{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2024:DC2HG5AH26XUABCKOZXILU5S3T","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"869213e9ed93d0aa84e561768b1eae05f0f17e1ef4f1701edd94960f11f4fdb7","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.BM","submitted_at":"2024-07-17T03:36:33Z","title_canon_sha256":"555ed5dc484382a34a8c68c091c2f6eb9f41bd51a3eabeb6b175b653b8b5cc81"},"schema_version":"1.0","source":{"id":"2407.12296","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2407.12296","created_at":"2026-07-05T10:22:02Z"},{"alias_kind":"arxiv_version","alias_value":"2407.12296v2","created_at":"2026-07-05T10:22:02Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2407.12296","created_at":"2026-07-05T10:22:02Z"},{"alias_kind":"pith_short_12","alias_value":"DC2HG5AH26XU","created_at":"2026-07-05T10:22:02Z"},{"alias_kind":"pith_short_16","alias_value":"DC2HG5AH26XUABCK","created_at":"2026-07-05T10:22:02Z"},{"alias_kind":"pith_short_8","alias_value":"DC2HG5AH","created_at":"2026-07-05T10:22:02Z"}],"graph_snapshots":[{"event_id":"sha256:bd54fe305b45aecac646206a1093bdc87f27c9f7df195c61deebedab6e8072d3","target":"graph","created_at":"2026-07-05T10:22:02Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2407.12296/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Large language models (LLMs) have shown remarkable advancements in chemistry and biomedical research, acting as versatile foundation models for various tasks. We introduce AMP-Designer, an LLM-based approach for swiftly designing novel antimicrobial peptides (AMPs) with desired properties. Within 11 days, AMP-Designer achieved the de novo design of 18 AMPs with broad-spectrum activity against Gram-negative bacteria. In vitro validation revealed a 94.4% success rate, with two candidates demonstrating exceptional antibacterial efficacy, minimal hemotoxicity, stability in human plasma, and low po","authors_text":"Chang-Yu Hsieh, Guangning Yan, Hui Shi, Jiameng Yu, Jianwen Feng, Jike Wang, Jingxuan Ge, Lirong Wen, Mingyang Wang, Peichen Pan, Tianyue Wang, Tingjun Hou, Xingcai Zhang, Xujun Zhang, Yafeng Deng, Yan Wang, Yu Kang, Zhenxing Wu, Zhihui Jiang","cross_cats":[],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.BM","submitted_at":"2024-07-17T03:36:33Z","title":"Discovery of novel antimicrobial peptides with notable antibacterial potency by a LLM-based foundation model"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2407.12296","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:9fb79b8cf6a241d958613fd6ad04572f3bef584a502fa06bd3083627d5d41f18","target":"record","created_at":"2026-07-05T10:22:02Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"869213e9ed93d0aa84e561768b1eae05f0f17e1ef4f1701edd94960f11f4fdb7","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.BM","submitted_at":"2024-07-17T03:36:33Z","title_canon_sha256":"555ed5dc484382a34a8c68c091c2f6eb9f41bd51a3eabeb6b175b653b8b5cc81"},"schema_version":"1.0","source":{"id":"2407.12296","kind":"arxiv","version":2}},"canonical_sha256":"18b4737407d7af40044a766e85d3b2dcfbe223c2be191c8ed971bce6270731e4","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"18b4737407d7af40044a766e85d3b2dcfbe223c2be191c8ed971bce6270731e4","first_computed_at":"2026-07-05T10:22:02.342183Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T10:22:02.342183Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"Ely6HTedcfg+VOg7JHb/uH7kP/pyBfG0f/Jc+0seCE13lPH6Uoq5VJAd2spn466PbuMYa0nwG4/EOFb7FcH3Bg==","signature_status":"signed_v1","signed_at":"2026-07-05T10:22:02.342741Z","signed_message":"canonical_sha256_bytes"},"source_id":"2407.12296","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:9fb79b8cf6a241d958613fd6ad04572f3bef584a502fa06bd3083627d5d41f18","sha256:bd54fe305b45aecac646206a1093bdc87f27c9f7df195c61deebedab6e8072d3"],"state_sha256":"26bab14cae6cfe87d320355a01f5e01ba09acb4b61c39404f5ea467c64ee7dfa"}