{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2026:DO4DNXOW5NUROIKNM325J37EYQ","short_pith_number":"pith:DO4DNXOW","schema_version":"1.0","canonical_sha256":"1bb836ddd6eb6917214d66f5d4efe4c40c8c211a5b382ab41256d42ae425f91c","source":{"kind":"arxiv","id":"2606.22318","version":1},"attestation_state":"computed","paper":{"title":"PROMPT: A Pre-registered Randomized Protocol for Component-Level Evaluation of Clinical AI Prompts","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.OT","authors_text":"Avneek Sandhu, Bin Hu, Shahryar Wasif","submitted_at":"2026-06-21T03:20:15Z","abstract_excerpt":"BACKGROUND:Prompt engineering shapes medical AI outcomes, but prompt components are rarely tested as clinical interventions. We developed PROMPT (Pre-registered Randomized Outcome Measurement for Prompt Testing), a protocol using pre-specification, randomization, matched controls, dismantling, and decision rules.METHODS:Two pre-registered demonstrations used Claude Sonnet 4.6. Exp 1 used a synthetic tumbling-E orientation task: 630-trial main study, 480-trial dismantling study, and 1,050-trial 2x2 factorial extension. Exp 2 used the same arms on 16 label-masked CBIS-DDSM mammographic crops in "},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"2606.22318","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.OT","submitted_at":"2026-06-21T03:20:15Z","cross_cats_sorted":[],"title_canon_sha256":"30ba91c324e9edba06ce96546c2f232232fea0904487d4eff5ff2c64c8782af2","abstract_canon_sha256":"0caf984fff4263e3b7ee9f5b573caba02c169865889282f9e79dac967691ae73"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-06-23T02:13:34.767456Z","signature_b64":"3EP8pJ45e/u44FCVTnJWwqyBlgOSqCnpO7kslOjfNSUm0GDXbZ9ZDQmFdfG/Zc/S81+tTV+JnapAzM3pW85ZBg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"1bb836ddd6eb6917214d66f5d4efe4c40c8c211a5b382ab41256d42ae425f91c","last_reissued_at":"2026-06-23T02:13:34.767046Z","signature_status":"signed_v1","first_computed_at":"2026-06-23T02:13:34.767046Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"PROMPT: A Pre-registered Randomized Protocol for Component-Level Evaluation of Clinical AI Prompts","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.OT","authors_text":"Avneek Sandhu, Bin Hu, Shahryar Wasif","submitted_at":"2026-06-21T03:20:15Z","abstract_excerpt":"BACKGROUND:Prompt engineering shapes medical AI outcomes, but prompt components are rarely tested as clinical interventions. We developed PROMPT (Pre-registered Randomized Outcome Measurement for Prompt Testing), a protocol using pre-specification, randomization, matched controls, dismantling, and decision rules.METHODS:Two pre-registered demonstrations used Claude Sonnet 4.6. Exp 1 used a synthetic tumbling-E orientation task: 630-trial main study, 480-trial dismantling study, and 1,050-trial 2x2 factorial extension. Exp 2 used the same arms on 16 label-masked CBIS-DDSM mammographic crops in "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2606.22318","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2606.22318/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"2606.22318","created_at":"2026-06-23T02:13:34.767106+00:00"},{"alias_kind":"arxiv_version","alias_value":"2606.22318v1","created_at":"2026-06-23T02:13:34.767106+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2606.22318","created_at":"2026-06-23T02:13:34.767106+00:00"},{"alias_kind":"pith_short_12","alias_value":"DO4DNXOW5NUR","created_at":"2026-06-23T02:13:34.767106+00:00"},{"alias_kind":"pith_short_16","alias_value":"DO4DNXOW5NUROIKN","created_at":"2026-06-23T02:13:34.767106+00:00"},{"alias_kind":"pith_short_8","alias_value":"DO4DNXOW","created_at":"2026-06-23T02:13:34.767106+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/DO4DNXOW5NUROIKNM325J37EYQ","json":"https://pith.science/pith/DO4DNXOW5NUROIKNM325J37EYQ.json","graph_json":"https://pith.science/api/pith-number/DO4DNXOW5NUROIKNM325J37EYQ/graph.json","events_json":"https://pith.science/api/pith-number/DO4DNXOW5NUROIKNM325J37EYQ/events.json","paper":"https://pith.science/paper/DO4DNXOW"},"agent_actions":{"view_html":"https://pith.science/pith/DO4DNXOW5NUROIKNM325J37EYQ","download_json":"https://pith.science/pith/DO4DNXOW5NUROIKNM325J37EYQ.json","view_paper":"https://pith.science/paper/DO4DNXOW","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=2606.22318&json=true","fetch_graph":"https://pith.science/api/pith-number/DO4DNXOW5NUROIKNM325J37EYQ/graph.json","fetch_events":"https://pith.science/api/pith-number/DO4DNXOW5NUROIKNM325J37EYQ/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/DO4DNXOW5NUROIKNM325J37EYQ/action/timestamp_anchor","attest_storage":"https://pith.science/pith/DO4DNXOW5NUROIKNM325J37EYQ/action/storage_attestation","attest_author":"https://pith.science/pith/DO4DNXOW5NUROIKNM325J37EYQ/action/author_attestation","sign_citation":"https://pith.science/pith/DO4DNXOW5NUROIKNM325J37EYQ/action/citation_signature","submit_replication":"https://pith.science/pith/DO4DNXOW5NUROIKNM325J37EYQ/action/replication_record"}},"created_at":"2026-06-23T02:13:34.767106+00:00","updated_at":"2026-06-23T02:13:34.767106+00:00"}