{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2015:DTBL4W2PTFNMOJWIXWHU7UFGP5","short_pith_number":"pith:DTBL4W2P","canonical_record":{"source":{"id":"1505.07526","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.SC","submitted_at":"2015-05-28T01:42:34Z","cross_cats_sorted":["cond-mat.stat-mech","stat.AP"],"title_canon_sha256":"518e0fb6dc7a0474608794f285cd372b13084121cf25183b803b8804b5afbbfa","abstract_canon_sha256":"721add7310b6f516efb858f682f0c4beaf9b86a4703d0dc4c6498176c1cb717f"},"schema_version":"1.0"},"canonical_sha256":"1cc2be5b4f995ac726c8bd8f4fd0a67f596200c7654b264732a3735d879cbd7e","source":{"kind":"arxiv","id":"1505.07526","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1505.07526","created_at":"2026-05-18T01:23:18Z"},{"alias_kind":"arxiv_version","alias_value":"1505.07526v1","created_at":"2026-05-18T01:23:18Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1505.07526","created_at":"2026-05-18T01:23:18Z"},{"alias_kind":"pith_short_12","alias_value":"DTBL4W2PTFNM","created_at":"2026-05-18T12:29:17Z"},{"alias_kind":"pith_short_16","alias_value":"DTBL4W2PTFNMOJWI","created_at":"2026-05-18T12:29:17Z"},{"alias_kind":"pith_short_8","alias_value":"DTBL4W2P","created_at":"2026-05-18T12:29:17Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2015:DTBL4W2PTFNMOJWIXWHU7UFGP5","target":"record","payload":{"canonical_record":{"source":{"id":"1505.07526","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.SC","submitted_at":"2015-05-28T01:42:34Z","cross_cats_sorted":["cond-mat.stat-mech","stat.AP"],"title_canon_sha256":"518e0fb6dc7a0474608794f285cd372b13084121cf25183b803b8804b5afbbfa","abstract_canon_sha256":"721add7310b6f516efb858f682f0c4beaf9b86a4703d0dc4c6498176c1cb717f"},"schema_version":"1.0"},"canonical_sha256":"1cc2be5b4f995ac726c8bd8f4fd0a67f596200c7654b264732a3735d879cbd7e","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:23:18.818510Z","signature_b64":"luIsBspLHouYeuMjQnC8OfOo19k1VrKWtx1zHnwxVtVJcOcHc+575v0riub6cZ6gLGtZEVeYzyeVRtJf54HbAw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"1cc2be5b4f995ac726c8bd8f4fd0a67f596200c7654b264732a3735d879cbd7e","last_reissued_at":"2026-05-18T01:23:18.818038Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:23:18.818038Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1505.07526","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:23:18Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"EaxKHaZ4GMkJ64IRQt7hUn5kvGf89Cj3mqIOtjc2EQtTC72SsUkuFosFxg1qfX7W9gA8mj2rZa30JUiDthQcCw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-28T11:31:45.822695Z"},"content_sha256":"518079d36ef7c00ad7c25d74aa6508595cd75214b6c04a8d3eedbcc3ba80ba55","schema_version":"1.0","event_id":"sha256:518079d36ef7c00ad7c25d74aa6508595cd75214b6c04a8d3eedbcc3ba80ba55"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2015:DTBL4W2PTFNMOJWIXWHU7UFGP5","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Energy dissipation in an adaptive molecular circuit","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cond-mat.stat-mech","stat.AP"],"primary_cat":"q-bio.SC","authors_text":"Lei-Han Tang, Shou-Wen Wang, Yueheng Lan","submitted_at":"2015-05-28T01:42:34Z","abstract_excerpt":"The ability to monitor nutrient and other environmental conditions with high sensitivity is crucial for cell growth and survival. Sensory adaptation allows a cell to recover its sensitivity after a transient response to a shift in the strength of extracellular stimulus. The working principles of adaptation have been established previously based on rate equations which do not consider fluctuations in a thermal environment. Recently, G. Lan et al. (Nature Phys., 8:422-8, 2012) performed a detailed analysis of a stochastic model for the E. coli sensory network. They showed that accurate adaptatio"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1505.07526","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:23:18Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"iE2NZZJiTkfCwm1/tu2zo6EX4THpsmLB8erZUIOq/8vZo+wN99D6FIf0o9WYc8oZzx4q3dzmLgGCQz3+hinpCg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-28T11:31:45.823042Z"},"content_sha256":"f89e1f4fc97a8d973a1d4ce370b1eda7e4f83d580c953a30a5a6701ea190403b","schema_version":"1.0","event_id":"sha256:f89e1f4fc97a8d973a1d4ce370b1eda7e4f83d580c953a30a5a6701ea190403b"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/DTBL4W2PTFNMOJWIXWHU7UFGP5/bundle.json","state_url":"https://pith.science/pith/DTBL4W2PTFNMOJWIXWHU7UFGP5/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/DTBL4W2PTFNMOJWIXWHU7UFGP5/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-28T11:31:45Z","links":{"resolver":"https://pith.science/pith/DTBL4W2PTFNMOJWIXWHU7UFGP5","bundle":"https://pith.science/pith/DTBL4W2PTFNMOJWIXWHU7UFGP5/bundle.json","state":"https://pith.science/pith/DTBL4W2PTFNMOJWIXWHU7UFGP5/state.json","well_known_bundle":"https://pith.science/.well-known/pith/DTBL4W2PTFNMOJWIXWHU7UFGP5/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2015:DTBL4W2PTFNMOJWIXWHU7UFGP5","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"721add7310b6f516efb858f682f0c4beaf9b86a4703d0dc4c6498176c1cb717f","cross_cats_sorted":["cond-mat.stat-mech","stat.AP"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.SC","submitted_at":"2015-05-28T01:42:34Z","title_canon_sha256":"518e0fb6dc7a0474608794f285cd372b13084121cf25183b803b8804b5afbbfa"},"schema_version":"1.0","source":{"id":"1505.07526","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1505.07526","created_at":"2026-05-18T01:23:18Z"},{"alias_kind":"arxiv_version","alias_value":"1505.07526v1","created_at":"2026-05-18T01:23:18Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1505.07526","created_at":"2026-05-18T01:23:18Z"},{"alias_kind":"pith_short_12","alias_value":"DTBL4W2PTFNM","created_at":"2026-05-18T12:29:17Z"},{"alias_kind":"pith_short_16","alias_value":"DTBL4W2PTFNMOJWI","created_at":"2026-05-18T12:29:17Z"},{"alias_kind":"pith_short_8","alias_value":"DTBL4W2P","created_at":"2026-05-18T12:29:17Z"}],"graph_snapshots":[{"event_id":"sha256:f89e1f4fc97a8d973a1d4ce370b1eda7e4f83d580c953a30a5a6701ea190403b","target":"graph","created_at":"2026-05-18T01:23:18Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"The ability to monitor nutrient and other environmental conditions with high sensitivity is crucial for cell growth and survival. Sensory adaptation allows a cell to recover its sensitivity after a transient response to a shift in the strength of extracellular stimulus. The working principles of adaptation have been established previously based on rate equations which do not consider fluctuations in a thermal environment. Recently, G. Lan et al. (Nature Phys., 8:422-8, 2012) performed a detailed analysis of a stochastic model for the E. coli sensory network. They showed that accurate adaptatio","authors_text":"Lei-Han Tang, Shou-Wen Wang, Yueheng Lan","cross_cats":["cond-mat.stat-mech","stat.AP"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.SC","submitted_at":"2015-05-28T01:42:34Z","title":"Energy dissipation in an adaptive molecular circuit"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1505.07526","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:518079d36ef7c00ad7c25d74aa6508595cd75214b6c04a8d3eedbcc3ba80ba55","target":"record","created_at":"2026-05-18T01:23:18Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"721add7310b6f516efb858f682f0c4beaf9b86a4703d0dc4c6498176c1cb717f","cross_cats_sorted":["cond-mat.stat-mech","stat.AP"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.SC","submitted_at":"2015-05-28T01:42:34Z","title_canon_sha256":"518e0fb6dc7a0474608794f285cd372b13084121cf25183b803b8804b5afbbfa"},"schema_version":"1.0","source":{"id":"1505.07526","kind":"arxiv","version":1}},"canonical_sha256":"1cc2be5b4f995ac726c8bd8f4fd0a67f596200c7654b264732a3735d879cbd7e","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"1cc2be5b4f995ac726c8bd8f4fd0a67f596200c7654b264732a3735d879cbd7e","first_computed_at":"2026-05-18T01:23:18.818038Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:23:18.818038Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"luIsBspLHouYeuMjQnC8OfOo19k1VrKWtx1zHnwxVtVJcOcHc+575v0riub6cZ6gLGtZEVeYzyeVRtJf54HbAw==","signature_status":"signed_v1","signed_at":"2026-05-18T01:23:18.818510Z","signed_message":"canonical_sha256_bytes"},"source_id":"1505.07526","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:518079d36ef7c00ad7c25d74aa6508595cd75214b6c04a8d3eedbcc3ba80ba55","sha256:f89e1f4fc97a8d973a1d4ce370b1eda7e4f83d580c953a30a5a6701ea190403b"],"state_sha256":"396f8efc5dcc1cf9e7362ede8c3635fb5c21a08e5cca7ac58cc50451e7671afc"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"xXa8dQ4G42xeJKvCKcxYHfE9UsjrxOsAvziAHpBdbdugIFUO/vlwvi1BgnCF31biaq8rUCr98QB8nNg/Eu6PCA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-28T11:31:45.825110Z","bundle_sha256":"75264fd365c1f690deb6589a79c0f88811469f0a439914ed1b366434ed25f902"}}