{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2016:DUCM4T3VNMAJFR7UVQH6MRVJ5U","short_pith_number":"pith:DUCM4T3V","canonical_record":{"source":{"id":"1602.04721","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2016-02-15T16:14:25Z","cross_cats_sorted":["q-bio.PE"],"title_canon_sha256":"6574dd0d3fdf8efc0ed1a279f7cd21d2ecefe9a76ecca0da9ccbbbeb47bf6a07","abstract_canon_sha256":"dad05e4ac1699bbbde98e28e236f0c53d578e68e3e1a9f0a93a51ab1851da5b7"},"schema_version":"1.0"},"canonical_sha256":"1d04ce4f756b0092c7f4ac0fe646a9ed27151553d032203132221bb7423b1dbc","source":{"kind":"arxiv","id":"1602.04721","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1602.04721","created_at":"2026-05-18T01:20:22Z"},{"alias_kind":"arxiv_version","alias_value":"1602.04721v1","created_at":"2026-05-18T01:20:22Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1602.04721","created_at":"2026-05-18T01:20:22Z"},{"alias_kind":"pith_short_12","alias_value":"DUCM4T3VNMAJ","created_at":"2026-05-18T12:30:12Z"},{"alias_kind":"pith_short_16","alias_value":"DUCM4T3VNMAJFR7U","created_at":"2026-05-18T12:30:12Z"},{"alias_kind":"pith_short_8","alias_value":"DUCM4T3V","created_at":"2026-05-18T12:30:12Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2016:DUCM4T3VNMAJFR7UVQH6MRVJ5U","target":"record","payload":{"canonical_record":{"source":{"id":"1602.04721","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2016-02-15T16:14:25Z","cross_cats_sorted":["q-bio.PE"],"title_canon_sha256":"6574dd0d3fdf8efc0ed1a279f7cd21d2ecefe9a76ecca0da9ccbbbeb47bf6a07","abstract_canon_sha256":"dad05e4ac1699bbbde98e28e236f0c53d578e68e3e1a9f0a93a51ab1851da5b7"},"schema_version":"1.0"},"canonical_sha256":"1d04ce4f756b0092c7f4ac0fe646a9ed27151553d032203132221bb7423b1dbc","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:20:22.690795Z","signature_b64":"WD+QDJfdonW57m8Ul1vsSiTPUFOKRo5IjvkO2fMcpRKwsMJ02IojDTeN+sP9HDKpJiD2C/hEyJwjJNApGDIPAw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"1d04ce4f756b0092c7f4ac0fe646a9ed27151553d032203132221bb7423b1dbc","last_reissued_at":"2026-05-18T01:20:22.690069Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:20:22.690069Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1602.04721","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:20:22Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"iZj0Yf0t/QotAOmzWqLk0BvJNPktH4sqEfD6Ce7SxdUM9p8dZRjHfJf0UUA+zNBCxVecHoVt5+kNNeThq7dPCA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-31T17:58:59.554967Z"},"content_sha256":"2d45ca3162fcaf04826db0c57721d12764a444f7fbe620c554c4d82a1093c5ea","schema_version":"1.0","event_id":"sha256:2d45ca3162fcaf04826db0c57721d12764a444f7fbe620c554c4d82a1093c5ea"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2016:DUCM4T3VNMAJFR7UVQH6MRVJ5U","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Evaluating hospital infection control measures for antimicrobial-resistant pathogens using stochastic transmission models: application to Vancomycin-Resistant Enterococci in intensive care units","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.PE"],"primary_cat":"stat.AP","authors_text":"Ben S. Cooper, Philip D. O'Neill, Sheryl L. Rifas-Shiman, Susan S. Huang, Theodore Kypraios, Yinghui Wei","submitted_at":"2016-02-15T16:14:25Z","abstract_excerpt":"Nosocomial pathogens such as Methicillin-Resistant {\\em Staphylococcus aureus} (MRSA) and Vancomycin-resistant {\\em Enterococci} (VRE) are the cause of significant morbidity and mortality among hospital patients. It is important to be able to assess the efficacy of control measures using data on patient outcomes. In this paper we describe methods for analysing such data using patient-level stochastic models which seek to describe the underlying unobserved process of transmission. The methods are applied to detailed longitudinal patient-level data on VRE from a study in a US hospital with eight"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1602.04721","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:20:22Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"uwvkfmuSsYHi36JFKTVq7VrkVp2CiBJujuEuLk3zYbT5sVtvVkezxImhQo/CeF4yrhuBtHWDxZlXhq52dsq8AQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-31T17:58:59.555561Z"},"content_sha256":"d23ea3ad70074d100de37c7362109afce8ef7e95b7bad267074658d0f0b9c816","schema_version":"1.0","event_id":"sha256:d23ea3ad70074d100de37c7362109afce8ef7e95b7bad267074658d0f0b9c816"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/DUCM4T3VNMAJFR7UVQH6MRVJ5U/bundle.json","state_url":"https://pith.science/pith/DUCM4T3VNMAJFR7UVQH6MRVJ5U/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/DUCM4T3VNMAJFR7UVQH6MRVJ5U/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-31T17:58:59Z","links":{"resolver":"https://pith.science/pith/DUCM4T3VNMAJFR7UVQH6MRVJ5U","bundle":"https://pith.science/pith/DUCM4T3VNMAJFR7UVQH6MRVJ5U/bundle.json","state":"https://pith.science/pith/DUCM4T3VNMAJFR7UVQH6MRVJ5U/state.json","well_known_bundle":"https://pith.science/.well-known/pith/DUCM4T3VNMAJFR7UVQH6MRVJ5U/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2016:DUCM4T3VNMAJFR7UVQH6MRVJ5U","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"dad05e4ac1699bbbde98e28e236f0c53d578e68e3e1a9f0a93a51ab1851da5b7","cross_cats_sorted":["q-bio.PE"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2016-02-15T16:14:25Z","title_canon_sha256":"6574dd0d3fdf8efc0ed1a279f7cd21d2ecefe9a76ecca0da9ccbbbeb47bf6a07"},"schema_version":"1.0","source":{"id":"1602.04721","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1602.04721","created_at":"2026-05-18T01:20:22Z"},{"alias_kind":"arxiv_version","alias_value":"1602.04721v1","created_at":"2026-05-18T01:20:22Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1602.04721","created_at":"2026-05-18T01:20:22Z"},{"alias_kind":"pith_short_12","alias_value":"DUCM4T3VNMAJ","created_at":"2026-05-18T12:30:12Z"},{"alias_kind":"pith_short_16","alias_value":"DUCM4T3VNMAJFR7U","created_at":"2026-05-18T12:30:12Z"},{"alias_kind":"pith_short_8","alias_value":"DUCM4T3V","created_at":"2026-05-18T12:30:12Z"}],"graph_snapshots":[{"event_id":"sha256:d23ea3ad70074d100de37c7362109afce8ef7e95b7bad267074658d0f0b9c816","target":"graph","created_at":"2026-05-18T01:20:22Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Nosocomial pathogens such as Methicillin-Resistant {\\em Staphylococcus aureus} (MRSA) and Vancomycin-resistant {\\em Enterococci} (VRE) are the cause of significant morbidity and mortality among hospital patients. It is important to be able to assess the efficacy of control measures using data on patient outcomes. In this paper we describe methods for analysing such data using patient-level stochastic models which seek to describe the underlying unobserved process of transmission. The methods are applied to detailed longitudinal patient-level data on VRE from a study in a US hospital with eight","authors_text":"Ben S. Cooper, Philip D. O'Neill, Sheryl L. Rifas-Shiman, Susan S. Huang, Theodore Kypraios, Yinghui Wei","cross_cats":["q-bio.PE"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2016-02-15T16:14:25Z","title":"Evaluating hospital infection control measures for antimicrobial-resistant pathogens using stochastic transmission models: application to Vancomycin-Resistant Enterococci in intensive care units"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1602.04721","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:2d45ca3162fcaf04826db0c57721d12764a444f7fbe620c554c4d82a1093c5ea","target":"record","created_at":"2026-05-18T01:20:22Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"dad05e4ac1699bbbde98e28e236f0c53d578e68e3e1a9f0a93a51ab1851da5b7","cross_cats_sorted":["q-bio.PE"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2016-02-15T16:14:25Z","title_canon_sha256":"6574dd0d3fdf8efc0ed1a279f7cd21d2ecefe9a76ecca0da9ccbbbeb47bf6a07"},"schema_version":"1.0","source":{"id":"1602.04721","kind":"arxiv","version":1}},"canonical_sha256":"1d04ce4f756b0092c7f4ac0fe646a9ed27151553d032203132221bb7423b1dbc","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"1d04ce4f756b0092c7f4ac0fe646a9ed27151553d032203132221bb7423b1dbc","first_computed_at":"2026-05-18T01:20:22.690069Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:20:22.690069Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"WD+QDJfdonW57m8Ul1vsSiTPUFOKRo5IjvkO2fMcpRKwsMJ02IojDTeN+sP9HDKpJiD2C/hEyJwjJNApGDIPAw==","signature_status":"signed_v1","signed_at":"2026-05-18T01:20:22.690795Z","signed_message":"canonical_sha256_bytes"},"source_id":"1602.04721","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:2d45ca3162fcaf04826db0c57721d12764a444f7fbe620c554c4d82a1093c5ea","sha256:d23ea3ad70074d100de37c7362109afce8ef7e95b7bad267074658d0f0b9c816"],"state_sha256":"a3d6c1d6e0175a8d2ebcf58008ada83a2ceeb1056c7c72b050cbf1abbf9d11f0"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"H9FuGIG8xtK4W1+nQ9Q0hhlWoHpd18Bu5u6xXvtlwZlSVbsBaRPxGZJJbnMoJtsExsVkYB+YqORynVZDlZX9Cw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-31T17:58:59.559146Z","bundle_sha256":"9e0fb34b4a8d602921f3af03adb0070e2b8ff6448859f2067e9f7246580f7fb8"}}