{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2019:DYE3GS3VLWA5MJSJD6HFZ6JGVB","short_pith_number":"pith:DYE3GS3V","schema_version":"1.0","canonical_sha256":"1e09b34b755d81d626491f8e5cf926a8640593a6c28ab29996ca1004dc74bd14","source":{"kind":"arxiv","id":"1903.07103","version":1},"attestation_state":"computed","paper":{"title":"The self-tuned sensitivity of circadian clocks","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph"],"primary_cat":"q-bio.MN","authors_text":"Arvind Murugan, Gopal Pattanayak, Kabir Husain, Michael J Rust, Weerapat Pittayakanchit","submitted_at":"2019-03-17T15:06:23Z","abstract_excerpt":"Living organisms need to be sensitive to a changing environment while also ignoring uninformative environmental fluctuations. Here, we show that the circadian clock in \\textit{Synechococcus elongatus} can naturally tune its environmental sensitivity, through a clock-metabolism coupling quantified in recent experiments. The metabolic coupling can detect mismatch between clock predictions and the day-night light cycle, and temporarily raise the clock's sensitivity to light changes and thus entrain faster. We also analyze analogous behavior in recent experiments on switching between slow and fast"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1903.07103","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2019-03-17T15:06:23Z","cross_cats_sorted":["physics.bio-ph"],"title_canon_sha256":"4da0651395b758358395349ef1f856f01f3a483da53524bcdfb603cc9a4952d0","abstract_canon_sha256":"6470ea36628e6f45b232df51b7946583ba74e57d229b4bb8c4220a53eb2d01f4"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-17T23:51:04.217520Z","signature_b64":"NV4QQJhWQer9he+Bd4C0QLPohIVLkbkm6v3tOeGnd8vNpguS+DDGtz5UATbR+OvSuTilhOsp8DPUcCFriohmCA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"1e09b34b755d81d626491f8e5cf926a8640593a6c28ab29996ca1004dc74bd14","last_reissued_at":"2026-05-17T23:51:04.216834Z","signature_status":"signed_v1","first_computed_at":"2026-05-17T23:51:04.216834Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"The self-tuned sensitivity of circadian clocks","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph"],"primary_cat":"q-bio.MN","authors_text":"Arvind Murugan, Gopal Pattanayak, Kabir Husain, Michael J Rust, Weerapat Pittayakanchit","submitted_at":"2019-03-17T15:06:23Z","abstract_excerpt":"Living organisms need to be sensitive to a changing environment while also ignoring uninformative environmental fluctuations. Here, we show that the circadian clock in \\textit{Synechococcus elongatus} can naturally tune its environmental sensitivity, through a clock-metabolism coupling quantified in recent experiments. The metabolic coupling can detect mismatch between clock predictions and the day-night light cycle, and temporarily raise the clock's sensitivity to light changes and thus entrain faster. We also analyze analogous behavior in recent experiments on switching between slow and fast"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1903.07103","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1903.07103","created_at":"2026-05-17T23:51:04.216942+00:00"},{"alias_kind":"arxiv_version","alias_value":"1903.07103v1","created_at":"2026-05-17T23:51:04.216942+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1903.07103","created_at":"2026-05-17T23:51:04.216942+00:00"},{"alias_kind":"pith_short_12","alias_value":"DYE3GS3VLWA5","created_at":"2026-05-18T12:33:15.570797+00:00"},{"alias_kind":"pith_short_16","alias_value":"DYE3GS3VLWA5MJSJ","created_at":"2026-05-18T12:33:15.570797+00:00"},{"alias_kind":"pith_short_8","alias_value":"DYE3GS3V","created_at":"2026-05-18T12:33:15.570797+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/DYE3GS3VLWA5MJSJD6HFZ6JGVB","json":"https://pith.science/pith/DYE3GS3VLWA5MJSJD6HFZ6JGVB.json","graph_json":"https://pith.science/api/pith-number/DYE3GS3VLWA5MJSJD6HFZ6JGVB/graph.json","events_json":"https://pith.science/api/pith-number/DYE3GS3VLWA5MJSJD6HFZ6JGVB/events.json","paper":"https://pith.science/paper/DYE3GS3V"},"agent_actions":{"view_html":"https://pith.science/pith/DYE3GS3VLWA5MJSJD6HFZ6JGVB","download_json":"https://pith.science/pith/DYE3GS3VLWA5MJSJD6HFZ6JGVB.json","view_paper":"https://pith.science/paper/DYE3GS3V","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1903.07103&json=true","fetch_graph":"https://pith.science/api/pith-number/DYE3GS3VLWA5MJSJD6HFZ6JGVB/graph.json","fetch_events":"https://pith.science/api/pith-number/DYE3GS3VLWA5MJSJD6HFZ6JGVB/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/DYE3GS3VLWA5MJSJD6HFZ6JGVB/action/timestamp_anchor","attest_storage":"https://pith.science/pith/DYE3GS3VLWA5MJSJD6HFZ6JGVB/action/storage_attestation","attest_author":"https://pith.science/pith/DYE3GS3VLWA5MJSJD6HFZ6JGVB/action/author_attestation","sign_citation":"https://pith.science/pith/DYE3GS3VLWA5MJSJD6HFZ6JGVB/action/citation_signature","submit_replication":"https://pith.science/pith/DYE3GS3VLWA5MJSJD6HFZ6JGVB/action/replication_record"}},"created_at":"2026-05-17T23:51:04.216942+00:00","updated_at":"2026-05-17T23:51:04.216942+00:00"}