{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2013:EFXIZYSISSTG3YCKKG5VRNOH5B","short_pith_number":"pith:EFXIZYSI","schema_version":"1.0","canonical_sha256":"216e8ce24894a66de04a51bb58b5c7e842805026f388d5ef1cdd2bfb3c87898d","source":{"kind":"arxiv","id":"1306.5524","version":1},"attestation_state":"computed","paper":{"title":"Soft Null Hypotheses: A Case Study of Image Enhancement Detection in Brain Lesions","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"stat.AP","authors_text":"Ciprian M. Crainiceanu, Daniel S. Reich, Han Liu, Haochang Shou, Russell T. Shinohara","submitted_at":"2013-06-24T07:26:23Z","abstract_excerpt":"This work is motivated by a study of a population of multiple sclerosis (MS) patients using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to identify active brain lesions. At each visit, a contrast agent is administered intravenously to a subject and a series of images is acquired to reveal the location and activity of MS lesions within the brain. Our goal is to identify and quantify lesion enhancement location at the subject level and lesion enhancement patterns at the population level. With this example, we aim to address the difficult problem of transforming a qualitative s"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1306.5524","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.AP","submitted_at":"2013-06-24T07:26:23Z","cross_cats_sorted":[],"title_canon_sha256":"fb000faacae23f632582fae321707c0ddaab6e407f68730913b0a8798bdd33e0","abstract_canon_sha256":"9ae901d175535dc30febcf3fad18dbdf507e4c81ed77a632c9e6661406ae1578"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T03:20:07.742845Z","signature_b64":"8XhBgE37w4jkY3yGfP68aYO0WzZ91rYHsj0kiDA3q2b3VvYq/IM2umZARWuG0H5IMluvN8Gue6Pk8+AuUuwsBA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"216e8ce24894a66de04a51bb58b5c7e842805026f388d5ef1cdd2bfb3c87898d","last_reissued_at":"2026-05-18T03:20:07.742198Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T03:20:07.742198Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Soft Null Hypotheses: A Case Study of Image Enhancement Detection in Brain Lesions","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"stat.AP","authors_text":"Ciprian M. Crainiceanu, Daniel S. Reich, Han Liu, Haochang Shou, Russell T. Shinohara","submitted_at":"2013-06-24T07:26:23Z","abstract_excerpt":"This work is motivated by a study of a population of multiple sclerosis (MS) patients using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to identify active brain lesions. At each visit, a contrast agent is administered intravenously to a subject and a series of images is acquired to reveal the location and activity of MS lesions within the brain. Our goal is to identify and quantify lesion enhancement location at the subject level and lesion enhancement patterns at the population level. With this example, we aim to address the difficult problem of transforming a qualitative s"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1306.5524","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1306.5524","created_at":"2026-05-18T03:20:07.742308+00:00"},{"alias_kind":"arxiv_version","alias_value":"1306.5524v1","created_at":"2026-05-18T03:20:07.742308+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1306.5524","created_at":"2026-05-18T03:20:07.742308+00:00"},{"alias_kind":"pith_short_12","alias_value":"EFXIZYSISSTG","created_at":"2026-05-18T12:27:43.054852+00:00"},{"alias_kind":"pith_short_16","alias_value":"EFXIZYSISSTG3YCK","created_at":"2026-05-18T12:27:43.054852+00:00"},{"alias_kind":"pith_short_8","alias_value":"EFXIZYSI","created_at":"2026-05-18T12:27:43.054852+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/EFXIZYSISSTG3YCKKG5VRNOH5B","json":"https://pith.science/pith/EFXIZYSISSTG3YCKKG5VRNOH5B.json","graph_json":"https://pith.science/api/pith-number/EFXIZYSISSTG3YCKKG5VRNOH5B/graph.json","events_json":"https://pith.science/api/pith-number/EFXIZYSISSTG3YCKKG5VRNOH5B/events.json","paper":"https://pith.science/paper/EFXIZYSI"},"agent_actions":{"view_html":"https://pith.science/pith/EFXIZYSISSTG3YCKKG5VRNOH5B","download_json":"https://pith.science/pith/EFXIZYSISSTG3YCKKG5VRNOH5B.json","view_paper":"https://pith.science/paper/EFXIZYSI","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1306.5524&json=true","fetch_graph":"https://pith.science/api/pith-number/EFXIZYSISSTG3YCKKG5VRNOH5B/graph.json","fetch_events":"https://pith.science/api/pith-number/EFXIZYSISSTG3YCKKG5VRNOH5B/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/EFXIZYSISSTG3YCKKG5VRNOH5B/action/timestamp_anchor","attest_storage":"https://pith.science/pith/EFXIZYSISSTG3YCKKG5VRNOH5B/action/storage_attestation","attest_author":"https://pith.science/pith/EFXIZYSISSTG3YCKKG5VRNOH5B/action/author_attestation","sign_citation":"https://pith.science/pith/EFXIZYSISSTG3YCKKG5VRNOH5B/action/citation_signature","submit_replication":"https://pith.science/pith/EFXIZYSISSTG3YCKKG5VRNOH5B/action/replication_record"}},"created_at":"2026-05-18T03:20:07.742308+00:00","updated_at":"2026-05-18T03:20:07.742308+00:00"}