{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2010:E3HRBUU73GDHX4QXVHNKCNSWDV","short_pith_number":"pith:E3HRBUU7","schema_version":"1.0","canonical_sha256":"26cf10d29fd9867bf217a9daa136561d5e89464637f0d860b14b0794b10330c6","source":{"kind":"arxiv","id":"1006.5743","version":1},"attestation_state":"computed","paper":{"title":"Enzymatic AND Logic Gates Operated Under Conditions Characteristic of Biomedical Applications","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph","q-bio.MN"],"primary_cat":"cond-mat.soft","authors_text":"Dmitriy Melnikov, Evgeny Katz, Guinevere Strack, Jan Halamek, Jian Zhou, Joseph Wang, Joshua Ray Windmiller, Min-Chieh Chuang, Padmanabhan Santhosh, Vera Bocharova, Vladimir Privman","submitted_at":"2010-06-29T23:50:18Z","abstract_excerpt":"Experimental and theoretical analyses of the lactate dehydrogenase and glutathione reductase based enzymatic AND logic gates in which the enzymes and their substrates serve as logic inputs are performed. These two systems are examples of the novel, previously unexplored, class of biochemical logic gates that illustrate potential biomedical applications of biochemical logic. They are characterized by input concentrations at logic 0 and 1 states corresponding to normal and abnormal physiological conditions. Our analysis shows that the logic gates under investigation have similar noise characteri"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1006.5743","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.soft","submitted_at":"2010-06-29T23:50:18Z","cross_cats_sorted":["physics.bio-ph","q-bio.MN"],"title_canon_sha256":"fe81788009e510ec2f6b64ed3f4f895bbe055426417880ba6ef7b7706ed4c1be","abstract_canon_sha256":"b1cb2d164e32476146e31108cfb958e4fc7fbf390ba50a9d27c3ebd570d21470"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T04:39:38.740303Z","signature_b64":"rsU8uAfrlQddSdlreQX1gE6k2PFfHtn3ivebkuDiUKVaxi3oCYLMhQ2Vte2+EZpyP2+waO68AOIOJKEmexdpCQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"26cf10d29fd9867bf217a9daa136561d5e89464637f0d860b14b0794b10330c6","last_reissued_at":"2026-05-18T04:39:38.739790Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T04:39:38.739790Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Enzymatic AND Logic Gates Operated Under Conditions Characteristic of Biomedical Applications","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph","q-bio.MN"],"primary_cat":"cond-mat.soft","authors_text":"Dmitriy Melnikov, Evgeny Katz, Guinevere Strack, Jan Halamek, Jian Zhou, Joseph Wang, Joshua Ray Windmiller, Min-Chieh Chuang, Padmanabhan Santhosh, Vera Bocharova, Vladimir Privman","submitted_at":"2010-06-29T23:50:18Z","abstract_excerpt":"Experimental and theoretical analyses of the lactate dehydrogenase and glutathione reductase based enzymatic AND logic gates in which the enzymes and their substrates serve as logic inputs are performed. These two systems are examples of the novel, previously unexplored, class of biochemical logic gates that illustrate potential biomedical applications of biochemical logic. They are characterized by input concentrations at logic 0 and 1 states corresponding to normal and abnormal physiological conditions. Our analysis shows that the logic gates under investigation have similar noise characteri"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1006.5743","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1006.5743","created_at":"2026-05-18T04:39:38.739863+00:00"},{"alias_kind":"arxiv_version","alias_value":"1006.5743v1","created_at":"2026-05-18T04:39:38.739863+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1006.5743","created_at":"2026-05-18T04:39:38.739863+00:00"},{"alias_kind":"pith_short_12","alias_value":"E3HRBUU73GDH","created_at":"2026-05-18T12:26:06.534383+00:00"},{"alias_kind":"pith_short_16","alias_value":"E3HRBUU73GDHX4QX","created_at":"2026-05-18T12:26:06.534383+00:00"},{"alias_kind":"pith_short_8","alias_value":"E3HRBUU7","created_at":"2026-05-18T12:26:06.534383+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/E3HRBUU73GDHX4QXVHNKCNSWDV","json":"https://pith.science/pith/E3HRBUU73GDHX4QXVHNKCNSWDV.json","graph_json":"https://pith.science/api/pith-number/E3HRBUU73GDHX4QXVHNKCNSWDV/graph.json","events_json":"https://pith.science/api/pith-number/E3HRBUU73GDHX4QXVHNKCNSWDV/events.json","paper":"https://pith.science/paper/E3HRBUU7"},"agent_actions":{"view_html":"https://pith.science/pith/E3HRBUU73GDHX4QXVHNKCNSWDV","download_json":"https://pith.science/pith/E3HRBUU73GDHX4QXVHNKCNSWDV.json","view_paper":"https://pith.science/paper/E3HRBUU7","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1006.5743&json=true","fetch_graph":"https://pith.science/api/pith-number/E3HRBUU73GDHX4QXVHNKCNSWDV/graph.json","fetch_events":"https://pith.science/api/pith-number/E3HRBUU73GDHX4QXVHNKCNSWDV/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/E3HRBUU73GDHX4QXVHNKCNSWDV/action/timestamp_anchor","attest_storage":"https://pith.science/pith/E3HRBUU73GDHX4QXVHNKCNSWDV/action/storage_attestation","attest_author":"https://pith.science/pith/E3HRBUU73GDHX4QXVHNKCNSWDV/action/author_attestation","sign_citation":"https://pith.science/pith/E3HRBUU73GDHX4QXVHNKCNSWDV/action/citation_signature","submit_replication":"https://pith.science/pith/E3HRBUU73GDHX4QXVHNKCNSWDV/action/replication_record"}},"created_at":"2026-05-18T04:39:38.739863+00:00","updated_at":"2026-05-18T04:39:38.739863+00:00"}