{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2019:DYE3GS3VLWA5MJSJD6HFZ6JGVB","short_pith_number":"pith:DYE3GS3V","canonical_record":{"source":{"id":"1903.07103","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2019-03-17T15:06:23Z","cross_cats_sorted":["physics.bio-ph"],"title_canon_sha256":"4da0651395b758358395349ef1f856f01f3a483da53524bcdfb603cc9a4952d0","abstract_canon_sha256":"6470ea36628e6f45b232df51b7946583ba74e57d229b4bb8c4220a53eb2d01f4"},"schema_version":"1.0"},"canonical_sha256":"1e09b34b755d81d626491f8e5cf926a8640593a6c28ab29996ca1004dc74bd14","source":{"kind":"arxiv","id":"1903.07103","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1903.07103","created_at":"2026-05-17T23:51:04Z"},{"alias_kind":"arxiv_version","alias_value":"1903.07103v1","created_at":"2026-05-17T23:51:04Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1903.07103","created_at":"2026-05-17T23:51:04Z"},{"alias_kind":"pith_short_12","alias_value":"DYE3GS3VLWA5","created_at":"2026-05-18T12:33:15Z"},{"alias_kind":"pith_short_16","alias_value":"DYE3GS3VLWA5MJSJ","created_at":"2026-05-18T12:33:15Z"},{"alias_kind":"pith_short_8","alias_value":"DYE3GS3V","created_at":"2026-05-18T12:33:15Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2019:DYE3GS3VLWA5MJSJD6HFZ6JGVB","target":"record","payload":{"canonical_record":{"source":{"id":"1903.07103","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2019-03-17T15:06:23Z","cross_cats_sorted":["physics.bio-ph"],"title_canon_sha256":"4da0651395b758358395349ef1f856f01f3a483da53524bcdfb603cc9a4952d0","abstract_canon_sha256":"6470ea36628e6f45b232df51b7946583ba74e57d229b4bb8c4220a53eb2d01f4"},"schema_version":"1.0"},"canonical_sha256":"1e09b34b755d81d626491f8e5cf926a8640593a6c28ab29996ca1004dc74bd14","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-17T23:51:04.217520Z","signature_b64":"NV4QQJhWQer9he+Bd4C0QLPohIVLkbkm6v3tOeGnd8vNpguS+DDGtz5UATbR+OvSuTilhOsp8DPUcCFriohmCA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"1e09b34b755d81d626491f8e5cf926a8640593a6c28ab29996ca1004dc74bd14","last_reissued_at":"2026-05-17T23:51:04.216834Z","signature_status":"signed_v1","first_computed_at":"2026-05-17T23:51:04.216834Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1903.07103","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:51:04Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"2N3lcMJbuzQTBOLMwG2RdroY8PN2hPasja47w4G27Auy5XYF5I+qpBWsaPnBHjAqtjQDgr9CXTMey7U2jvgBBg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-20T10:45:52.699800Z"},"content_sha256":"a34984a7c4dea631f8e29e01520b9aab4b8517a78c6fe2182b577ee5a3d3024f","schema_version":"1.0","event_id":"sha256:a34984a7c4dea631f8e29e01520b9aab4b8517a78c6fe2182b577ee5a3d3024f"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2019:DYE3GS3VLWA5MJSJD6HFZ6JGVB","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"The self-tuned sensitivity of circadian clocks","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph"],"primary_cat":"q-bio.MN","authors_text":"Arvind Murugan, Gopal Pattanayak, Kabir Husain, Michael J Rust, Weerapat Pittayakanchit","submitted_at":"2019-03-17T15:06:23Z","abstract_excerpt":"Living organisms need to be sensitive to a changing environment while also ignoring uninformative environmental fluctuations. Here, we show that the circadian clock in \\textit{Synechococcus elongatus} can naturally tune its environmental sensitivity, through a clock-metabolism coupling quantified in recent experiments. The metabolic coupling can detect mismatch between clock predictions and the day-night light cycle, and temporarily raise the clock's sensitivity to light changes and thus entrain faster. We also analyze analogous behavior in recent experiments on switching between slow and fast"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1903.07103","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:51:04Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"kiSZHpl8G4tB9mcIi9/oICGTTgUg07BEDs0zmz2xWJD/uvRLAw1qTi8m+9+YbbiA24i/+i6HXET9b+bp9EijAg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-20T10:45:52.700146Z"},"content_sha256":"b0540a71e8552f7f91a0b17e478825bc55d8db3f9bb1251012e231de3a84f72b","schema_version":"1.0","event_id":"sha256:b0540a71e8552f7f91a0b17e478825bc55d8db3f9bb1251012e231de3a84f72b"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/DYE3GS3VLWA5MJSJD6HFZ6JGVB/bundle.json","state_url":"https://pith.science/pith/DYE3GS3VLWA5MJSJD6HFZ6JGVB/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/DYE3GS3VLWA5MJSJD6HFZ6JGVB/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-20T10:45:52Z","links":{"resolver":"https://pith.science/pith/DYE3GS3VLWA5MJSJD6HFZ6JGVB","bundle":"https://pith.science/pith/DYE3GS3VLWA5MJSJD6HFZ6JGVB/bundle.json","state":"https://pith.science/pith/DYE3GS3VLWA5MJSJD6HFZ6JGVB/state.json","well_known_bundle":"https://pith.science/.well-known/pith/DYE3GS3VLWA5MJSJD6HFZ6JGVB/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2019:DYE3GS3VLWA5MJSJD6HFZ6JGVB","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"6470ea36628e6f45b232df51b7946583ba74e57d229b4bb8c4220a53eb2d01f4","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2019-03-17T15:06:23Z","title_canon_sha256":"4da0651395b758358395349ef1f856f01f3a483da53524bcdfb603cc9a4952d0"},"schema_version":"1.0","source":{"id":"1903.07103","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1903.07103","created_at":"2026-05-17T23:51:04Z"},{"alias_kind":"arxiv_version","alias_value":"1903.07103v1","created_at":"2026-05-17T23:51:04Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1903.07103","created_at":"2026-05-17T23:51:04Z"},{"alias_kind":"pith_short_12","alias_value":"DYE3GS3VLWA5","created_at":"2026-05-18T12:33:15Z"},{"alias_kind":"pith_short_16","alias_value":"DYE3GS3VLWA5MJSJ","created_at":"2026-05-18T12:33:15Z"},{"alias_kind":"pith_short_8","alias_value":"DYE3GS3V","created_at":"2026-05-18T12:33:15Z"}],"graph_snapshots":[{"event_id":"sha256:b0540a71e8552f7f91a0b17e478825bc55d8db3f9bb1251012e231de3a84f72b","target":"graph","created_at":"2026-05-17T23:51:04Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Living organisms need to be sensitive to a changing environment while also ignoring uninformative environmental fluctuations. Here, we show that the circadian clock in \\textit{Synechococcus elongatus} can naturally tune its environmental sensitivity, through a clock-metabolism coupling quantified in recent experiments. The metabolic coupling can detect mismatch between clock predictions and the day-night light cycle, and temporarily raise the clock's sensitivity to light changes and thus entrain faster. We also analyze analogous behavior in recent experiments on switching between slow and fast","authors_text":"Arvind Murugan, Gopal Pattanayak, Kabir Husain, Michael J Rust, Weerapat Pittayakanchit","cross_cats":["physics.bio-ph"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2019-03-17T15:06:23Z","title":"The self-tuned sensitivity of circadian clocks"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1903.07103","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:a34984a7c4dea631f8e29e01520b9aab4b8517a78c6fe2182b577ee5a3d3024f","target":"record","created_at":"2026-05-17T23:51:04Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"6470ea36628e6f45b232df51b7946583ba74e57d229b4bb8c4220a53eb2d01f4","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2019-03-17T15:06:23Z","title_canon_sha256":"4da0651395b758358395349ef1f856f01f3a483da53524bcdfb603cc9a4952d0"},"schema_version":"1.0","source":{"id":"1903.07103","kind":"arxiv","version":1}},"canonical_sha256":"1e09b34b755d81d626491f8e5cf926a8640593a6c28ab29996ca1004dc74bd14","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"1e09b34b755d81d626491f8e5cf926a8640593a6c28ab29996ca1004dc74bd14","first_computed_at":"2026-05-17T23:51:04.216834Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-17T23:51:04.216834Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"NV4QQJhWQer9he+Bd4C0QLPohIVLkbkm6v3tOeGnd8vNpguS+DDGtz5UATbR+OvSuTilhOsp8DPUcCFriohmCA==","signature_status":"signed_v1","signed_at":"2026-05-17T23:51:04.217520Z","signed_message":"canonical_sha256_bytes"},"source_id":"1903.07103","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:a34984a7c4dea631f8e29e01520b9aab4b8517a78c6fe2182b577ee5a3d3024f","sha256:b0540a71e8552f7f91a0b17e478825bc55d8db3f9bb1251012e231de3a84f72b"],"state_sha256":"b3bd91b723660af6bc150b1b0fc15275bc26cf16a4d6e466b079904c6756867d"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"kJuyQjbnbIrDRsJZbmw95NwSMd8CmiY2LL5lTmfyVzvabEWHUoXz+972rdeycNfp7mBuoUI/ZuX6nIkaV19JAQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-20T10:45:52.702122Z","bundle_sha256":"a9f230dd98feabb7bf30ad6fa77049a48837e23ab8190f012ee7211ce4786c99"}}