{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2024:ES5FM4ZZWYQGWNK5OOOEMUEQXK","short_pith_number":"pith:ES5FM4ZZ","canonical_record":{"source":{"id":"2401.05654","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.AI","submitted_at":"2024-01-11T04:25:06Z","cross_cats_sorted":["cs.CL","cs.LG"],"title_canon_sha256":"f88a8dfa11a7233e41ad7abcd8e39b38b2ea67fff560a8a9ddaebf4aebf7ddc0","abstract_canon_sha256":"0b912e6e393711d014b3109099c06a74e95e66e55c6d1d9464cf67e3729f43e9"},"schema_version":"1.0"},"canonical_sha256":"24ba567339b6206b355d739c465090ba93ca963526187b2aab89bd2c15d7fb68","source":{"kind":"arxiv","id":"2401.05654","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2401.05654","created_at":"2026-07-05T07:32:33Z"},{"alias_kind":"arxiv_version","alias_value":"2401.05654v1","created_at":"2026-07-05T07:32:33Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2401.05654","created_at":"2026-07-05T07:32:33Z"},{"alias_kind":"pith_short_12","alias_value":"ES5FM4ZZWYQG","created_at":"2026-07-05T07:32:33Z"},{"alias_kind":"pith_short_16","alias_value":"ES5FM4ZZWYQGWNK5","created_at":"2026-07-05T07:32:33Z"},{"alias_kind":"pith_short_8","alias_value":"ES5FM4ZZ","created_at":"2026-07-05T07:32:33Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2024:ES5FM4ZZWYQGWNK5OOOEMUEQXK","target":"record","payload":{"canonical_record":{"source":{"id":"2401.05654","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.AI","submitted_at":"2024-01-11T04:25:06Z","cross_cats_sorted":["cs.CL","cs.LG"],"title_canon_sha256":"f88a8dfa11a7233e41ad7abcd8e39b38b2ea67fff560a8a9ddaebf4aebf7ddc0","abstract_canon_sha256":"0b912e6e393711d014b3109099c06a74e95e66e55c6d1d9464cf67e3729f43e9"},"schema_version":"1.0"},"canonical_sha256":"24ba567339b6206b355d739c465090ba93ca963526187b2aab89bd2c15d7fb68","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T07:32:33.117117Z","signature_b64":"4Q3CXgXnx7FnbTcyJb02tBWGZrS4Rkbv/y31cWC5Pab9NR5xYN+5AzBRPrKJO+nEuGRKOqpeUB1d/Y09U2DTBw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"24ba567339b6206b355d739c465090ba93ca963526187b2aab89bd2c15d7fb68","last_reissued_at":"2026-07-05T07:32:33.116699Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T07:32:33.116699Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2401.05654","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T07:32:33Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"ufX5dWTavNqwnsAb4XzryM/iMvaaRsNTx+PP7XLamOMYYlrcRqdIBMlDtH7rmYS0sZ5QJT90iScUEvlMvg2TBw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-01T09:37:33.682158Z"},"content_sha256":"1f63c6c0643135fc61c13c71c1210e9805d5992779997a15a4a860225f62ef58","schema_version":"1.0","event_id":"sha256:1f63c6c0643135fc61c13c71c1210e9805d5992779997a15a4a860225f62ef58"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2024:ES5FM4ZZWYQGWNK5OOOEMUEQXK","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Towards Conversational Diagnostic AI","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cs.CL","cs.LG"],"primary_cat":"cs.AI","authors_text":"Alan Karthikesalingam, Albert Webson, Amy Wang, Anil Palepu, Brenna Li, Christopher Semturs, Greg S Corrado, Jan Freyberg, Joelle Barral, Juraj Gottweis, Karan Singhal, Katherine Chou, Kavita Kulkarni, Khaled Saab, Le Hou, Mike Schaekermann, Mohamed Amin, Nenad Tomasev, Ryutaro Tanno, Shekoofeh Azizi, S Sara Mahdavi, Tao Tu, Vivek Natarajan, Yong Cheng, Yossi Matias","submitted_at":"2024-01-11T04:25:06Z","abstract_excerpt":"At the heart of medicine lies the physician-patient dialogue, where skillful history-taking paves the way for accurate diagnosis, effective management, and enduring trust. Artificial Intelligence (AI) systems capable of diagnostic dialogue could increase accessibility, consistency, and quality of care. However, approximating clinicians' expertise is an outstanding grand challenge. Here, we introduce AMIE (Articulate Medical Intelligence Explorer), a Large Language Model (LLM) based AI system optimized for diagnostic dialogue.\n  AMIE uses a novel self-play based simulated environment with autom"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2401.05654","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2401.05654/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T07:32:33Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"6av7Cgwbx69vlfWm5Fr1WuLb72T9yL/vOm30+QELbTVNpEoe0xHzmwtO/Bws38q9TIodHAtlJSh9onRATgf5AA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-01T09:37:33.682519Z"},"content_sha256":"52689bd537cec29b304ca2bd58f9b21dc47a59f5056236faa2c8ac045d26c036","schema_version":"1.0","event_id":"sha256:52689bd537cec29b304ca2bd58f9b21dc47a59f5056236faa2c8ac045d26c036"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/ES5FM4ZZWYQGWNK5OOOEMUEQXK/bundle.json","state_url":"https://pith.science/pith/ES5FM4ZZWYQGWNK5OOOEMUEQXK/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/ES5FM4ZZWYQGWNK5OOOEMUEQXK/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-01T09:37:33Z","links":{"resolver":"https://pith.science/pith/ES5FM4ZZWYQGWNK5OOOEMUEQXK","bundle":"https://pith.science/pith/ES5FM4ZZWYQGWNK5OOOEMUEQXK/bundle.json","state":"https://pith.science/pith/ES5FM4ZZWYQGWNK5OOOEMUEQXK/state.json","well_known_bundle":"https://pith.science/.well-known/pith/ES5FM4ZZWYQGWNK5OOOEMUEQXK/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2024:ES5FM4ZZWYQGWNK5OOOEMUEQXK","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"0b912e6e393711d014b3109099c06a74e95e66e55c6d1d9464cf67e3729f43e9","cross_cats_sorted":["cs.CL","cs.LG"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.AI","submitted_at":"2024-01-11T04:25:06Z","title_canon_sha256":"f88a8dfa11a7233e41ad7abcd8e39b38b2ea67fff560a8a9ddaebf4aebf7ddc0"},"schema_version":"1.0","source":{"id":"2401.05654","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2401.05654","created_at":"2026-07-05T07:32:33Z"},{"alias_kind":"arxiv_version","alias_value":"2401.05654v1","created_at":"2026-07-05T07:32:33Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2401.05654","created_at":"2026-07-05T07:32:33Z"},{"alias_kind":"pith_short_12","alias_value":"ES5FM4ZZWYQG","created_at":"2026-07-05T07:32:33Z"},{"alias_kind":"pith_short_16","alias_value":"ES5FM4ZZWYQGWNK5","created_at":"2026-07-05T07:32:33Z"},{"alias_kind":"pith_short_8","alias_value":"ES5FM4ZZ","created_at":"2026-07-05T07:32:33Z"}],"graph_snapshots":[{"event_id":"sha256:52689bd537cec29b304ca2bd58f9b21dc47a59f5056236faa2c8ac045d26c036","target":"graph","created_at":"2026-07-05T07:32:33Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2401.05654/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"At the heart of medicine lies the physician-patient dialogue, where skillful history-taking paves the way for accurate diagnosis, effective management, and enduring trust. Artificial Intelligence (AI) systems capable of diagnostic dialogue could increase accessibility, consistency, and quality of care. However, approximating clinicians' expertise is an outstanding grand challenge. Here, we introduce AMIE (Articulate Medical Intelligence Explorer), a Large Language Model (LLM) based AI system optimized for diagnostic dialogue.\n  AMIE uses a novel self-play based simulated environment with autom","authors_text":"Alan Karthikesalingam, Albert Webson, Amy Wang, Anil Palepu, Brenna Li, Christopher Semturs, Greg S Corrado, Jan Freyberg, Joelle Barral, Juraj Gottweis, Karan Singhal, Katherine Chou, Kavita Kulkarni, Khaled Saab, Le Hou, Mike Schaekermann, Mohamed Amin, Nenad Tomasev, Ryutaro Tanno, Shekoofeh Azizi, S Sara Mahdavi, Tao Tu, Vivek Natarajan, Yong Cheng, Yossi Matias","cross_cats":["cs.CL","cs.LG"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.AI","submitted_at":"2024-01-11T04:25:06Z","title":"Towards Conversational Diagnostic AI"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2401.05654","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:1f63c6c0643135fc61c13c71c1210e9805d5992779997a15a4a860225f62ef58","target":"record","created_at":"2026-07-05T07:32:33Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"0b912e6e393711d014b3109099c06a74e95e66e55c6d1d9464cf67e3729f43e9","cross_cats_sorted":["cs.CL","cs.LG"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.AI","submitted_at":"2024-01-11T04:25:06Z","title_canon_sha256":"f88a8dfa11a7233e41ad7abcd8e39b38b2ea67fff560a8a9ddaebf4aebf7ddc0"},"schema_version":"1.0","source":{"id":"2401.05654","kind":"arxiv","version":1}},"canonical_sha256":"24ba567339b6206b355d739c465090ba93ca963526187b2aab89bd2c15d7fb68","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"24ba567339b6206b355d739c465090ba93ca963526187b2aab89bd2c15d7fb68","first_computed_at":"2026-07-05T07:32:33.116699Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T07:32:33.116699Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"4Q3CXgXnx7FnbTcyJb02tBWGZrS4Rkbv/y31cWC5Pab9NR5xYN+5AzBRPrKJO+nEuGRKOqpeUB1d/Y09U2DTBw==","signature_status":"signed_v1","signed_at":"2026-07-05T07:32:33.117117Z","signed_message":"canonical_sha256_bytes"},"source_id":"2401.05654","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:1f63c6c0643135fc61c13c71c1210e9805d5992779997a15a4a860225f62ef58","sha256:52689bd537cec29b304ca2bd58f9b21dc47a59f5056236faa2c8ac045d26c036"],"state_sha256":"547381784eecbb8d949fec82deeb7db3d6a62dbacf425c192bae4d25c686a451"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"LJ+nfJ4N6GkWZhLL5sgKd0QcruYDsduXydP5DqnXaMTgEKBbbV4KDm36JP/2WLtnLMPcreS0j3TUfP7+F7euAw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-01T09:37:33.685783Z","bundle_sha256":"c0ca850b6a0d8dc223a5d247b714bee92989b43554b409a82c3d5f5ce99e6a70"}}