{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2017:EA5AHNSNAJ4AHAWRRV2GJNVWMR","short_pith_number":"pith:EA5AHNSN","canonical_record":{"source":{"id":"1712.04412","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.OT","submitted_at":"2017-12-12T18:10:16Z","cross_cats_sorted":[],"title_canon_sha256":"2cbce3e14b15c51193af7d6d02618e685383c8ee6b8d6eee7674b165f31ec286","abstract_canon_sha256":"b93d5ba5d31f55e8a52dc7c2c4895d79589156319b27ca067c232f3bc1735ff3"},"schema_version":"1.0"},"canonical_sha256":"203a03b64d02780382d18d7464b6b66478467a117f4ce01476e50dba5ac46179","source":{"kind":"arxiv","id":"1712.04412","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1712.04412","created_at":"2026-05-18T00:28:08Z"},{"alias_kind":"arxiv_version","alias_value":"1712.04412v1","created_at":"2026-05-18T00:28:08Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1712.04412","created_at":"2026-05-18T00:28:08Z"},{"alias_kind":"pith_short_12","alias_value":"EA5AHNSNAJ4A","created_at":"2026-05-18T12:31:12Z"},{"alias_kind":"pith_short_16","alias_value":"EA5AHNSNAJ4AHAWR","created_at":"2026-05-18T12:31:12Z"},{"alias_kind":"pith_short_8","alias_value":"EA5AHNSN","created_at":"2026-05-18T12:31:12Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2017:EA5AHNSNAJ4AHAWRRV2GJNVWMR","target":"record","payload":{"canonical_record":{"source":{"id":"1712.04412","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.OT","submitted_at":"2017-12-12T18:10:16Z","cross_cats_sorted":[],"title_canon_sha256":"2cbce3e14b15c51193af7d6d02618e685383c8ee6b8d6eee7674b165f31ec286","abstract_canon_sha256":"b93d5ba5d31f55e8a52dc7c2c4895d79589156319b27ca067c232f3bc1735ff3"},"schema_version":"1.0"},"canonical_sha256":"203a03b64d02780382d18d7464b6b66478467a117f4ce01476e50dba5ac46179","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:28:08.095438Z","signature_b64":"v3wC00AKNgoDiRRJl7PUZ72y6YQf0v9GBklhjN7CLrDUW93PZvDBliEuaLrcZsljp+X1s0LtciM+2E7x4lnrDw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"203a03b64d02780382d18d7464b6b66478467a117f4ce01476e50dba5ac46179","last_reissued_at":"2026-05-18T00:28:08.094910Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:28:08.094910Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1712.04412","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:28:08Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"c6BPtu8GvnCZsphEGN4MeTs8/1OGpfIPSuRpuWbqlHPFss5KHZL9wR2wgmv/cPapGTxDyFK5YsK84BEl8gnnDQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-26T00:29:14.922940Z"},"content_sha256":"53657147c08ecea271b98a4c79e99b5fabde86c8d128af69359925322bacc90b","schema_version":"1.0","event_id":"sha256:53657147c08ecea271b98a4c79e99b5fabde86c8d128af69359925322bacc90b"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2017:EA5AHNSNAJ4AHAWRRV2GJNVWMR","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Missing and spurious interaction in additive, multiplicative and odds ratio models","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.OT","authors_text":"(2) Center of Molecular Immunology, (3) Institute for Protein Research), Biotechnology, Jorge Fernandez-de-Cossio (1), Jorge Fernandez-de-Cossio-Diaz (2), Toshifumi Takao (3), Yasser Perera (1) ((1) Center for Genetic Engineering","submitted_at":"2017-12-12T18:10:16Z","abstract_excerpt":"Additive, multiplicative, and odd ratio neutral models for interactions are for long advocated and controversial in epidemiology. We show here that these commonly advocated models are biased, leading to spurious interactions, and missing true interactions."},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1712.04412","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:28:08Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"qaqdqgIp8ASvuPBJRCTADxtMHqraCT2ViZaGvE7h1VNDgPMJRLRvFqKHFfF7W/98q7A/B4qCJHpg7sSp+eJfDw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-26T00:29:14.923280Z"},"content_sha256":"667f7f34f20a195b8ce4ac3958a2d63b84f71f4c92e3dacafbd49424f98fb030","schema_version":"1.0","event_id":"sha256:667f7f34f20a195b8ce4ac3958a2d63b84f71f4c92e3dacafbd49424f98fb030"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/EA5AHNSNAJ4AHAWRRV2GJNVWMR/bundle.json","state_url":"https://pith.science/pith/EA5AHNSNAJ4AHAWRRV2GJNVWMR/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/EA5AHNSNAJ4AHAWRRV2GJNVWMR/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-26T00:29:14Z","links":{"resolver":"https://pith.science/pith/EA5AHNSNAJ4AHAWRRV2GJNVWMR","bundle":"https://pith.science/pith/EA5AHNSNAJ4AHAWRRV2GJNVWMR/bundle.json","state":"https://pith.science/pith/EA5AHNSNAJ4AHAWRRV2GJNVWMR/state.json","well_known_bundle":"https://pith.science/.well-known/pith/EA5AHNSNAJ4AHAWRRV2GJNVWMR/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2017:EA5AHNSNAJ4AHAWRRV2GJNVWMR","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"b93d5ba5d31f55e8a52dc7c2c4895d79589156319b27ca067c232f3bc1735ff3","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.OT","submitted_at":"2017-12-12T18:10:16Z","title_canon_sha256":"2cbce3e14b15c51193af7d6d02618e685383c8ee6b8d6eee7674b165f31ec286"},"schema_version":"1.0","source":{"id":"1712.04412","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1712.04412","created_at":"2026-05-18T00:28:08Z"},{"alias_kind":"arxiv_version","alias_value":"1712.04412v1","created_at":"2026-05-18T00:28:08Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1712.04412","created_at":"2026-05-18T00:28:08Z"},{"alias_kind":"pith_short_12","alias_value":"EA5AHNSNAJ4A","created_at":"2026-05-18T12:31:12Z"},{"alias_kind":"pith_short_16","alias_value":"EA5AHNSNAJ4AHAWR","created_at":"2026-05-18T12:31:12Z"},{"alias_kind":"pith_short_8","alias_value":"EA5AHNSN","created_at":"2026-05-18T12:31:12Z"}],"graph_snapshots":[{"event_id":"sha256:667f7f34f20a195b8ce4ac3958a2d63b84f71f4c92e3dacafbd49424f98fb030","target":"graph","created_at":"2026-05-18T00:28:08Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Additive, multiplicative, and odd ratio neutral models for interactions are for long advocated and controversial in epidemiology. We show here that these commonly advocated models are biased, leading to spurious interactions, and missing true interactions.","authors_text":"(2) Center of Molecular Immunology, (3) Institute for Protein Research), Biotechnology, Jorge Fernandez-de-Cossio (1), Jorge Fernandez-de-Cossio-Diaz (2), Toshifumi Takao (3), Yasser Perera (1) ((1) Center for Genetic Engineering","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.OT","submitted_at":"2017-12-12T18:10:16Z","title":"Missing and spurious interaction in additive, multiplicative and odds ratio models"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1712.04412","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:53657147c08ecea271b98a4c79e99b5fabde86c8d128af69359925322bacc90b","target":"record","created_at":"2026-05-18T00:28:08Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"b93d5ba5d31f55e8a52dc7c2c4895d79589156319b27ca067c232f3bc1735ff3","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.OT","submitted_at":"2017-12-12T18:10:16Z","title_canon_sha256":"2cbce3e14b15c51193af7d6d02618e685383c8ee6b8d6eee7674b165f31ec286"},"schema_version":"1.0","source":{"id":"1712.04412","kind":"arxiv","version":1}},"canonical_sha256":"203a03b64d02780382d18d7464b6b66478467a117f4ce01476e50dba5ac46179","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"203a03b64d02780382d18d7464b6b66478467a117f4ce01476e50dba5ac46179","first_computed_at":"2026-05-18T00:28:08.094910Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:28:08.094910Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"v3wC00AKNgoDiRRJl7PUZ72y6YQf0v9GBklhjN7CLrDUW93PZvDBliEuaLrcZsljp+X1s0LtciM+2E7x4lnrDw==","signature_status":"signed_v1","signed_at":"2026-05-18T00:28:08.095438Z","signed_message":"canonical_sha256_bytes"},"source_id":"1712.04412","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:53657147c08ecea271b98a4c79e99b5fabde86c8d128af69359925322bacc90b","sha256:667f7f34f20a195b8ce4ac3958a2d63b84f71f4c92e3dacafbd49424f98fb030"],"state_sha256":"e2005304d386ed9c82f1b3172d296d5f3a1066d7c5af2e3a7ad27f772a9b903a"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"zFYPtFw4TVHHXJanR8blLKqRWkuzNtrXH4lTp98kXWXAW6eDyvgR+11HcP4Dk1Q+QXQYHKgrYFLxjIHrAGDDBw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-26T00:29:14.925172Z","bundle_sha256":"d921a64fc858f5769a9126206452e7465a9b229cae594e5e206f84f87f11dcd0"}}