e5495078b2149e51dee5a11f16e70b56"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/D5OVSTBNZRKT3QYA6Z5CWXPH6C/bundle.json","state_url":"https://pith.science/pith/D5OVSTBNZRKT3QYA6Z5CWXPH6C/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/D5OVSTBNZRKT3QYA6Z5CWXPH6C/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-11T05:26:54Z","links":{"resolver":"https://pith.science/pith/D5OVSTBNZRKT3QYA6Z5CWXPH6C","bundle":"https://pith.science/pith/D5OVSTBNZRKT3QYA6Z5CWXPH6C/bundle.json","state":"https://pith.science/pith/D5OVSTBNZRKT3QYA6Z5CWXPH6C/state.json","well_known_bundle":"https://pith.science/.well-known/pith/D5OVSTBNZRKT3QYA6Z5CWXPH6C/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2026:D5OVSTBNZRKT3QYA6Z5CWXPH6C","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"bb08d172f66ccc5e2625d5c7aaeff82bf113d273c85cde7ef0eff575e5dc2381","cross_cats_sorted":["cs.LG"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2026-06-01T09:21:24Z","title_canon_sha256":"6e0aedfad5b3242aedfaa388c278ce58187ef8aa7d58a2f8a30dd30053529db6"},"schema_version":"1.0","source":{"id":"2606.04020","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2606.04020","created_at":"2026-06-04T00:06:44Z"},{"alias_kind":"arxiv_version","alias_value":"2606.04020v1","created_at":"2026-06-04T00:06:44Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2606.04020","created_at":"2026-06-04T00:06:44Z"},{"alias_kind":"pith_short_12","alias_value":"D5OVSTBNZRKT","created_at":"2026-06-04T00:06:44Z"},{"alias_kind":"pith_short_16","alias_value":"D5OVSTBNZRKT3QYA","created_at":"2026-06-04T00:06:44Z"},{"alias_kind":"pith_short_8","alias_value":"D5OVSTBN","created_at":"2026-06-04T00:06:44Z"}],"graph_snapshots":[{"event_id":"sha256:394301a05b684cb37e16be0d2e1ad011e5495078b2149e51dee5a11f16e70b56","target":"graph","created_at":"2026-06-04T00:06:44Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2606.04020/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Splice-mediated drug resistance occurs in up to 40% of patients on targeted kinase inhibitors, yet state-of-the-art druggability tools operate on single structures and cannot compare across isoforms. We introduce SpliceBind, a graph neural network framework for isoform-aware druggability prediction. Beyond improving prediction accuracy (AUROC 0.703 vs. P2Rank 0.634, p = 0.026), we address a more fundamental question: when do structural methods succeed, and when must they fail? Systematic analysis of six clinically validated variants spanning five mechanism classes reveals a two-tier resistance","authors_text":"Austin Jin, Bryan Cheng, Joshua Chang","cross_cats":["cs.LG"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2026-06-01T09:21:24Z","title":"SpliceBind: Isoform-Aware Prediction of Binding Pocket Druggability"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2606.04020","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:9c5b0f72cb2dd8c3b3d3cd195b3c7e249f716d92235d2701553fa381b2de5f06","target":"record","created_at":"2026-06-04T00:06:44Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"bb08d172f66ccc5e2625d5c7aaeff82bf113d273c85cde7ef0eff575e5dc2381","cross_cats_sorted":["cs.LG"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2026-06-01T09:21:24Z","title_canon_sha256":"6e0aedfad5b3242aedfaa388c278ce58187ef8aa7d58a2f8a30dd30053529db6"},"schema_version":"1.0","source":{"id":"2606.04020","kind":"arxiv","version":1}},"canonical_sha256":"1f5d594c2dcc553dc300f67a2b5de7f0ad1c012d35503fb30b974c342ce9d4a0","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"1f5d594c2dcc553dc300f67a2b5de7f0ad1c012d35503fb30b974c342ce9d4a0","first_computed_at":"2026-06-04T00:06:44.637181Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-06-04T00:06:44.637181Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"xExym3LelmNT5ZJJU/fdoOm7ZRIv5ImGY5Pu1cAwMUDRrk53Y+lweWL6q3vYD3yFTvoX+0oq+sfdMfjlLJp4Cg==","signature_status":"signed_v1","signed_at":"2026-06-04T00:06:44.637533Z","signed_message":"canonical_sha256_bytes"},"source_id":"2606.04020","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:9c5b0f72cb2dd8c3b3d3cd195b3c7e249f716d92235d2701553fa381b2de5f06","sha256:394301a05b684cb37e16be0d2e1ad011e5495078b2149e51dee5a11f16e70b56"],"state_sha256":"c19805f00297d3116b29f0779f082da739add30c68e9cd42910b6f9c5d6a4f1a"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"45k4xfAv4dsFDcwYmUuE7zDnvd9sxDauRlYqkQa7buQyTQc9LefyQPNSUzBJlXMhoUBJ1b4qezthVMzvo+roAg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-11T05:26:54.307182Z","bundle_sha256":"83279697a3296821ebde7a32c5d8d87b90bad20cdde19ddc8392c98853a91551"}}