{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2020:DEGNRWS6B63VHFYR2HFBMXQ4HS","short_pith_number":"pith:DEGNRWS6","canonical_record":{"source":{"id":"2010.12948","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.LG","submitted_at":"2020-10-24T18:23:02Z","cross_cats_sorted":["eess.IV","q-bio.NC"],"title_canon_sha256":"fb9d72da73863549180eef191386092ff92f432cb70c1529a858f746de9e3643","abstract_canon_sha256":"7a721363b435c850891bd8b0600b9c02f43398f3c2b00e0ba29874e5c05192f5"},"schema_version":"1.0"},"canonical_sha256":"190cd8da5e0fb7539711d1ca165e1c3ca0cba1aa1642a0312f0c6a6090752d64","source":{"kind":"arxiv","id":"2010.12948","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2010.12948","created_at":"2026-07-05T01:45:50Z"},{"alias_kind":"arxiv_version","alias_value":"2010.12948v1","created_at":"2026-07-05T01:45:50Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2010.12948","created_at":"2026-07-05T01:45:50Z"},{"alias_kind":"pith_short_12","alias_value":"DEGNRWS6B63V","created_at":"2026-07-05T01:45:50Z"},{"alias_kind":"pith_short_16","alias_value":"DEGNRWS6B63VHFYR","created_at":"2026-07-05T01:45:50Z"},{"alias_kind":"pith_short_8","alias_value":"DEGNRWS6","created_at":"2026-07-05T01:45:50Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2020:DEGNRWS6B63VHFYR2HFBMXQ4HS","target":"record","payload":{"canonical_record":{"source":{"id":"2010.12948","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.LG","submitted_at":"2020-10-24T18:23:02Z","cross_cats_sorted":["eess.IV","q-bio.NC"],"title_canon_sha256":"fb9d72da73863549180eef191386092ff92f432cb70c1529a858f746de9e3643","abstract_canon_sha256":"7a721363b435c850891bd8b0600b9c02f43398f3c2b00e0ba29874e5c05192f5"},"schema_version":"1.0"},"canonical_sha256":"190cd8da5e0fb7539711d1ca165e1c3ca0cba1aa1642a0312f0c6a6090752d64","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T01:45:50.062049Z","signature_b64":"V8h4fWrldIaEYBXflX55IfXu2i/yyvkosDobCBcqRHoMIMYiXKF1YHeG9jR3vuDE6GbJRzV0B0hVboHL/Wb8AA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"190cd8da5e0fb7539711d1ca165e1c3ca0cba1aa1642a0312f0c6a6090752d64","last_reissued_at":"2026-07-05T01:45:50.061702Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T01:45:50.061702Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2010.12948","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T01:45:50Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"9N3qWjE/W/MbpvaWAm1vJf3vviO73KSnyi7tiuiQa18bgn1l2quhJV5wu9aYfk+BmCLgBFzt0zD1mhR10VJmCA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-21T18:44:46.413366Z"},"content_sha256":"9447462b3fc4595ad457a181de6c9251493226d7885812e31cb21421a2c5cc0f","schema_version":"1.0","event_id":"sha256:9447462b3fc4595ad457a181de6c9251493226d7885812e31cb21421a2c5cc0f"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2020:DEGNRWS6B63VHFYR2HFBMXQ4HS","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"DeepAtrophy: Teaching a Neural Network to Differentiate Progressive Changes from Noise on Longitudinal MRI in Alzheimer's Disease","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["eess.IV","q-bio.NC"],"primary_cat":"cs.LG","authors_text":"David A. Wolk, Jiancong Wang, Laura E.M. Wisse, Long Xie, Mengjin Dong, Paul Yushkevich (for the Alzheimer's Disease Neuroimaging Initiative), Robin deFlores, Sandhitsu R. Das","submitted_at":"2020-10-24T18:23:02Z","abstract_excerpt":"Volume change measures derived from longitudinal MRI (e.g. hippocampal atrophy) are a well-studied biomarker of disease progression in Alzheimer's Disease (AD) and are used in clinical trials to track the therapeutic efficacy of disease-modifying treatments. However, longitudinal MRI change measures can be confounded by non-biological factors, such as different degrees of head motion and susceptibility artifact between pairs of MRI scans. We hypothesize that deep learning methods applied directly to pairs of longitudinal MRI scans can be trained to differentiate between biological changes and "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2010.12948","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2010.12948/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T01:45:50Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"d2pbpefT1epI7PTFxTENxM5LYuR9Lb7CGrPz6oHY2VrVTEMFlF6J7Y6Lf3cdXWnZ7yZz2l63lywLueFsLGcODw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-21T18:44:46.413874Z"},"content_sha256":"847f937e05bafcb5a684d09eba849d3d991ee560b35efedec05eb73c9543ad3d","schema_version":"1.0","event_id":"sha256:847f937e05bafcb5a684d09eba849d3d991ee560b35efedec05eb73c9543ad3d"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/DEGNRWS6B63VHFYR2HFBMXQ4HS/bundle.json","state_url":"https://pith.science/pith/DEGNRWS6B63VHFYR2HFBMXQ4HS/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/DEGNRWS6B63VHFYR2HFBMXQ4HS/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-21T18:44:46Z","links":{"resolver":"https://pith.science/pith/DEGNRWS6B63VHFYR2HFBMXQ4HS","bundle":"https://pith.science/pith/DEGNRWS6B63VHFYR2HFBMXQ4HS/bundle.json","state":"https://pith.science/pith/DEGNRWS6B63VHFYR2HFBMXQ4HS/state.json","well_known_bundle":"https://pith.science/.well-known/pith/DEGNRWS6B63VHFYR2HFBMXQ4HS/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2020:DEGNRWS6B63VHFYR2HFBMXQ4HS","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"7a721363b435c850891bd8b0600b9c02f43398f3c2b00e0ba29874e5c05192f5","cross_cats_sorted":["eess.IV","q-bio.NC"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.LG","submitted_at":"2020-10-24T18:23:02Z","title_canon_sha256":"fb9d72da73863549180eef191386092ff92f432cb70c1529a858f746de9e3643"},"schema_version":"1.0","source":{"id":"2010.12948","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2010.12948","created_at":"2026-07-05T01:45:50Z"},{"alias_kind":"arxiv_version","alias_value":"2010.12948v1","created_at":"2026-07-05T01:45:50Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2010.12948","created_at":"2026-07-05T01:45:50Z"},{"alias_kind":"pith_short_12","alias_value":"DEGNRWS6B63V","created_at":"2026-07-05T01:45:50Z"},{"alias_kind":"pith_short_16","alias_value":"DEGNRWS6B63VHFYR","created_at":"2026-07-05T01:45:50Z"},{"alias_kind":"pith_short_8","alias_value":"DEGNRWS6","created_at":"2026-07-05T01:45:50Z"}],"graph_snapshots":[{"event_id":"sha256:847f937e05bafcb5a684d09eba849d3d991ee560b35efedec05eb73c9543ad3d","target":"graph","created_at":"2026-07-05T01:45:50Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2010.12948/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Volume change measures derived from longitudinal MRI (e.g. hippocampal atrophy) are a well-studied biomarker of disease progression in Alzheimer's Disease (AD) and are used in clinical trials to track the therapeutic efficacy of disease-modifying treatments. However, longitudinal MRI change measures can be confounded by non-biological factors, such as different degrees of head motion and susceptibility artifact between pairs of MRI scans. We hypothesize that deep learning methods applied directly to pairs of longitudinal MRI scans can be trained to differentiate between biological changes and ","authors_text":"David A. Wolk, Jiancong Wang, Laura E.M. Wisse, Long Xie, Mengjin Dong, Paul Yushkevich (for the Alzheimer's Disease Neuroimaging Initiative), Robin deFlores, Sandhitsu R. Das","cross_cats":["eess.IV","q-bio.NC"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.LG","submitted_at":"2020-10-24T18:23:02Z","title":"DeepAtrophy: Teaching a Neural Network to Differentiate Progressive Changes from Noise on Longitudinal MRI in Alzheimer's Disease"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2010.12948","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:9447462b3fc4595ad457a181de6c9251493226d7885812e31cb21421a2c5cc0f","target":"record","created_at":"2026-07-05T01:45:50Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"7a721363b435c850891bd8b0600b9c02f43398f3c2b00e0ba29874e5c05192f5","cross_cats_sorted":["eess.IV","q-bio.NC"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.LG","submitted_at":"2020-10-24T18:23:02Z","title_canon_sha256":"fb9d72da73863549180eef191386092ff92f432cb70c1529a858f746de9e3643"},"schema_version":"1.0","source":{"id":"2010.12948","kind":"arxiv","version":1}},"canonical_sha256":"190cd8da5e0fb7539711d1ca165e1c3ca0cba1aa1642a0312f0c6a6090752d64","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"190cd8da5e0fb7539711d1ca165e1c3ca0cba1aa1642a0312f0c6a6090752d64","first_computed_at":"2026-07-05T01:45:50.061702Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T01:45:50.061702Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"V8h4fWrldIaEYBXflX55IfXu2i/yyvkosDobCBcqRHoMIMYiXKF1YHeG9jR3vuDE6GbJRzV0B0hVboHL/Wb8AA==","signature_status":"signed_v1","signed_at":"2026-07-05T01:45:50.062049Z","signed_message":"canonical_sha256_bytes"},"source_id":"2010.12948","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:9447462b3fc4595ad457a181de6c9251493226d7885812e31cb21421a2c5cc0f","sha256:847f937e05bafcb5a684d09eba849d3d991ee560b35efedec05eb73c9543ad3d"],"state_sha256":"a7d69b88f2d1106bf56dc397479cb32a05d8ea08d23ea607fd5b2f0a71778c59"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"wWbBrmkeSPnE1hZAqDoWiUxuDRvXeyT7iDrB8uJZcavDLIwFmcvt2Eqdrw/Gz85HYiPk5xrcOh3D5+CnZQTtCw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-21T18:44:46.417318Z","bundle_sha256":"a3283093a507b05eab9022317e9f3b08eda94eedc00690c64c16f2a6945c3468"}}