{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2014:DTVJC7JTVI5PXD2T5YRV7CX5DN","short_pith_number":"pith:DTVJC7JT","schema_version":"1.0","canonical_sha256":"1cea917d33aa3afb8f53ee235f8afd1b4c9c0f29444765cb2a3f9831090feb8d","source":{"kind":"arxiv","id":"1408.4237","version":2},"attestation_state":"computed","paper":{"title":"Topology Regulation during Replication of the Kinetoplast DNA","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph","q-bio.SC"],"primary_cat":"cond-mat.soft","authors_text":"Davide Marenduzzo, Davide Michieletto, Matthew S. Turner","submitted_at":"2014-08-19T07:56:22Z","abstract_excerpt":"We study theoretically the replication of Kinetoplast DNA consisting of several thousands separate mini-circles found in organisms of the class Kinetoplastida. When the cell is not actively dividing these are topologically connected in a marginally linked network of rings with only one connected component. During cell division each mini-circle is removed from the network, duplicated and then re-attached, along with its progeny. We study this process under the hypothesis that there is a coupling between the topological state of the mini-circles and the expression of genetic information encoded "},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1408.4237","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.soft","submitted_at":"2014-08-19T07:56:22Z","cross_cats_sorted":["physics.bio-ph","q-bio.SC"],"title_canon_sha256":"b9d706da4cadb86169cae617b65696b0e5be67855ae736d6c8ccc6baf977b783","abstract_canon_sha256":"cd27f6bae3e05893eddafb2d71285112eb22dd37be540e14ebbf8620e4dae7d2"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T02:44:48.796339Z","signature_b64":"cTynY/Tu0hybPyTD13bdiSmgI/8aCdN5xlwXFy0BvF3y1MLXO4D0lWzVVmxSmgcMf1zy4qod6pDnf0waKVkxDw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"1cea917d33aa3afb8f53ee235f8afd1b4c9c0f29444765cb2a3f9831090feb8d","last_reissued_at":"2026-05-18T02:44:48.795892Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T02:44:48.795892Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Topology Regulation during Replication of the Kinetoplast DNA","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph","q-bio.SC"],"primary_cat":"cond-mat.soft","authors_text":"Davide Marenduzzo, Davide Michieletto, Matthew S. Turner","submitted_at":"2014-08-19T07:56:22Z","abstract_excerpt":"We study theoretically the replication of Kinetoplast DNA consisting of several thousands separate mini-circles found in organisms of the class Kinetoplastida. When the cell is not actively dividing these are topologically connected in a marginally linked network of rings with only one connected component. During cell division each mini-circle is removed from the network, duplicated and then re-attached, along with its progeny. We study this process under the hypothesis that there is a coupling between the topological state of the mini-circles and the expression of genetic information encoded "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1408.4237","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1408.4237","created_at":"2026-05-18T02:44:48.795954+00:00"},{"alias_kind":"arxiv_version","alias_value":"1408.4237v2","created_at":"2026-05-18T02:44:48.795954+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1408.4237","created_at":"2026-05-18T02:44:48.795954+00:00"},{"alias_kind":"pith_short_12","alias_value":"DTVJC7JTVI5P","created_at":"2026-05-18T12:28:25.294606+00:00"},{"alias_kind":"pith_short_16","alias_value":"DTVJC7JTVI5PXD2T","created_at":"2026-05-18T12:28:25.294606+00:00"},{"alias_kind":"pith_short_8","alias_value":"DTVJC7JT","created_at":"2026-05-18T12:28:25.294606+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/DTVJC7JTVI5PXD2T5YRV7CX5DN","json":"https://pith.science/pith/DTVJC7JTVI5PXD2T5YRV7CX5DN.json","graph_json":"https://pith.science/api/pith-number/DTVJC7JTVI5PXD2T5YRV7CX5DN/graph.json","events_json":"https://pith.science/api/pith-number/DTVJC7JTVI5PXD2T5YRV7CX5DN/events.json","paper":"https://pith.science/paper/DTVJC7JT"},"agent_actions":{"view_html":"https://pith.science/pith/DTVJC7JTVI5PXD2T5YRV7CX5DN","download_json":"https://pith.science/pith/DTVJC7JTVI5PXD2T5YRV7CX5DN.json","view_paper":"https://pith.science/paper/DTVJC7JT","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1408.4237&json=true","fetch_graph":"https://pith.science/api/pith-number/DTVJC7JTVI5PXD2T5YRV7CX5DN/graph.json","fetch_events":"https://pith.science/api/pith-number/DTVJC7JTVI5PXD2T5YRV7CX5DN/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/DTVJC7JTVI5PXD2T5YRV7CX5DN/action/timestamp_anchor","attest_storage":"https://pith.science/pith/DTVJC7JTVI5PXD2T5YRV7CX5DN/action/storage_attestation","attest_author":"https://pith.science/pith/DTVJC7JTVI5PXD2T5YRV7CX5DN/action/author_attestation","sign_citation":"https://pith.science/pith/DTVJC7JTVI5PXD2T5YRV7CX5DN/action/citation_signature","submit_replication":"https://pith.science/pith/DTVJC7JTVI5PXD2T5YRV7CX5DN/action/replication_record"}},"created_at":"2026-05-18T02:44:48.795954+00:00","updated_at":"2026-05-18T02:44:48.795954+00:00"}