{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2017:EKAL2YT5UNR32SBUMMUHDLRUR6","short_pith_number":"pith:EKAL2YT5","canonical_record":{"source":{"id":"1709.06045","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.stat-mech","submitted_at":"2017-09-18T17:03:47Z","cross_cats_sorted":["physics.chem-ph","q-bio.MN"],"title_canon_sha256":"b71f1c7276bd981a7ec06061aee615402a660b16329f70dadb0f9fd1232d9d85","abstract_canon_sha256":"f26d4e3fcb451217e7e897874279e23fdaa9a653c5a5c1c387ae513f2230787c"},"schema_version":"1.0"},"canonical_sha256":"2280bd627da363bd4834632871ae348f8ca2aaf27d1dc2539a684d7ac2800eb6","source":{"kind":"arxiv","id":"1709.06045","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1709.06045","created_at":"2026-05-18T00:17:27Z"},{"alias_kind":"arxiv_version","alias_value":"1709.06045v2","created_at":"2026-05-18T00:17:27Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1709.06045","created_at":"2026-05-18T00:17:27Z"},{"alias_kind":"pith_short_12","alias_value":"EKAL2YT5UNR3","created_at":"2026-05-18T12:31:12Z"},{"alias_kind":"pith_short_16","alias_value":"EKAL2YT5UNR32SBU","created_at":"2026-05-18T12:31:12Z"},{"alias_kind":"pith_short_8","alias_value":"EKAL2YT5","created_at":"2026-05-18T12:31:12Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2017:EKAL2YT5UNR32SBUMMUHDLRUR6","target":"record","payload":{"canonical_record":{"source":{"id":"1709.06045","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.stat-mech","submitted_at":"2017-09-18T17:03:47Z","cross_cats_sorted":["physics.chem-ph","q-bio.MN"],"title_canon_sha256":"b71f1c7276bd981a7ec06061aee615402a660b16329f70dadb0f9fd1232d9d85","abstract_canon_sha256":"f26d4e3fcb451217e7e897874279e23fdaa9a653c5a5c1c387ae513f2230787c"},"schema_version":"1.0"},"canonical_sha256":"2280bd627da363bd4834632871ae348f8ca2aaf27d1dc2539a684d7ac2800eb6","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:17:27.153529Z","signature_b64":"eHXslLFm3qnmukuoVgIQWGoMgu7DZDDwmPgChB2F5ExnPzl4r9B8sJsR+tiSGeXGutXbtYxQXS+OWdU/M7HFAg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"2280bd627da363bd4834632871ae348f8ca2aaf27d1dc2539a684d7ac2800eb6","last_reissued_at":"2026-05-18T00:17:27.153064Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:17:27.153064Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1709.06045","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:17:27Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"UIOKFMbZcbhdITQU7CDb84EaUnsQnVVv6PXfkJXqTkUr/EWsbyHfbwgHBmo0NzAPtGq/0o3wEGoPqZ+zg4VkCw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-04T19:20:40.947673Z"},"content_sha256":"e923a821e759e0f343d8a03c9ea4ac864defe97e4e0b218201465084b08bc121","schema_version":"1.0","event_id":"sha256:e923a821e759e0f343d8a03c9ea4ac864defe97e4e0b218201465084b08bc121"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2017:EKAL2YT5UNR32SBUMMUHDLRUR6","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Thermodynamically Consistent Coarse Graining of Biocatalysts beyond Michaelis--Menten","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.chem-ph","q-bio.MN"],"primary_cat":"cond-mat.stat-mech","authors_text":"Artur Wachtel, Massimiliano Esposito, Riccardo Rao","submitted_at":"2017-09-18T17:03:47Z","abstract_excerpt":"Starting from the detailed catalytic mechanism of a biocatalyst we provide a coarse-graining procedure which, by construction, is thermodynamically consistent. This procedure provides stoichiometries, reaction fluxes (rate laws), and reaction forces (Gibbs energies of reaction) for the coarse-grained level. It can treat active transporters and molecular machines, and thus extends the applicability of ideas that originated in enzyme kinetics. Our results lay the foundations for systematic studies of the thermodynamics of large-scale biochemical reaction networks. Moreover, we identify the condi"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1709.06045","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:17:27Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"PRpx0uw0BWoeBzkQlxuYD5XZFNP33HwQwgyj6Tti0P7yp3QSdI9/oo7JmYcUm1flKak3nSeuzcUAi5p2hjSWDw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-04T19:20:40.948013Z"},"content_sha256":"696c571452a1a3034fbb6549eb76fc7df64f19b58a29ae1151e57d474ef19075","schema_version":"1.0","event_id":"sha256:696c571452a1a3034fbb6549eb76fc7df64f19b58a29ae1151e57d474ef19075"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/EKAL2YT5UNR32SBUMMUHDLRUR6/bundle.json","state_url":"https://pith.science/pith/EKAL2YT5UNR32SBUMMUHDLRUR6/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/EKAL2YT5UNR32SBUMMUHDLRUR6/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-04T19:20:40Z","links":{"resolver":"https://pith.science/pith/EKAL2YT5UNR32SBUMMUHDLRUR6","bundle":"https://pith.science/pith/EKAL2YT5UNR32SBUMMUHDLRUR6/bundle.json","state":"https://pith.science/pith/EKAL2YT5UNR32SBUMMUHDLRUR6/state.json","well_known_bundle":"https://pith.science/.well-known/pith/EKAL2YT5UNR32SBUMMUHDLRUR6/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2017:EKAL2YT5UNR32SBUMMUHDLRUR6","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"f26d4e3fcb451217e7e897874279e23fdaa9a653c5a5c1c387ae513f2230787c","cross_cats_sorted":["physics.chem-ph","q-bio.MN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.stat-mech","submitted_at":"2017-09-18T17:03:47Z","title_canon_sha256":"b71f1c7276bd981a7ec06061aee615402a660b16329f70dadb0f9fd1232d9d85"},"schema_version":"1.0","source":{"id":"1709.06045","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1709.06045","created_at":"2026-05-18T00:17:27Z"},{"alias_kind":"arxiv_version","alias_value":"1709.06045v2","created_at":"2026-05-18T00:17:27Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1709.06045","created_at":"2026-05-18T00:17:27Z"},{"alias_kind":"pith_short_12","alias_value":"EKAL2YT5UNR3","created_at":"2026-05-18T12:31:12Z"},{"alias_kind":"pith_short_16","alias_value":"EKAL2YT5UNR32SBU","created_at":"2026-05-18T12:31:12Z"},{"alias_kind":"pith_short_8","alias_value":"EKAL2YT5","created_at":"2026-05-18T12:31:12Z"}],"graph_snapshots":[{"event_id":"sha256:696c571452a1a3034fbb6549eb76fc7df64f19b58a29ae1151e57d474ef19075","target":"graph","created_at":"2026-05-18T00:17:27Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Starting from the detailed catalytic mechanism of a biocatalyst we provide a coarse-graining procedure which, by construction, is thermodynamically consistent. This procedure provides stoichiometries, reaction fluxes (rate laws), and reaction forces (Gibbs energies of reaction) for the coarse-grained level. It can treat active transporters and molecular machines, and thus extends the applicability of ideas that originated in enzyme kinetics. Our results lay the foundations for systematic studies of the thermodynamics of large-scale biochemical reaction networks. Moreover, we identify the condi","authors_text":"Artur Wachtel, Massimiliano Esposito, Riccardo Rao","cross_cats":["physics.chem-ph","q-bio.MN"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.stat-mech","submitted_at":"2017-09-18T17:03:47Z","title":"Thermodynamically Consistent Coarse Graining of Biocatalysts beyond Michaelis--Menten"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1709.06045","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:e923a821e759e0f343d8a03c9ea4ac864defe97e4e0b218201465084b08bc121","target":"record","created_at":"2026-05-18T00:17:27Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"f26d4e3fcb451217e7e897874279e23fdaa9a653c5a5c1c387ae513f2230787c","cross_cats_sorted":["physics.chem-ph","q-bio.MN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.stat-mech","submitted_at":"2017-09-18T17:03:47Z","title_canon_sha256":"b71f1c7276bd981a7ec06061aee615402a660b16329f70dadb0f9fd1232d9d85"},"schema_version":"1.0","source":{"id":"1709.06045","kind":"arxiv","version":2}},"canonical_sha256":"2280bd627da363bd4834632871ae348f8ca2aaf27d1dc2539a684d7ac2800eb6","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"2280bd627da363bd4834632871ae348f8ca2aaf27d1dc2539a684d7ac2800eb6","first_computed_at":"2026-05-18T00:17:27.153064Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:17:27.153064Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"eHXslLFm3qnmukuoVgIQWGoMgu7DZDDwmPgChB2F5ExnPzl4r9B8sJsR+tiSGeXGutXbtYxQXS+OWdU/M7HFAg==","signature_status":"signed_v1","signed_at":"2026-05-18T00:17:27.153529Z","signed_message":"canonical_sha256_bytes"},"source_id":"1709.06045","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:e923a821e759e0f343d8a03c9ea4ac864defe97e4e0b218201465084b08bc121","sha256:696c571452a1a3034fbb6549eb76fc7df64f19b58a29ae1151e57d474ef19075"],"state_sha256":"0ad8369bc6d6efd08154b1cad4f36a39190794c1e06354a1f45973954ac642de"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"jldDaQFvRwuhu5kcKvUhnTKXhqGudVSDlVIAcuaAhnOU4L2VNkcFMnu1y0bngCuNrdCjbMwjbl1aRMXxLHyzCw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-04T19:20:40.949922Z","bundle_sha256":"039ca73e36732c314e461df09e1bd65e8bcdef56e5c0b34b3daed6376d103de7"}}