{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2011:EKJ2MVE223FQNJLBUC7X4VFYC7","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"579b33ad2a93fb00f0c3d35c7e38bbf1a15076ae89e8d2e420d6a0bf082f9cf2","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2011-12-12T14:38:44Z","title_canon_sha256":"ea9c81bb938a08e2ef6efecd5de5d9363d63a1a1dc957b827ba3b30eee80cd42"},"schema_version":"1.0","source":{"id":"1112.2563","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1112.2563","created_at":"2026-05-18T04:06:34Z"},{"alias_kind":"arxiv_version","alias_value":"1112.2563v1","created_at":"2026-05-18T04:06:34Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1112.2563","created_at":"2026-05-18T04:06:34Z"},{"alias_kind":"pith_short_12","alias_value":"EKJ2MVE223FQ","created_at":"2026-05-18T12:26:28Z"},{"alias_kind":"pith_short_16","alias_value":"EKJ2MVE223FQNJLB","created_at":"2026-05-18T12:26:28Z"},{"alias_kind":"pith_short_8","alias_value":"EKJ2MVE2","created_at":"2026-05-18T12:26:28Z"}],"graph_snapshots":[{"event_id":"sha256:7d903de07641837969520a592360250d2ccb0160c4db0ccc28c71968e9d05985","target":"graph","created_at":"2026-05-18T04:06:34Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"This work concerns the identification of the allelic sequences of the DQB1 gene of the human leukocyte antigen system conferring susceptibility to the development of insulin-dependent diabetes mellitus (IDDM) in DNA samples with no need of PCR amplification. Our method is based on the time-resolved analysis of a F\\\"orster energy-transfer mechanism that occurs in a dual-labeled fluorescent probe specific for the base sequence of the allelic variant of interest. Such an oligonucleotide probe is labeled, at the two ends, by a pair of chromophores that operate as donor and acceptor in a F\\\"orster ","authors_text":"Alessandra Andreoni, Giovanna Tosi, Luca Nardo, Maria Bondani, Roberto S. Accolla","cross_cats":["physics.bio-ph"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2011-12-12T14:38:44Z","title":"Polymorphic gene conferring susceptibility to insulin-dependent diabetes mellitus typed by ps-resolved FRET on nonamplified genomic DNA"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1112.2563","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:c2a3b513343343fa5cc17521ed3c3c65a50b6d4c1c1346c03b5be23553ddc66b","target":"record","created_at":"2026-05-18T04:06:34Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"579b33ad2a93fb00f0c3d35c7e38bbf1a15076ae89e8d2e420d6a0bf082f9cf2","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2011-12-12T14:38:44Z","title_canon_sha256":"ea9c81bb938a08e2ef6efecd5de5d9363d63a1a1dc957b827ba3b30eee80cd42"},"schema_version":"1.0","source":{"id":"1112.2563","kind":"arxiv","version":1}},"canonical_sha256":"2293a6549ad6cb06a561a0bf7e54b817c08d675ba030a89995340d883bd7a9b7","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"2293a6549ad6cb06a561a0bf7e54b817c08d675ba030a89995340d883bd7a9b7","first_computed_at":"2026-05-18T04:06:34.005345Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T04:06:34.005345Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"wls7RG79226f+ywTHhYgGJLqa0//m6bDYGEQ7S5paXjsOCTekgQIeTYhbCbrexo2jaDIyK1y+jZ/HE5YWXjbCw==","signature_status":"signed_v1","signed_at":"2026-05-18T04:06:34.006114Z","signed_message":"canonical_sha256_bytes"},"source_id":"1112.2563","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:c2a3b513343343fa5cc17521ed3c3c65a50b6d4c1c1346c03b5be23553ddc66b","sha256:7d903de07641837969520a592360250d2ccb0160c4db0ccc28c71968e9d05985"],"state_sha256":"26f6062e474c05f40d09918d9f7bae18bbd73f0659838945008d7e777d579701"}