{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2018:EMOOAPBVQVFLQWF2KWIOIBQYSH","short_pith_number":"pith:EMOOAPBV","canonical_record":{"source":{"id":"1810.10184","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.ins-det","submitted_at":"2018-10-24T04:23:13Z","cross_cats_sorted":["physics.app-ph","physics.optics"],"title_canon_sha256":"7abf36d4d0e3743f621ed7fba7eaf46b560fc3a54dde0c7b95607414c3dd9621","abstract_canon_sha256":"01ea87aa7871fb3edf87b22fbb979f56a08114249ff824b9b83a29b6dfc2a176"},"schema_version":"1.0"},"canonical_sha256":"231ce03c35854ab858ba5590e4061891df990374355533cf945c3a2aedf1e161","source":{"kind":"arxiv","id":"1810.10184","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1810.10184","created_at":"2026-05-17T23:57:21Z"},{"alias_kind":"arxiv_version","alias_value":"1810.10184v1","created_at":"2026-05-17T23:57:21Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1810.10184","created_at":"2026-05-17T23:57:21Z"},{"alias_kind":"pith_short_12","alias_value":"EMOOAPBVQVFL","created_at":"2026-05-18T12:32:22Z"},{"alias_kind":"pith_short_16","alias_value":"EMOOAPBVQVFLQWF2","created_at":"2026-05-18T12:32:22Z"},{"alias_kind":"pith_short_8","alias_value":"EMOOAPBV","created_at":"2026-05-18T12:32:22Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2018:EMOOAPBVQVFLQWF2KWIOIBQYSH","target":"record","payload":{"canonical_record":{"source":{"id":"1810.10184","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.ins-det","submitted_at":"2018-10-24T04:23:13Z","cross_cats_sorted":["physics.app-ph","physics.optics"],"title_canon_sha256":"7abf36d4d0e3743f621ed7fba7eaf46b560fc3a54dde0c7b95607414c3dd9621","abstract_canon_sha256":"01ea87aa7871fb3edf87b22fbb979f56a08114249ff824b9b83a29b6dfc2a176"},"schema_version":"1.0"},"canonical_sha256":"231ce03c35854ab858ba5590e4061891df990374355533cf945c3a2aedf1e161","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-17T23:57:21.280808Z","signature_b64":"u2d0PIrlM3zmIvlp8isZzbV/efhxJSfbRAfWU9LyqxRk1+CeuKj9zXlKRyNPu3EF/U8uOAQCb+ICroU5Pu0wCg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"231ce03c35854ab858ba5590e4061891df990374355533cf945c3a2aedf1e161","last_reissued_at":"2026-05-17T23:57:21.280116Z","signature_status":"signed_v1","first_computed_at":"2026-05-17T23:57:21.280116Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1810.10184","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:57:21Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"uXGGUKvs4vhV8FGKR2MR2VbDPYa4WTv8uKOGS4+OK1draWJ0Xkem13XI7n9BpEkkk2sNCsdqsTwHrqYepMhTBQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-06T13:08:39.322738Z"},"content_sha256":"67b55ee5092f86f94b8412739ebfe6d2271e6f5ba3183b5a6c399c131674783c","schema_version":"1.0","event_id":"sha256:67b55ee5092f86f94b8412739ebfe6d2271e6f5ba3183b5a6c399c131674783c"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2018:EMOOAPBVQVFLQWF2KWIOIBQYSH","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Deep learning enables high-throughput analysis of particle-aggregation-based bio-sensors imaged using holography","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.app-ph","physics.optics"],"primary_cat":"physics.ins-det","authors_text":"Alborz Feizi, Aniruddha Ray, Aydogan Ozcan, Eva Chen, Qingshan Wei, Xin Tong, Yichen Wu, Yi Luo","submitted_at":"2018-10-24T04:23:13Z","abstract_excerpt":"Aggregation-based assays, using micro- and nano-particles have been widely accepted as an efficient and cost-effective bio-sensing tool, particularly in microbiology, where particle clustering events are used as a metric to infer the presence of a specific target analyte and quantify its concentration. Here, we present a sensitive and automated readout method for aggregation-based assays using a wide-field lens-free on-chip microscope, with the ability to rapidly analyze and quantify microscopic particle aggregation events in 3D, using deep learning-based holographic image reconstruction. In t"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1810.10184","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:57:21Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Jr/8BnlIEO06y8XWkcOTwA8emmw13/tRpOcfodjXZ2AHYJeNRo8Z+kLXk08Sd4LIF9vEvEX7yV7EpCTG9W9YAA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-06T13:08:39.323406Z"},"content_sha256":"7e15f5d9c49ce7ce0c24090e1a70c0535102b36e555b7b62702f1abd571b00cc","schema_version":"1.0","event_id":"sha256:7e15f5d9c49ce7ce0c24090e1a70c0535102b36e555b7b62702f1abd571b00cc"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/EMOOAPBVQVFLQWF2KWIOIBQYSH/bundle.json","state_url":"https://pith.science/pith/EMOOAPBVQVFLQWF2KWIOIBQYSH/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/EMOOAPBVQVFLQWF2KWIOIBQYSH/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-06T13:08:39Z","links":{"resolver":"https://pith.science/pith/EMOOAPBVQVFLQWF2KWIOIBQYSH","bundle":"https://pith.science/pith/EMOOAPBVQVFLQWF2KWIOIBQYSH/bundle.json","state":"https://pith.science/pith/EMOOAPBVQVFLQWF2KWIOIBQYSH/state.json","well_known_bundle":"https://pith.science/.well-known/pith/EMOOAPBVQVFLQWF2KWIOIBQYSH/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2018:EMOOAPBVQVFLQWF2KWIOIBQYSH","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"01ea87aa7871fb3edf87b22fbb979f56a08114249ff824b9b83a29b6dfc2a176","cross_cats_sorted":["physics.app-ph","physics.optics"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.ins-det","submitted_at":"2018-10-24T04:23:13Z","title_canon_sha256":"7abf36d4d0e3743f621ed7fba7eaf46b560fc3a54dde0c7b95607414c3dd9621"},"schema_version":"1.0","source":{"id":"1810.10184","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1810.10184","created_at":"2026-05-17T23:57:21Z"},{"alias_kind":"arxiv_version","alias_value":"1810.10184v1","created_at":"2026-05-17T23:57:21Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1810.10184","created_at":"2026-05-17T23:57:21Z"},{"alias_kind":"pith_short_12","alias_value":"EMOOAPBVQVFL","created_at":"2026-05-18T12:32:22Z"},{"alias_kind":"pith_short_16","alias_value":"EMOOAPBVQVFLQWF2","created_at":"2026-05-18T12:32:22Z"},{"alias_kind":"pith_short_8","alias_value":"EMOOAPBV","created_at":"2026-05-18T12:32:22Z"}],"graph_snapshots":[{"event_id":"sha256:7e15f5d9c49ce7ce0c24090e1a70c0535102b36e555b7b62702f1abd571b00cc","target":"graph","created_at":"2026-05-17T23:57:21Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Aggregation-based assays, using micro- and nano-particles have been widely accepted as an efficient and cost-effective bio-sensing tool, particularly in microbiology, where particle clustering events are used as a metric to infer the presence of a specific target analyte and quantify its concentration. Here, we present a sensitive and automated readout method for aggregation-based assays using a wide-field lens-free on-chip microscope, with the ability to rapidly analyze and quantify microscopic particle aggregation events in 3D, using deep learning-based holographic image reconstruction. In t","authors_text":"Alborz Feizi, Aniruddha Ray, Aydogan Ozcan, Eva Chen, Qingshan Wei, Xin Tong, Yichen Wu, Yi Luo","cross_cats":["physics.app-ph","physics.optics"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.ins-det","submitted_at":"2018-10-24T04:23:13Z","title":"Deep learning enables high-throughput analysis of particle-aggregation-based bio-sensors imaged using holography"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1810.10184","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:67b55ee5092f86f94b8412739ebfe6d2271e6f5ba3183b5a6c399c131674783c","target":"record","created_at":"2026-05-17T23:57:21Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"01ea87aa7871fb3edf87b22fbb979f56a08114249ff824b9b83a29b6dfc2a176","cross_cats_sorted":["physics.app-ph","physics.optics"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.ins-det","submitted_at":"2018-10-24T04:23:13Z","title_canon_sha256":"7abf36d4d0e3743f621ed7fba7eaf46b560fc3a54dde0c7b95607414c3dd9621"},"schema_version":"1.0","source":{"id":"1810.10184","kind":"arxiv","version":1}},"canonical_sha256":"231ce03c35854ab858ba5590e4061891df990374355533cf945c3a2aedf1e161","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"231ce03c35854ab858ba5590e4061891df990374355533cf945c3a2aedf1e161","first_computed_at":"2026-05-17T23:57:21.280116Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-17T23:57:21.280116Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"u2d0PIrlM3zmIvlp8isZzbV/efhxJSfbRAfWU9LyqxRk1+CeuKj9zXlKRyNPu3EF/U8uOAQCb+ICroU5Pu0wCg==","signature_status":"signed_v1","signed_at":"2026-05-17T23:57:21.280808Z","signed_message":"canonical_sha256_bytes"},"source_id":"1810.10184","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:67b55ee5092f86f94b8412739ebfe6d2271e6f5ba3183b5a6c399c131674783c","sha256:7e15f5d9c49ce7ce0c24090e1a70c0535102b36e555b7b62702f1abd571b00cc"],"state_sha256":"40fb887314e9de8a57c410b8f818311f3464f8b55e8b147fbd2589937e022baa"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"psGHFxKoV6Df2wVSxKe6YUM47Fyx+9M/fL9C+rzYr3XGPdkMtDRx8A3jqIZnPi3r8yad1MDDOO+m8/smmxeqCw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-06T13:08:39.326915Z","bundle_sha256":"09d495e2b0d74abee96712ea63c6ac4d59658760d6869118d6476ff5601075ab"}}