{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2004:EDBHZFUN3CR2KOEDNVEHBSH54M","short_pith_number":"pith:EDBHZFUN","canonical_record":{"source":{"id":"q-bio/0401012","kind":"arxiv","version":1},"metadata":{"license":"","primary_cat":"q-bio.BM","submitted_at":"2004-01-08T17:50:55Z","cross_cats_sorted":[],"title_canon_sha256":"8a54fbb29eefb24109484b8e7e6bfc5b5b60792cc21a92812e5e2147d0ee05d0","abstract_canon_sha256":"ed770bde09b859478c1de4bde79ba8bac54072c9f65561c35ef7d1b990cfe0c9"},"schema_version":"1.0"},"canonical_sha256":"20c27c968dd8a3a538836d4870c8fde32d9688418e0447460143ad231c53eada","source":{"kind":"arxiv","id":"q-bio/0401012","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"q-bio/0401012","created_at":"2026-07-04T16:50:08Z"},{"alias_kind":"arxiv_version","alias_value":"q-bio/0401012v1","created_at":"2026-07-04T16:50:08Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.q-bio/0401012","created_at":"2026-07-04T16:50:08Z"},{"alias_kind":"pith_short_12","alias_value":"EDBHZFUN3CR2","created_at":"2026-07-04T16:50:08Z"},{"alias_kind":"pith_short_16","alias_value":"EDBHZFUN3CR2KOED","created_at":"2026-07-04T16:50:08Z"},{"alias_kind":"pith_short_8","alias_value":"EDBHZFUN","created_at":"2026-07-04T16:50:08Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2004:EDBHZFUN3CR2KOEDNVEHBSH54M","target":"record","payload":{"canonical_record":{"source":{"id":"q-bio/0401012","kind":"arxiv","version":1},"metadata":{"license":"","primary_cat":"q-bio.BM","submitted_at":"2004-01-08T17:50:55Z","cross_cats_sorted":[],"title_canon_sha256":"8a54fbb29eefb24109484b8e7e6bfc5b5b60792cc21a92812e5e2147d0ee05d0","abstract_canon_sha256":"ed770bde09b859478c1de4bde79ba8bac54072c9f65561c35ef7d1b990cfe0c9"},"schema_version":"1.0"},"canonical_sha256":"20c27c968dd8a3a538836d4870c8fde32d9688418e0447460143ad231c53eada","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-04T16:50:08.066251Z","signature_b64":"VIfNstte+2yHWfpPCxBOzkBYlv3jfc659D+004ommhJFsV50Tegps7RLSoeEY64ci2p6idVvq7kFo8H2qgFDAA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"20c27c968dd8a3a538836d4870c8fde32d9688418e0447460143ad231c53eada","last_reissued_at":"2026-07-04T16:50:08.065903Z","signature_status":"signed_v1","first_computed_at":"2026-07-04T16:50:08.065903Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"q-bio/0401012","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-04T16:50:08Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"mEvot9gngZ9eR5fp0HJhtPq01QVW0q1CKQuHj4dcdrlQ2i1aFMaUiJqmO/nuafVYePzeCwklCqE+V1uPY0m1Dw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-04T18:07:15.191613Z"},"content_sha256":"885a111650a4b09e564b3e74b3bb1e42616b2e63d3af827795bc1d4e8e7d9ee3","schema_version":"1.0","event_id":"sha256:885a111650a4b09e564b3e74b3bb1e42616b2e63d3af827795bc1d4e8e7d9ee3"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2004:EDBHZFUN3CR2KOEDNVEHBSH54M","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Temperature Dependent Conformational Transitions and Hydrogen Bond Dynamics of the Elastin-Like Octapeptide GVG(VPGVG): a Molecular Dynamics Study","license":"","headline":"","cross_cats":[],"primary_cat":"q-bio.BM","authors_text":"Axel Kohlmeyer, Dominik Marx, Eduard Schreiner, Roger Rousseau","submitted_at":"2004-01-08T17:50:55Z","abstract_excerpt":"A joint experimental / theoretical investigation of the elastin-like octapeptide GVG(VPGVG) was carried out. In this paper a comprehensive molecular dynamics study of the temperature dependent folding and unfolding of the octapeptide is presented. The current study, as well as its experimental counterpart find that this peptide undergoes an \"inverse temperature transition\", ITT, leading to a folding at about 310-330 K. In addition, an unfolding transition is identified at unusually high temperatures approaching the boiling point of water. Due to the small size of the system two broad temperatu"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"q-bio/0401012","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/q-bio/0401012/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-04T16:50:08Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"QSEGnQlB8mrwmC8MRboHPeLz3GUKnaW1uQ/6F0SI+E+JYe8FZys0tjsIoSdTszPIkZCu0yubPRvLEMcF9OFfBg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-04T18:07:15.192211Z"},"content_sha256":"779354e8d3eb9bea147a76fe9c61da4fcb6e3bcd206ae707498a6834bd040b46","schema_version":"1.0","event_id":"sha256:779354e8d3eb9bea147a76fe9c61da4fcb6e3bcd206ae707498a6834bd040b46"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/EDBHZFUN3CR2KOEDNVEHBSH54M/bundle.json","state_url":"https://pith.science/pith/EDBHZFUN3CR2KOEDNVEHBSH54M/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/EDBHZFUN3CR2KOEDNVEHBSH54M/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-04T18:07:15Z","links":{"resolver":"https://pith.science/pith/EDBHZFUN3CR2KOEDNVEHBSH54M","bundle":"https://pith.science/pith/EDBHZFUN3CR2KOEDNVEHBSH54M/bundle.json","state":"https://pith.science/pith/EDBHZFUN3CR2KOEDNVEHBSH54M/state.json","well_known_bundle":"https://pith.science/.well-known/pith/EDBHZFUN3CR2KOEDNVEHBSH54M/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2004:EDBHZFUN3CR2KOEDNVEHBSH54M","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"ed770bde09b859478c1de4bde79ba8bac54072c9f65561c35ef7d1b990cfe0c9","cross_cats_sorted":[],"license":"","primary_cat":"q-bio.BM","submitted_at":"2004-01-08T17:50:55Z","title_canon_sha256":"8a54fbb29eefb24109484b8e7e6bfc5b5b60792cc21a92812e5e2147d0ee05d0"},"schema_version":"1.0","source":{"id":"q-bio/0401012","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"q-bio/0401012","created_at":"2026-07-04T16:50:08Z"},{"alias_kind":"arxiv_version","alias_value":"q-bio/0401012v1","created_at":"2026-07-04T16:50:08Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.q-bio/0401012","created_at":"2026-07-04T16:50:08Z"},{"alias_kind":"pith_short_12","alias_value":"EDBHZFUN3CR2","created_at":"2026-07-04T16:50:08Z"},{"alias_kind":"pith_short_16","alias_value":"EDBHZFUN3CR2KOED","created_at":"2026-07-04T16:50:08Z"},{"alias_kind":"pith_short_8","alias_value":"EDBHZFUN","created_at":"2026-07-04T16:50:08Z"}],"graph_snapshots":[{"event_id":"sha256:779354e8d3eb9bea147a76fe9c61da4fcb6e3bcd206ae707498a6834bd040b46","target":"graph","created_at":"2026-07-04T16:50:08Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/q-bio/0401012/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"A joint experimental / theoretical investigation of the elastin-like octapeptide GVG(VPGVG) was carried out. In this paper a comprehensive molecular dynamics study of the temperature dependent folding and unfolding of the octapeptide is presented. The current study, as well as its experimental counterpart find that this peptide undergoes an \"inverse temperature transition\", ITT, leading to a folding at about 310-330 K. In addition, an unfolding transition is identified at unusually high temperatures approaching the boiling point of water. Due to the small size of the system two broad temperatu","authors_text":"Axel Kohlmeyer, Dominik Marx, Eduard Schreiner, Roger Rousseau","cross_cats":[],"headline":"","license":"","primary_cat":"q-bio.BM","submitted_at":"2004-01-08T17:50:55Z","title":"Temperature Dependent Conformational Transitions and Hydrogen Bond Dynamics of the Elastin-Like Octapeptide GVG(VPGVG): a Molecular Dynamics Study"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"q-bio/0401012","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:885a111650a4b09e564b3e74b3bb1e42616b2e63d3af827795bc1d4e8e7d9ee3","target":"record","created_at":"2026-07-04T16:50:08Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"ed770bde09b859478c1de4bde79ba8bac54072c9f65561c35ef7d1b990cfe0c9","cross_cats_sorted":[],"license":"","primary_cat":"q-bio.BM","submitted_at":"2004-01-08T17:50:55Z","title_canon_sha256":"8a54fbb29eefb24109484b8e7e6bfc5b5b60792cc21a92812e5e2147d0ee05d0"},"schema_version":"1.0","source":{"id":"q-bio/0401012","kind":"arxiv","version":1}},"canonical_sha256":"20c27c968dd8a3a538836d4870c8fde32d9688418e0447460143ad231c53eada","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"20c27c968dd8a3a538836d4870c8fde32d9688418e0447460143ad231c53eada","first_computed_at":"2026-07-04T16:50:08.065903Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-04T16:50:08.065903Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"VIfNstte+2yHWfpPCxBOzkBYlv3jfc659D+004ommhJFsV50Tegps7RLSoeEY64ci2p6idVvq7kFo8H2qgFDAA==","signature_status":"signed_v1","signed_at":"2026-07-04T16:50:08.066251Z","signed_message":"canonical_sha256_bytes"},"source_id":"q-bio/0401012","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:885a111650a4b09e564b3e74b3bb1e42616b2e63d3af827795bc1d4e8e7d9ee3","sha256:779354e8d3eb9bea147a76fe9c61da4fcb6e3bcd206ae707498a6834bd040b46"],"state_sha256":"b141fd41cb743a8baa70431c43bbed2da2064abc2c54c6f66f6871a611ac2581"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"fOqPq3Ma9VQ1JKnbH4EdYvM4oxPF/Yk5Ok8isX3/a23qLiTcTAR11PApyB54gn4XnSjzDxoozd1XeBeY+ashCg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-04T18:07:15.196726Z","bundle_sha256":"c0356cb7cd97d77b79db75a458b5837d047c5f86d0f8421d45756f16e94304f1"}}