{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2010:E34VX2TDTBLAHE6FYFDMDKRKI5","short_pith_number":"pith:E34VX2TD","canonical_record":{"source":{"id":"1011.4382","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2010-11-19T10:24:36Z","cross_cats_sorted":["physics.bio-ph","q-bio.MN"],"title_canon_sha256":"180da4480053d090301f5370407bec2a7b5cd3e792084cf4543477b512867d2f","abstract_canon_sha256":"aa2fcb950c80681d6054c3b407c7055b51776a87b06feb61d58f7ff8444b7f1c"},"schema_version":"1.0"},"canonical_sha256":"26f95bea6398560393c5c146c1aa2a475c260e7161f41d142be767affa9a0b0e","source":{"kind":"arxiv","id":"1011.4382","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1011.4382","created_at":"2026-05-18T04:35:14Z"},{"alias_kind":"arxiv_version","alias_value":"1011.4382v1","created_at":"2026-05-18T04:35:14Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1011.4382","created_at":"2026-05-18T04:35:14Z"},{"alias_kind":"pith_short_12","alias_value":"E34VX2TDTBLA","created_at":"2026-05-18T12:26:06Z"},{"alias_kind":"pith_short_16","alias_value":"E34VX2TDTBLAHE6F","created_at":"2026-05-18T12:26:06Z"},{"alias_kind":"pith_short_8","alias_value":"E34VX2TD","created_at":"2026-05-18T12:26:06Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2010:E34VX2TDTBLAHE6FYFDMDKRKI5","target":"record","payload":{"canonical_record":{"source":{"id":"1011.4382","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2010-11-19T10:24:36Z","cross_cats_sorted":["physics.bio-ph","q-bio.MN"],"title_canon_sha256":"180da4480053d090301f5370407bec2a7b5cd3e792084cf4543477b512867d2f","abstract_canon_sha256":"aa2fcb950c80681d6054c3b407c7055b51776a87b06feb61d58f7ff8444b7f1c"},"schema_version":"1.0"},"canonical_sha256":"26f95bea6398560393c5c146c1aa2a475c260e7161f41d142be767affa9a0b0e","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T04:35:14.271941Z","signature_b64":"Gsyh6NcZVkbshrSR2fAmmu+qgguhhRZv0jKFD2Bv9B9b8C6xd+2K6j85YOZ+yJIlEySECmAR1iGytgYB2UkYBA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"26f95bea6398560393c5c146c1aa2a475c260e7161f41d142be767affa9a0b0e","last_reissued_at":"2026-05-18T04:35:14.271458Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T04:35:14.271458Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1011.4382","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:35:14Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"AiJCK3W3y6tgtL6D7Az/b0jZrjmLqkF2CPfFfVYr4kHJ8IMf93nZU8asqyLBglNsBCM6ZUBy/NuA9gA9nqpoDw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-21T01:35:08.945568Z"},"content_sha256":"1396702e44b81ecf8695f4b517ca1a3895410460a2f1d37b944d3389b0bd07c7","schema_version":"1.0","event_id":"sha256:1396702e44b81ecf8695f4b517ca1a3895410460a2f1d37b944d3389b0bd07c7"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2010:E34VX2TDTBLAHE6FYFDMDKRKI5","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"RecA-mediated homology search as a nearly optimal signal detection system","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph","q-bio.MN"],"primary_cat":"q-bio.BM","authors_text":"Tsvi Tlusty, Yonatan Savir","submitted_at":"2010-11-19T10:24:36Z","abstract_excerpt":"Homologous recombination facilitates the exchange of genetic material between homologous DNA molecules. This crucial process requires detecting a specific homologous DNA sequence within a huge variety of heterologous sequences. The detection is mediated by RecA in E. coli, or members of its superfamily in other organisms. Here we examine how well is the RecA-DNA interaction adjusted to its task. By formulating the DNA recognition process as a signal detection problem, we find the optimal value of binding energy that maximizes the ability to detect homologous sequences. We show that the experim"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1011.4382","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:35:14Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Zd2uuQn4ULOuCheI6OYSLAF5ApbhV5KY6rEcy/02noYQE5Xkzix00qlr3W8PMFV7283lFbCuqXyTjUeS38IUAg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-21T01:35:08.945923Z"},"content_sha256":"1ca9ff08f9ce24dfca8c902a0024c2f3b5899da925939605ac53153bb9e897cd","schema_version":"1.0","event_id":"sha256:1ca9ff08f9ce24dfca8c902a0024c2f3b5899da925939605ac53153bb9e897cd"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/E34VX2TDTBLAHE6FYFDMDKRKI5/bundle.json","state_url":"https://pith.science/pith/E34VX2TDTBLAHE6FYFDMDKRKI5/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/E34VX2TDTBLAHE6FYFDMDKRKI5/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-21T01:35:08Z","links":{"resolver":"https://pith.science/pith/E34VX2TDTBLAHE6FYFDMDKRKI5","bundle":"https://pith.science/pith/E34VX2TDTBLAHE6FYFDMDKRKI5/bundle.json","state":"https://pith.science/pith/E34VX2TDTBLAHE6FYFDMDKRKI5/state.json","well_known_bundle":"https://pith.science/.well-known/pith/E34VX2TDTBLAHE6FYFDMDKRKI5/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2010:E34VX2TDTBLAHE6FYFDMDKRKI5","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"aa2fcb950c80681d6054c3b407c7055b51776a87b06feb61d58f7ff8444b7f1c","cross_cats_sorted":["physics.bio-ph","q-bio.MN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2010-11-19T10:24:36Z","title_canon_sha256":"180da4480053d090301f5370407bec2a7b5cd3e792084cf4543477b512867d2f"},"schema_version":"1.0","source":{"id":"1011.4382","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1011.4382","created_at":"2026-05-18T04:35:14Z"},{"alias_kind":"arxiv_version","alias_value":"1011.4382v1","created_at":"2026-05-18T04:35:14Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1011.4382","created_at":"2026-05-18T04:35:14Z"},{"alias_kind":"pith_short_12","alias_value":"E34VX2TDTBLA","created_at":"2026-05-18T12:26:06Z"},{"alias_kind":"pith_short_16","alias_value":"E34VX2TDTBLAHE6F","created_at":"2026-05-18T12:26:06Z"},{"alias_kind":"pith_short_8","alias_value":"E34VX2TD","created_at":"2026-05-18T12:26:06Z"}],"graph_snapshots":[{"event_id":"sha256:1ca9ff08f9ce24dfca8c902a0024c2f3b5899da925939605ac53153bb9e897cd","target":"graph","created_at":"2026-05-18T04:35:14Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Homologous recombination facilitates the exchange of genetic material between homologous DNA molecules. This crucial process requires detecting a specific homologous DNA sequence within a huge variety of heterologous sequences. The detection is mediated by RecA in E. coli, or members of its superfamily in other organisms. Here we examine how well is the RecA-DNA interaction adjusted to its task. By formulating the DNA recognition process as a signal detection problem, we find the optimal value of binding energy that maximizes the ability to detect homologous sequences. We show that the experim","authors_text":"Tsvi Tlusty, Yonatan Savir","cross_cats":["physics.bio-ph","q-bio.MN"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2010-11-19T10:24:36Z","title":"RecA-mediated homology search as a nearly optimal signal detection system"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1011.4382","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:1396702e44b81ecf8695f4b517ca1a3895410460a2f1d37b944d3389b0bd07c7","target":"record","created_at":"2026-05-18T04:35:14Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"aa2fcb950c80681d6054c3b407c7055b51776a87b06feb61d58f7ff8444b7f1c","cross_cats_sorted":["physics.bio-ph","q-bio.MN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2010-11-19T10:24:36Z","title_canon_sha256":"180da4480053d090301f5370407bec2a7b5cd3e792084cf4543477b512867d2f"},"schema_version":"1.0","source":{"id":"1011.4382","kind":"arxiv","version":1}},"canonical_sha256":"26f95bea6398560393c5c146c1aa2a475c260e7161f41d142be767affa9a0b0e","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"26f95bea6398560393c5c146c1aa2a475c260e7161f41d142be767affa9a0b0e","first_computed_at":"2026-05-18T04:35:14.271458Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T04:35:14.271458Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"Gsyh6NcZVkbshrSR2fAmmu+qgguhhRZv0jKFD2Bv9B9b8C6xd+2K6j85YOZ+yJIlEySECmAR1iGytgYB2UkYBA==","signature_status":"signed_v1","signed_at":"2026-05-18T04:35:14.271941Z","signed_message":"canonical_sha256_bytes"},"source_id":"1011.4382","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:1396702e44b81ecf8695f4b517ca1a3895410460a2f1d37b944d3389b0bd07c7","sha256:1ca9ff08f9ce24dfca8c902a0024c2f3b5899da925939605ac53153bb9e897cd"],"state_sha256":"5faf285be269b75f95059b4058fb10c4315b1dd608a2ecc2d1793df2ca9f9c1c"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"ZWkuvdTOOZ10Km5Y+LfdlvvQzncKce6lQx4v89OgKTFhgZ71uqpDsvQjzUj9Zt65l28blVhS0TcJI9J30WYjCQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-21T01:35:08.947887Z","bundle_sha256":"c23d9f7bed9e06ea9e5f7633dd82481dfafde374bc3bc2043980d6178274606f"}}