{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2021:EOGI3ZHEHY2EG7HLHWBRRI2FXC","short_pith_number":"pith:EOGI3ZHE","canonical_record":{"source":{"id":"2104.08237","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2021-04-16T17:16:35Z","cross_cats_sorted":["cs.LG"],"title_canon_sha256":"d1ea11256b8076d18300a0cc7976fa28ac14814d3148b4c544f5c26a213fe046","abstract_canon_sha256":"54fa3f62cef302633166db7ea5a63af34cdec4ece68110b56942cfea81b425a7"},"schema_version":"1.0"},"canonical_sha256":"238c8de4e43e34437ceb3d8318a345b8b51c8b76bf12c43147aa9a54a5b6b4d6","source":{"kind":"arxiv","id":"2104.08237","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2104.08237","created_at":"2026-07-05T02:32:42Z"},{"alias_kind":"arxiv_version","alias_value":"2104.08237v1","created_at":"2026-07-05T02:32:42Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2104.08237","created_at":"2026-07-05T02:32:42Z"},{"alias_kind":"pith_short_12","alias_value":"EOGI3ZHEHY2E","created_at":"2026-07-05T02:32:42Z"},{"alias_kind":"pith_short_16","alias_value":"EOGI3ZHEHY2EG7HL","created_at":"2026-07-05T02:32:42Z"},{"alias_kind":"pith_short_8","alias_value":"EOGI3ZHE","created_at":"2026-07-05T02:32:42Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2021:EOGI3ZHEHY2EG7HLHWBRRI2FXC","target":"record","payload":{"canonical_record":{"source":{"id":"2104.08237","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2021-04-16T17:16:35Z","cross_cats_sorted":["cs.LG"],"title_canon_sha256":"d1ea11256b8076d18300a0cc7976fa28ac14814d3148b4c544f5c26a213fe046","abstract_canon_sha256":"54fa3f62cef302633166db7ea5a63af34cdec4ece68110b56942cfea81b425a7"},"schema_version":"1.0"},"canonical_sha256":"238c8de4e43e34437ceb3d8318a345b8b51c8b76bf12c43147aa9a54a5b6b4d6","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T02:32:42.396974Z","signature_b64":"PgLaT6a/EzjbHb9Bg+dIL+JxOqYUI5+7veGyIYn3UgdBpeaMs3Vw79n4IXVVvsZ26tKOvlBUjoIvfIgOa8KPBQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"238c8de4e43e34437ceb3d8318a345b8b51c8b76bf12c43147aa9a54a5b6b4d6","last_reissued_at":"2026-07-05T02:32:42.396506Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T02:32:42.396506Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2104.08237","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T02:32:42Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"qushq3MqKQxAywotpLUNVScV9iVq0Y3mXTbJDwoRhkfceJIvHRUgXms5lVC/w/C5SNhiZMqz1R4dzfquVAwKBw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-21T14:45:06.562359Z"},"content_sha256":"b6f4c9e6e05d5dae093e76fdb0a5312699450b7a9b2e6e0919d5c30a40f4a8fa","schema_version":"1.0","event_id":"sha256:b6f4c9e6e05d5dae093e76fdb0a5312699450b7a9b2e6e0919d5c30a40f4a8fa"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2021:EOGI3ZHEHY2EG7HLHWBRRI2FXC","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Predicting the Binding of SARS-CoV-2 Peptides to the Major Histocompatibility Complex with Recurrent Neural Networks","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cs.LG"],"primary_cat":"q-bio.QM","authors_text":"Eva Weicken, Johanna Vielhaben, Markus Wenzel, Nils Strodthoff","submitted_at":"2021-04-16T17:16:35Z","abstract_excerpt":"Predicting the binding of viral peptides to the major histocompatibility complex with machine learning can potentially extend the computational immunology toolkit for vaccine development, and serve as a key component in the fight against a pandemic. In this work, we adapt and extend USMPep, a recently proposed, conceptually simple prediction algorithm based on recurrent neural networks. Most notably, we combine regressors (binding affinity data) and classifiers (mass spectrometry data) from qualitatively different data sources to obtain a more comprehensive prediction tool. We evaluate the per"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2104.08237","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2104.08237/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T02:32:42Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"DXvcuuqbw1O6baZP64fVPAL7CGyLix6F2Arz6Gu7FnEneK2qlbFeqQOEpz9eaVUNxfKrp7b239byKAIYR8uaAg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-21T14:45:06.562850Z"},"content_sha256":"331ef1bdd96b20751caa23bd69150299591a47360db917fe97e9f7d1737ea659","schema_version":"1.0","event_id":"sha256:331ef1bdd96b20751caa23bd69150299591a47360db917fe97e9f7d1737ea659"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/EOGI3ZHEHY2EG7HLHWBRRI2FXC/bundle.json","state_url":"https://pith.science/pith/EOGI3ZHEHY2EG7HLHWBRRI2FXC/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/EOGI3ZHEHY2EG7HLHWBRRI2FXC/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-21T14:45:06Z","links":{"resolver":"https://pith.science/pith/EOGI3ZHEHY2EG7HLHWBRRI2FXC","bundle":"https://pith.science/pith/EOGI3ZHEHY2EG7HLHWBRRI2FXC/bundle.json","state":"https://pith.science/pith/EOGI3ZHEHY2EG7HLHWBRRI2FXC/state.json","well_known_bundle":"https://pith.science/.well-known/pith/EOGI3ZHEHY2EG7HLHWBRRI2FXC/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2021:EOGI3ZHEHY2EG7HLHWBRRI2FXC","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"54fa3f62cef302633166db7ea5a63af34cdec4ece68110b56942cfea81b425a7","cross_cats_sorted":["cs.LG"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2021-04-16T17:16:35Z","title_canon_sha256":"d1ea11256b8076d18300a0cc7976fa28ac14814d3148b4c544f5c26a213fe046"},"schema_version":"1.0","source":{"id":"2104.08237","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2104.08237","created_at":"2026-07-05T02:32:42Z"},{"alias_kind":"arxiv_version","alias_value":"2104.08237v1","created_at":"2026-07-05T02:32:42Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2104.08237","created_at":"2026-07-05T02:32:42Z"},{"alias_kind":"pith_short_12","alias_value":"EOGI3ZHEHY2E","created_at":"2026-07-05T02:32:42Z"},{"alias_kind":"pith_short_16","alias_value":"EOGI3ZHEHY2EG7HL","created_at":"2026-07-05T02:32:42Z"},{"alias_kind":"pith_short_8","alias_value":"EOGI3ZHE","created_at":"2026-07-05T02:32:42Z"}],"graph_snapshots":[{"event_id":"sha256:331ef1bdd96b20751caa23bd69150299591a47360db917fe97e9f7d1737ea659","target":"graph","created_at":"2026-07-05T02:32:42Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2104.08237/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Predicting the binding of viral peptides to the major histocompatibility complex with machine learning can potentially extend the computational immunology toolkit for vaccine development, and serve as a key component in the fight against a pandemic. In this work, we adapt and extend USMPep, a recently proposed, conceptually simple prediction algorithm based on recurrent neural networks. Most notably, we combine regressors (binding affinity data) and classifiers (mass spectrometry data) from qualitatively different data sources to obtain a more comprehensive prediction tool. We evaluate the per","authors_text":"Eva Weicken, Johanna Vielhaben, Markus Wenzel, Nils Strodthoff","cross_cats":["cs.LG"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2021-04-16T17:16:35Z","title":"Predicting the Binding of SARS-CoV-2 Peptides to the Major Histocompatibility Complex with Recurrent Neural Networks"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2104.08237","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:b6f4c9e6e05d5dae093e76fdb0a5312699450b7a9b2e6e0919d5c30a40f4a8fa","target":"record","created_at":"2026-07-05T02:32:42Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"54fa3f62cef302633166db7ea5a63af34cdec4ece68110b56942cfea81b425a7","cross_cats_sorted":["cs.LG"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2021-04-16T17:16:35Z","title_canon_sha256":"d1ea11256b8076d18300a0cc7976fa28ac14814d3148b4c544f5c26a213fe046"},"schema_version":"1.0","source":{"id":"2104.08237","kind":"arxiv","version":1}},"canonical_sha256":"238c8de4e43e34437ceb3d8318a345b8b51c8b76bf12c43147aa9a54a5b6b4d6","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"238c8de4e43e34437ceb3d8318a345b8b51c8b76bf12c43147aa9a54a5b6b4d6","first_computed_at":"2026-07-05T02:32:42.396506Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T02:32:42.396506Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"PgLaT6a/EzjbHb9Bg+dIL+JxOqYUI5+7veGyIYn3UgdBpeaMs3Vw79n4IXVVvsZ26tKOvlBUjoIvfIgOa8KPBQ==","signature_status":"signed_v1","signed_at":"2026-07-05T02:32:42.396974Z","signed_message":"canonical_sha256_bytes"},"source_id":"2104.08237","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:b6f4c9e6e05d5dae093e76fdb0a5312699450b7a9b2e6e0919d5c30a40f4a8fa","sha256:331ef1bdd96b20751caa23bd69150299591a47360db917fe97e9f7d1737ea659"],"state_sha256":"c956d7b38d3b09c7970ce2c95cc57d9c94dd51250506f0ba21dbcdfa52236430"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"t8tnh+DGoRqOjSkD5gc2UgNp7Q9nBJn59Tk5jJxdH6nwYHV8D7GSWH1EjYWdhiwzd9l2tUrgB/0hY8CKIIuZCw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-21T14:45:06.567038Z","bundle_sha256":"86dae7a9a616732cea2f8cf892801f4dd4e0c35aa5d6b23027f8655c9d0417e1"}}