{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2021:DNONAE2QVL27FXIVRMXE5HEJ7J","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"fc53cf3dc1776310398f3b74018f7e995ee24e75e835a56816655439dd758068","cross_cats_sorted":["q-bio.GN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2021-10-30T16:37:04Z","title_canon_sha256":"ca2a50e07406322b5ffc69351798e57a45e485e7c9f723da8fddbf65ec0e2945"},"schema_version":"1.0","source":{"id":"2111.00287","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2111.00287","created_at":"2026-07-05T03:27:40Z"},{"alias_kind":"arxiv_version","alias_value":"2111.00287v1","created_at":"2026-07-05T03:27:40Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2111.00287","created_at":"2026-07-05T03:27:40Z"},{"alias_kind":"pith_short_12","alias_value":"DNONAE2QVL27","created_at":"2026-07-05T03:27:40Z"},{"alias_kind":"pith_short_16","alias_value":"DNONAE2QVL27FXIV","created_at":"2026-07-05T03:27:40Z"},{"alias_kind":"pith_short_8","alias_value":"DNONAE2Q","created_at":"2026-07-05T03:27:40Z"}],"graph_snapshots":[{"event_id":"sha256:48fa63f65690ed4da167b8935b528a42f99203026a53174793441448efc3f89a","target":"graph","created_at":"2026-07-05T03:27:40Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2111.00287/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Background:Gene regulations often change over time rather than being constant. But many of gene regulatory networks extracted from databases are static. The tumor suppressor gene $P53$ is involved in the pathogenesis of many tumors, and its inhibition effects occur after a certain period. Therefore, it is of great significance to elucidate the regulation mechanism over time points. Result:A qualitative method for representing dynamic gene regulatory network is developed, called CdtGRN. It adopts the combination of convolutional neural networks(CNN) and fully connected networks(DNN) as the core","authors_text":"Lin Zhang, Ruijie Xu, Yu Chen","cross_cats":["q-bio.GN"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2021-10-30T16:37:04Z","title":"CdtGRN: Construction of qualitative time-delayed gene regulatory networks with a deep learning method"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2111.00287","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:e99982fd6b8946481c1aeeebe4474528689084b3cfd7c4b44034df7c5f30df98","target":"record","created_at":"2026-07-05T03:27:40Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"fc53cf3dc1776310398f3b74018f7e995ee24e75e835a56816655439dd758068","cross_cats_sorted":["q-bio.GN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2021-10-30T16:37:04Z","title_canon_sha256":"ca2a50e07406322b5ffc69351798e57a45e485e7c9f723da8fddbf65ec0e2945"},"schema_version":"1.0","source":{"id":"2111.00287","kind":"arxiv","version":1}},"canonical_sha256":"1b5cd01350aaf5f2dd158b2e4e9c89fa4c4eacf14b710ec469a4a60467454f1c","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"1b5cd01350aaf5f2dd158b2e4e9c89fa4c4eacf14b710ec469a4a60467454f1c","first_computed_at":"2026-07-05T03:27:40.753411Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T03:27:40.753411Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"J47sVfK3VFZKUWNYb1j8suK3W5Y2l7gSjy1/ZFjA41poaMOzbxHHBAmRqDNY4NCGjkxtf9r+3PFPDEm2LFZxBQ==","signature_status":"signed_v1","signed_at":"2026-07-05T03:27:40.753966Z","signed_message":"canonical_sha256_bytes"},"source_id":"2111.00287","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:e99982fd6b8946481c1aeeebe4474528689084b3cfd7c4b44034df7c5f30df98","sha256:48fa63f65690ed4da167b8935b528a42f99203026a53174793441448efc3f89a"],"state_sha256":"b4381557f6595e364ee7b9455c065eff9927ddc21cc89155de6a1e33894984bf"}