{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:DYPFLUIE5WZGOHZ3PLOSU2RPZG","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"27f8d808fb89e949970e55227aff362f236b93a7b858dc44cc224318a0a0cda9","cross_cats_sorted":["physics.bio-ph","q-bio.QM"],"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"q-bio.MN","submitted_at":"2025-08-12T15:58:51Z","title_canon_sha256":"520794b744b0b884fe7c41b66d74370a0074c09c15ec2394717bfa7ef6e87d2a"},"schema_version":"1.0","source":{"id":"2508.09038","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2508.09038","created_at":"2026-07-05T11:52:38Z"},{"alias_kind":"arxiv_version","alias_value":"2508.09038v1","created_at":"2026-07-05T11:52:38Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2508.09038","created_at":"2026-07-05T11:52:38Z"},{"alias_kind":"pith_short_12","alias_value":"DYPFLUIE5WZG","created_at":"2026-07-05T11:52:38Z"},{"alias_kind":"pith_short_16","alias_value":"DYPFLUIE5WZGOHZ3","created_at":"2026-07-05T11:52:38Z"},{"alias_kind":"pith_short_8","alias_value":"DYPFLUIE","created_at":"2026-07-05T11:52:38Z"}],"graph_snapshots":[{"event_id":"sha256:ee71d117650165757ba3abd04f3b9abb89b0764662b1e7a3887366ec965352ae","target":"graph","created_at":"2026-07-05T11:52:38Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2508.09038/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Cell phenotype dynamic homeostasis contrasts with the inherent randomness of intracellular reactions. Although feedback control of master regulatory genes (MRG) is a key strategy for maintaining gene network expression ranges limited, understanding the quantitative constraints and corresponding mechanisms enabling such a dynamic stability under noise remains elusive. Here we model MRG expression as a stochastic process and downstream genes as sensors which response conditionally induce MRG activity. We show that at homeostatic regime: i. the trajectories of the MRG expression levels can be adj","authors_text":"Alexandre Ferreira Ramos, Ammar Alsinai, Cyro von Zuben de Valega Negr\\~ao, Guilherme Giovanini","cross_cats":["physics.bio-ph","q-bio.QM"],"headline":"","license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"q-bio.MN","submitted_at":"2025-08-12T15:58:51Z","title":"A control theoretical approach to gene regulation raises quantitative constraints for dynamic homeostasis in stochastic gene expression"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2508.09038","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:467b9fe45c135e3e60eb7458ed2cddd812cfc895c4e20b4d010752159ec01fcc","target":"record","created_at":"2026-07-05T11:52:38Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"27f8d808fb89e949970e55227aff362f236b93a7b858dc44cc224318a0a0cda9","cross_cats_sorted":["physics.bio-ph","q-bio.QM"],"license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","primary_cat":"q-bio.MN","submitted_at":"2025-08-12T15:58:51Z","title_canon_sha256":"520794b744b0b884fe7c41b66d74370a0074c09c15ec2394717bfa7ef6e87d2a"},"schema_version":"1.0","source":{"id":"2508.09038","kind":"arxiv","version":1}},"canonical_sha256":"1e1e55d104edb2671f3b7add2a6a2fc98fb103323299573a500521ed6aff0c46","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"1e1e55d104edb2671f3b7add2a6a2fc98fb103323299573a500521ed6aff0c46","first_computed_at":"2026-07-05T11:52:38.843381Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T11:52:38.843381Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"xPNmIRVltmy3ikY9wveyUCFwRb+KCn38xRAVWplPZSraHgOMvYLaKjm7doww9Z8OVNWUvLki1mMhg3/DHeyzBw==","signature_status":"signed_v1","signed_at":"2026-07-05T11:52:38.843864Z","signed_message":"canonical_sha256_bytes"},"source_id":"2508.09038","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:467b9fe45c135e3e60eb7458ed2cddd812cfc895c4e20b4d010752159ec01fcc","sha256:ee71d117650165757ba3abd04f3b9abb89b0764662b1e7a3887366ec965352ae"],"state_sha256":"52589a292db3f641bffed1b9f56dacd576af6806b5f9a12f356ae94c736a1f72"}