{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2016:DWC6LGIQF6VFFTN2AZJQE5ECZC","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"024375d7d9ac1dfe7bdd7a361568b10d760f263c6dbe946d1353eb4a735bce6d","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2016-06-02T22:51:52Z","title_canon_sha256":"60a9c3aedc2cce84735d9b5f1978d062761846283f2f8fe78f88147cedb73f0b"},"schema_version":"1.0","source":{"id":"1606.00928","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1606.00928","created_at":"2026-05-18T01:10:47Z"},{"alias_kind":"arxiv_version","alias_value":"1606.00928v1","created_at":"2026-05-18T01:10:47Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1606.00928","created_at":"2026-05-18T01:10:47Z"},{"alias_kind":"pith_short_12","alias_value":"DWC6LGIQF6VF","created_at":"2026-05-18T12:30:12Z"},{"alias_kind":"pith_short_16","alias_value":"DWC6LGIQF6VFFTN2","created_at":"2026-05-18T12:30:12Z"},{"alias_kind":"pith_short_8","alias_value":"DWC6LGIQ","created_at":"2026-05-18T12:30:12Z"}],"graph_snapshots":[{"event_id":"sha256:93e513c94573b371ce6d3443dd99a402c660b3435e6e536214aef86b36c88d0f","target":"graph","created_at":"2026-05-18T01:10:47Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Genetic regulatory networks with adaptive responses are widely studied in biology. Usually, models consisting only of a few nodes have been considered. They present one input receptor for activation and one output node where the adaptive response is computed. In this work, we design genetic regulatory networks with many receptors and many output nodes able to produce delayed adaptive responses. This design is performed by using an evolutionary algorithm of mutations and selections that minimizes an error function defined by the adaptive response in signal shapes. We present several examples of","authors_text":"Masayo Inoue, Pablo Kaluza","cross_cats":["physics.bio-ph"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2016-06-02T22:51:52Z","title":"Design of artificial genetic regulatory networks with multiple delayed adaptive responses"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1606.00928","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:b983e0da7ec3b18efe73472d8c01350f0a47c25c5e48b966e168454f6512e4da","target":"record","created_at":"2026-05-18T01:10:47Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"024375d7d9ac1dfe7bdd7a361568b10d760f263c6dbe946d1353eb4a735bce6d","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2016-06-02T22:51:52Z","title_canon_sha256":"60a9c3aedc2cce84735d9b5f1978d062761846283f2f8fe78f88147cedb73f0b"},"schema_version":"1.0","source":{"id":"1606.00928","kind":"arxiv","version":1}},"canonical_sha256":"1d85e599102faa52cdba0653027482c8a3e37398d42cc2069c164591c6d5ee17","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"1d85e599102faa52cdba0653027482c8a3e37398d42cc2069c164591c6d5ee17","first_computed_at":"2026-05-18T01:10:47.401290Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:10:47.401290Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"3c5SsdYQL2ifrHhcOk+UcMPMzCYrza5GCurFBgnjEFBUTAu6b6du7G2uD2mffG7DiO/4AqEtRX2mrYvfoySWDA==","signature_status":"signed_v1","signed_at":"2026-05-18T01:10:47.401745Z","signed_message":"canonical_sha256_bytes"},"source_id":"1606.00928","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:b983e0da7ec3b18efe73472d8c01350f0a47c25c5e48b966e168454f6512e4da","sha256:93e513c94573b371ce6d3443dd99a402c660b3435e6e536214aef86b36c88d0f"],"state_sha256":"652dfe2777235b5719c17b154ab6112205c6e967bd84bf607e92b48512690329"}