{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2024:E22EZD6HZNHE62KBQZDNCYNHQI","short_pith_number":"pith:E22EZD6H","schema_version":"1.0","canonical_sha256":"26b44c8fc7cb4e4f69418646d161a7823e9f6ef4875599a3781cdd7b370daf1e","source":{"kind":"arxiv","id":"2412.18935","version":1},"attestation_state":"computed","paper":{"title":"Label-free SERS Discrimination of Proline from Hydroxylated Proline at Single-molecule Level Assisted by a Deep Learning Model","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["cs.LG","physics.bio-ph"],"primary_cat":"physics.chem-ph","authors_text":"Francesco De Angelis, Jianan Huang, Kuo Zhan, Pei-Lin Xin, Shuai Li, Yingqi Zhao, Zuyan Chen","submitted_at":"2024-12-25T15:46:52Z","abstract_excerpt":"Discriminating the low-abundance hydroxylated proline from hydroxylated proline is crucial for monitoring diseases and eval-uating therapeutic outcomes that require single-molecule sensors. While the plasmonic nanopore sensor can detect the hydrox-ylation with single-molecule sensitivity by surface enhanced Raman spectroscopy (SERS), it suffers from intrinsic fluctuations of single-molecule signals as well as strong interference from citrates. Here, we used the occurrence frequency histogram of the single-molecule SERS peaks to extract overall dataset spectral features, overcome the signal flu"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"2412.18935","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.chem-ph","submitted_at":"2024-12-25T15:46:52Z","cross_cats_sorted":["cs.LG","physics.bio-ph"],"title_canon_sha256":"75106e38d9d644bb8d013010ded428f672e52e2f850bee5f777689576dbe53be","abstract_canon_sha256":"6fb2100a0cb871c64060bb8a6cffb5b154f48b38938730724361ed3efa7f0387"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T09:54:13.401140Z","signature_b64":"fOfBqf1J7ibLTZaXxhHpXuUMgctVnKDhzmtFocdclno19nRaOxT2t5+XGePy6cthYiiXvZtZzzciQcjspVAVBA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"26b44c8fc7cb4e4f69418646d161a7823e9f6ef4875599a3781cdd7b370daf1e","last_reissued_at":"2026-07-05T09:54:13.400668Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T09:54:13.400668Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Label-free SERS Discrimination of Proline from Hydroxylated Proline at Single-molecule Level Assisted by a Deep Learning Model","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["cs.LG","physics.bio-ph"],"primary_cat":"physics.chem-ph","authors_text":"Francesco De Angelis, Jianan Huang, Kuo Zhan, Pei-Lin Xin, Shuai Li, Yingqi Zhao, Zuyan Chen","submitted_at":"2024-12-25T15:46:52Z","abstract_excerpt":"Discriminating the low-abundance hydroxylated proline from hydroxylated proline is crucial for monitoring diseases and eval-uating therapeutic outcomes that require single-molecule sensors. While the plasmonic nanopore sensor can detect the hydrox-ylation with single-molecule sensitivity by surface enhanced Raman spectroscopy (SERS), it suffers from intrinsic fluctuations of single-molecule signals as well as strong interference from citrates. Here, we used the occurrence frequency histogram of the single-molecule SERS peaks to extract overall dataset spectral features, overcome the signal flu"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2412.18935","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2412.18935/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"2412.18935","created_at":"2026-07-05T09:54:13.400732+00:00"},{"alias_kind":"arxiv_version","alias_value":"2412.18935v1","created_at":"2026-07-05T09:54:13.400732+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2412.18935","created_at":"2026-07-05T09:54:13.400732+00:00"},{"alias_kind":"pith_short_12","alias_value":"E22EZD6HZNHE","created_at":"2026-07-05T09:54:13.400732+00:00"},{"alias_kind":"pith_short_16","alias_value":"E22EZD6HZNHE62KB","created_at":"2026-07-05T09:54:13.400732+00:00"},{"alias_kind":"pith_short_8","alias_value":"E22EZD6H","created_at":"2026-07-05T09:54:13.400732+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/E22EZD6HZNHE62KBQZDNCYNHQI","json":"https://pith.science/pith/E22EZD6HZNHE62KBQZDNCYNHQI.json","graph_json":"https://pith.science/api/pith-number/E22EZD6HZNHE62KBQZDNCYNHQI/graph.json","events_json":"https://pith.science/api/pith-number/E22EZD6HZNHE62KBQZDNCYNHQI/events.json","paper":"https://pith.science/paper/E22EZD6H"},"agent_actions":{"view_html":"https://pith.science/pith/E22EZD6HZNHE62KBQZDNCYNHQI","download_json":"https://pith.science/pith/E22EZD6HZNHE62KBQZDNCYNHQI.json","view_paper":"https://pith.science/paper/E22EZD6H","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=2412.18935&json=true","fetch_graph":"https://pith.science/api/pith-number/E22EZD6HZNHE62KBQZDNCYNHQI/graph.json","fetch_events":"https://pith.science/api/pith-number/E22EZD6HZNHE62KBQZDNCYNHQI/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/E22EZD6HZNHE62KBQZDNCYNHQI/action/timestamp_anchor","attest_storage":"https://pith.science/pith/E22EZD6HZNHE62KBQZDNCYNHQI/action/storage_attestation","attest_author":"https://pith.science/pith/E22EZD6HZNHE62KBQZDNCYNHQI/action/author_attestation","sign_citation":"https://pith.science/pith/E22EZD6HZNHE62KBQZDNCYNHQI/action/citation_signature","submit_replication":"https://pith.science/pith/E22EZD6HZNHE62KBQZDNCYNHQI/action/replication_record"}},"created_at":"2026-07-05T09:54:13.400732+00:00","updated_at":"2026-07-05T09:54:13.400732+00:00"}