{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2026:EM2E4L35TQJZZ7PSTC4UUMA3G3","merge_version":"pith-open-graph-merge-v1","event_count":13,"valid_event_count":13,"invalid_event_count":0,"equivocation_count":1,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"40828dad0a0271c0e6bb369c461a3c6e753a4e06276ad3caf5b0d1bd8ee61cd2","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2026-05-19T17:19:38Z","title_canon_sha256":"76f2db20ce0f24eb4cb302248bd0731fc772e93f9c29fc968b25670f2cc885ad"},"schema_version":"1.0","source":{"id":"2605.20135","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2605.20135","created_at":"2026-05-20T02:06:03Z"},{"alias_kind":"arxiv_version","alias_value":"2605.20135v1","created_at":"2026-05-20T02:06:03Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2605.20135","created_at":"2026-05-20T02:06:03Z"},{"alias_kind":"pith_short_12","alias_value":"EM2E4L35TQJZ","created_at":"2026-05-20T02:06:03Z"},{"alias_kind":"pith_short_16","alias_value":"EM2E4L35TQJZZ7PS","created_at":"2026-05-20T02:06:03Z"},{"alias_kind":"pith_short_8","alias_value":"EM2E4L35","created_at":"2026-05-20T02:06:03Z"}],"graph_snapshots":[{"event_id":"sha256:1ed8e1480881db62e0df8abd8824d5d051240fe7f3c8ea5526d78835f84b515c","target":"graph","created_at":"2026-05-20T02:06:03Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2605.20135/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"In clinical studies, persistence, which measures the duration of time a patient continues to take a prescribed medication without discontinuation, is increasingly recognized as a critical indicator of adherence to medication. Adherence encompasses not only whether a patient takes their medication as prescribed but also the consistency and duration with which they do so. Among the various metrics used to evaluate adherence, persistence stands out as a particularly robust measure because it provides a temporal dimension, reflecting the sustained commitment of patients to their therapeutic regime","authors_text":"Midhu N.N, Prasanth V.P., Sankaran P.G.","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2026-05-19T17:19:38Z","title":"Quantile-Based Effectiveness Persistence Function: A Tail-Focused Metric with Theory, Estimation, and Application to Biosimilar Evaluation"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2605.20135","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:861da2e13905305ccbb09ae83241ffadf8bad72690d5c201770d548839ecc8bf","target":"record","created_at":"2026-05-20T02:06:03Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"40828dad0a0271c0e6bb369c461a3c6e753a4e06276ad3caf5b0d1bd8ee61cd2","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2026-05-19T17:19:38Z","title_canon_sha256":"76f2db20ce0f24eb4cb302248bd0731fc772e93f9c29fc968b25670f2cc885ad"},"schema_version":"1.0","source":{"id":"2605.20135","kind":"arxiv","version":1}},"canonical_sha256":"23344e2f7d9c139cfdf298b94a301b36f92a2e4d56bbdd6fba2941352a192565","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"23344e2f7d9c139cfdf298b94a301b36f92a2e4d56bbdd6fba2941352a192565","first_computed_at":"2026-05-20T02:06:03.642687Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-20T02:06:03.642687Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"jjPfU0CdcL98wQgW7t7L0fVHg3FGk1tGW8J4Gln9DIAMVbE7yXb0zfdhdXJMIzaXyAgwBXce7cPlEmIIOCwfBw==","signature_status":"signed_v1","signed_at":"2026-05-20T02:06:03.643529Z","signed_message":"canonical_sha256_bytes"},"source_id":"2605.20135","source_kind":"arxiv","source_version":1}}},"equivocations":[{"signer_id":"pith.science","event_type":"integrity_finding","target":"integrity","event_ids":["sha256:172c197e712698bfa02a0d21e54f5ed6a855b63b6e1aeb0d7520235590b360c0","sha256:623d6dbd908f837a3de06e1bdc1bb8e849ba165ed1ef8e79fd5dc4f0ceac931b","sha256:7084e2324fd3047e79ff82ff98ddde7dec4e7bdf3107fa131b34d9cca4a998a4","sha256:7a744b6b9787ca4d26cca881352fd16da5567a7545aa788fb289fa53deda9221","sha256:7e9f8105dc80f7f1e0249b93145d9d3722d8c2c82184881db311ad62f5acbeed","sha256:87e420a2b863d5e4b57e5c113ec32d0143cf2817f5e588261838deaad1dd0c8f","sha256:a4f0291eb8c560193786433609b4c1c5a35581484d518aaab198732ee8c90486","sha256:d8d8e404d395d7dceedb80833127fc7a8d6ff3f1b15803f3db91fcaecde46329","sha256:da8d94b0e70e482b668b572fdfddd905a04a0a3c968f5c421afa38f0e58b48d3","sha256:e02840701e06457e94cadf55dd0363fb521c277689e70dd1128ea136197d7051","sha256:f85d04aaa1f0325d05b3da9844c0abbc2c33b3f4d2112ccbec2f5ae687ebc462"]}],"invalid_events":[],"applied_event_ids":["sha256:861da2e13905305ccbb09ae83241ffadf8bad72690d5c201770d548839ecc8bf","sha256:1ed8e1480881db62e0df8abd8824d5d051240fe7f3c8ea5526d78835f84b515c"],"state_sha256":"392ed12da5ac2b1f1865bb410aff900929a6caf1749dd6c36500576d46096e2a"}