{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2026:DNHFITTUKI6AK7A2QYNMTTD5LQ","short_pith_number":"pith:DNHFITTU","canonical_record":{"source":{"id":"2608.06321","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2026-08-06T17:36:20Z","cross_cats_sorted":[],"title_canon_sha256":"f1708f6c47824dc5e5cd8100720067d01c02b4c605f15b4306226a2e562ff33f","abstract_canon_sha256":"342804f27c21ce5ed4dffd83d8587cedca3fba254a3309f18e7f48a1f4fc0dfe"},"schema_version":"1.0"},"canonical_sha256":"1b4e544e74523c057c1a861ac9cc7d5c266cee72e3fe177cc88f88f4b4518fa9","source":{"kind":"arxiv","id":"2608.06321","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2608.06321","created_at":"2026-08-07T01:41:21Z"},{"alias_kind":"arxiv_version","alias_value":"2608.06321v1","created_at":"2026-08-07T01:41:21Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2608.06321","created_at":"2026-08-07T01:41:21Z"},{"alias_kind":"pith_short_12","alias_value":"DNHFITTUKI6A","created_at":"2026-08-07T01:41:21Z"},{"alias_kind":"pith_short_16","alias_value":"DNHFITTUKI6AK7A2","created_at":"2026-08-07T01:41:21Z"},{"alias_kind":"pith_short_8","alias_value":"DNHFITTU","created_at":"2026-08-07T01:41:21Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2026:DNHFITTUKI6AK7A2QYNMTTD5LQ","target":"record","payload":{"canonical_record":{"source":{"id":"2608.06321","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2026-08-06T17:36:20Z","cross_cats_sorted":[],"title_canon_sha256":"f1708f6c47824dc5e5cd8100720067d01c02b4c605f15b4306226a2e562ff33f","abstract_canon_sha256":"342804f27c21ce5ed4dffd83d8587cedca3fba254a3309f18e7f48a1f4fc0dfe"},"schema_version":"1.0"},"canonical_sha256":"1b4e544e74523c057c1a861ac9cc7d5c266cee72e3fe177cc88f88f4b4518fa9","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-08-07T01:41:21.961528Z","signature_b64":"PzUdFPkqwdFST3oBFWr5UPgFKns0jEOwk4ZxklpWpeM2rtNNxamV5A6BfliWqAVzSFrUFMPT6K7bSCTh/2POBA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"1b4e544e74523c057c1a861ac9cc7d5c266cee72e3fe177cc88f88f4b4518fa9","last_reissued_at":"2026-08-07T01:41:21.959649Z","signature_status":"signed_v1","first_computed_at":"2026-08-07T01:41:21.959649Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2608.06321","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-08-07T01:41:21Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"+sPRXmZecXh5D6fzGfRXvkRMRUoH8gkOFgIHFgm4UEFiCtGNWhc35DQFBHEmff91PItCfaK1byOYKBjM/1zPBQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-13T23:22:54.757267Z"},"content_sha256":"a7e47c61d3ca373394db2d4b292c32006602594829b41d8cf14f50b4fc32d14b","schema_version":"1.0","event_id":"sha256:a7e47c61d3ca373394db2d4b292c32006602594829b41d8cf14f50b4fc32d14b"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2026:DNHFITTUKI6AK7A2QYNMTTD5LQ","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"An open-source framework for predicting ultrasound neuromodulation: bridging tissue elastomechanics and neuron firing dynamics","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"physics.med-ph","authors_text":"Gianmarco Pinton","submitted_at":"2026-08-06T17:36:20Z","abstract_excerpt":"Transcranial focused ultrasound is a non-invasive neuromodulation modality with millimetre-scale resolution, but its biophysical mechanism of action remains unresolved. Exposure is conventionally specified by transducer surface or derated focal pressure, quantities only indirectly related to what matters for therapy: which neurons fire and through which pathway. We address this gap with an end-to-end computational framework that maps a transcranial acoustic field to per-voxel neural firing maps registered to anatomy. The pipeline couples heterogeneous nonlinear full-wave acoustic propagation, "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2608.06321","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2608.06321/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-08-07T01:41:21Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"B78SoocIYODptARr7izvbsaL9ZNqfqF3ncui/va709tGvE4lEnc1IbiTq7VjClUt4cAuwruaiarTL6RW+WvzDg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-13T23:22:54.757669Z"},"content_sha256":"4de121640419d8d5bb33cb2a7ecb44f96d3c27a35fd74e0fb4c82ee4ffb2d915","schema_version":"1.0","event_id":"sha256:4de121640419d8d5bb33cb2a7ecb44f96d3c27a35fd74e0fb4c82ee4ffb2d915"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/DNHFITTUKI6AK7A2QYNMTTD5LQ/bundle.json","state_url":"https://pith.science/pith/DNHFITTUKI6AK7A2QYNMTTD5LQ/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/DNHFITTUKI6AK7A2QYNMTTD5LQ/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-13T23:22:54Z","links":{"resolver":"https://pith.science/pith/DNHFITTUKI6AK7A2QYNMTTD5LQ","bundle":"https://pith.science/pith/DNHFITTUKI6AK7A2QYNMTTD5LQ/bundle.json","state":"https://pith.science/pith/DNHFITTUKI6AK7A2QYNMTTD5LQ/state.json","well_known_bundle":"https://pith.science/.well-known/pith/DNHFITTUKI6AK7A2QYNMTTD5LQ/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2026:DNHFITTUKI6AK7A2QYNMTTD5LQ","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"342804f27c21ce5ed4dffd83d8587cedca3fba254a3309f18e7f48a1f4fc0dfe","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2026-08-06T17:36:20Z","title_canon_sha256":"f1708f6c47824dc5e5cd8100720067d01c02b4c605f15b4306226a2e562ff33f"},"schema_version":"1.0","source":{"id":"2608.06321","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2608.06321","created_at":"2026-08-07T01:41:21Z"},{"alias_kind":"arxiv_version","alias_value":"2608.06321v1","created_at":"2026-08-07T01:41:21Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2608.06321","created_at":"2026-08-07T01:41:21Z"},{"alias_kind":"pith_short_12","alias_value":"DNHFITTUKI6A","created_at":"2026-08-07T01:41:21Z"},{"alias_kind":"pith_short_16","alias_value":"DNHFITTUKI6AK7A2","created_at":"2026-08-07T01:41:21Z"},{"alias_kind":"pith_short_8","alias_value":"DNHFITTU","created_at":"2026-08-07T01:41:21Z"}],"graph_snapshots":[{"event_id":"sha256:4de121640419d8d5bb33cb2a7ecb44f96d3c27a35fd74e0fb4c82ee4ffb2d915","target":"graph","created_at":"2026-08-07T01:41:21Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2608.06321/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Transcranial focused ultrasound is a non-invasive neuromodulation modality with millimetre-scale resolution, but its biophysical mechanism of action remains unresolved. Exposure is conventionally specified by transducer surface or derated focal pressure, quantities only indirectly related to what matters for therapy: which neurons fire and through which pathway. We address this gap with an end-to-end computational framework that maps a transcranial acoustic field to per-voxel neural firing maps registered to anatomy. The pipeline couples heterogeneous nonlinear full-wave acoustic propagation, ","authors_text":"Gianmarco Pinton","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2026-08-06T17:36:20Z","title":"An open-source framework for predicting ultrasound neuromodulation: bridging tissue elastomechanics and neuron firing dynamics"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2608.06321","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:a7e47c61d3ca373394db2d4b292c32006602594829b41d8cf14f50b4fc32d14b","target":"record","created_at":"2026-08-07T01:41:21Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"342804f27c21ce5ed4dffd83d8587cedca3fba254a3309f18e7f48a1f4fc0dfe","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.med-ph","submitted_at":"2026-08-06T17:36:20Z","title_canon_sha256":"f1708f6c47824dc5e5cd8100720067d01c02b4c605f15b4306226a2e562ff33f"},"schema_version":"1.0","source":{"id":"2608.06321","kind":"arxiv","version":1}},"canonical_sha256":"1b4e544e74523c057c1a861ac9cc7d5c266cee72e3fe177cc88f88f4b4518fa9","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"1b4e544e74523c057c1a861ac9cc7d5c266cee72e3fe177cc88f88f4b4518fa9","first_computed_at":"2026-08-07T01:41:21.959649Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-08-07T01:41:21.959649Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"PzUdFPkqwdFST3oBFWr5UPgFKns0jEOwk4ZxklpWpeM2rtNNxamV5A6BfliWqAVzSFrUFMPT6K7bSCTh/2POBA==","signature_status":"signed_v1","signed_at":"2026-08-07T01:41:21.961528Z","signed_message":"canonical_sha256_bytes"},"source_id":"2608.06321","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:a7e47c61d3ca373394db2d4b292c32006602594829b41d8cf14f50b4fc32d14b","sha256:4de121640419d8d5bb33cb2a7ecb44f96d3c27a35fd74e0fb4c82ee4ffb2d915"],"state_sha256":"67b261f10052d1d11ceaf41e19244c7a3d11f30ce56ea4eb08c918f1f0decbc8"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"M+nMXzU9X7oDmUjEmkrT+DKhjsbwsxWzZlhOL1YGR0lpeF31/tLuvsPhyza3p5YLeKoQOOSPxgQZyIDSwwEeAA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-13T23:22:54.774919Z","bundle_sha256":"6d021965f329053f3f337a230522a141df7d14edc32b27233cb581b81bd41460"}}