{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2018:ESWUJSE5I6NDRIZDGWQOWGIGLG","short_pith_number":"pith:ESWUJSE5","canonical_record":{"source":{"id":"1802.06406","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2018-02-18T17:10:59Z","cross_cats_sorted":["q-bio.GN"],"title_canon_sha256":"ef025c86daf2ac4d7d7e0a64a244d4b9d3e045e0fbae09306649a85fbddceed8","abstract_canon_sha256":"7d38e0e8bae33d9e724e466f38d471a4480fa90fba1c1f63d61f1601f40423a5"},"schema_version":"1.0"},"canonical_sha256":"24ad44c89d479a38a32335a0eb190659b65e4bcc62098e0adf3e43f43b952604","source":{"kind":"arxiv","id":"1802.06406","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1802.06406","created_at":"2026-05-18T00:00:21Z"},{"alias_kind":"arxiv_version","alias_value":"1802.06406v1","created_at":"2026-05-18T00:00:21Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1802.06406","created_at":"2026-05-18T00:00:21Z"},{"alias_kind":"pith_short_12","alias_value":"ESWUJSE5I6ND","created_at":"2026-05-18T12:32:22Z"},{"alias_kind":"pith_short_16","alias_value":"ESWUJSE5I6NDRIZD","created_at":"2026-05-18T12:32:22Z"},{"alias_kind":"pith_short_8","alias_value":"ESWUJSE5","created_at":"2026-05-18T12:32:22Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2018:ESWUJSE5I6NDRIZDGWQOWGIGLG","target":"record","payload":{"canonical_record":{"source":{"id":"1802.06406","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2018-02-18T17:10:59Z","cross_cats_sorted":["q-bio.GN"],"title_canon_sha256":"ef025c86daf2ac4d7d7e0a64a244d4b9d3e045e0fbae09306649a85fbddceed8","abstract_canon_sha256":"7d38e0e8bae33d9e724e466f38d471a4480fa90fba1c1f63d61f1601f40423a5"},"schema_version":"1.0"},"canonical_sha256":"24ad44c89d479a38a32335a0eb190659b65e4bcc62098e0adf3e43f43b952604","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:00:21.953783Z","signature_b64":"rppEWMDVzNoDn9RxcF3Ec4uBMb1DAqpJX5kyGBRLBfOZdkVOfAcoOWIrius7XwKq3Dm5g/bsI9PmemOrLz45Bw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"24ad44c89d479a38a32335a0eb190659b65e4bcc62098e0adf3e43f43b952604","last_reissued_at":"2026-05-18T00:00:21.953017Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:00:21.953017Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1802.06406","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:00:21Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"RK3iGIg0qSbU2TXYVuMfl48MJb5FWuLLSoHurvUVoOe7EFuGeWF9Tk9YdeNWQgtmjQufQduEKitIAuk65DlDCQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-31T21:36:32.136235Z"},"content_sha256":"5c596342b9b94985cc3ad8c795519b134aa1f7d319de61fb8fed178ec4210db3","schema_version":"1.0","event_id":"sha256:5c596342b9b94985cc3ad8c795519b134aa1f7d319de61fb8fed178ec4210db3"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2018:ESWUJSE5I6NDRIZDGWQOWGIGLG","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Predicting B Cell Receptor Substitution Profiles Using Public Repertoire Data","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.GN"],"primary_cat":"q-bio.BM","authors_text":"Amrit Dhar, Frederick A. Matsen IV, Kristian Davidsen, Vladimir N. Minin","submitted_at":"2018-02-18T17:10:59Z","abstract_excerpt":"B cells develop high affinity receptors during the course of affinity maturation, a cyclic process of mutation and selection. At the end of affinity maturation, a number of cells sharing the same ancestor (i.e. in the same \"clonal family\") are released from the germinal center, their amino acid frequency profile reflects the allowed and disallowed substitutions at each position. These clonal-family-specific frequency profiles, called \"substitution profiles\", are useful for studying the course of affinity maturation as well as for antibody engineering purposes. However, most often only a single"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1802.06406","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:00:21Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"shb414Y3KnnRQhGTAQ5qjgFmvaXpzbypZq1Q/zHUOIv/t0kvtevrOiHASoEEXn7UHYBSUnNsSC1yYj1LvqZ1Cg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-31T21:36:32.136885Z"},"content_sha256":"bb89da9081bfff6c1703ecc19846784ab2e347ffbdfe8dc0b5d85e9e4b0971c7","schema_version":"1.0","event_id":"sha256:bb89da9081bfff6c1703ecc19846784ab2e347ffbdfe8dc0b5d85e9e4b0971c7"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/ESWUJSE5I6NDRIZDGWQOWGIGLG/bundle.json","state_url":"https://pith.science/pith/ESWUJSE5I6NDRIZDGWQOWGIGLG/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/ESWUJSE5I6NDRIZDGWQOWGIGLG/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-31T21:36:32Z","links":{"resolver":"https://pith.science/pith/ESWUJSE5I6NDRIZDGWQOWGIGLG","bundle":"https://pith.science/pith/ESWUJSE5I6NDRIZDGWQOWGIGLG/bundle.json","state":"https://pith.science/pith/ESWUJSE5I6NDRIZDGWQOWGIGLG/state.json","well_known_bundle":"https://pith.science/.well-known/pith/ESWUJSE5I6NDRIZDGWQOWGIGLG/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2018:ESWUJSE5I6NDRIZDGWQOWGIGLG","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"7d38e0e8bae33d9e724e466f38d471a4480fa90fba1c1f63d61f1601f40423a5","cross_cats_sorted":["q-bio.GN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2018-02-18T17:10:59Z","title_canon_sha256":"ef025c86daf2ac4d7d7e0a64a244d4b9d3e045e0fbae09306649a85fbddceed8"},"schema_version":"1.0","source":{"id":"1802.06406","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1802.06406","created_at":"2026-05-18T00:00:21Z"},{"alias_kind":"arxiv_version","alias_value":"1802.06406v1","created_at":"2026-05-18T00:00:21Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1802.06406","created_at":"2026-05-18T00:00:21Z"},{"alias_kind":"pith_short_12","alias_value":"ESWUJSE5I6ND","created_at":"2026-05-18T12:32:22Z"},{"alias_kind":"pith_short_16","alias_value":"ESWUJSE5I6NDRIZD","created_at":"2026-05-18T12:32:22Z"},{"alias_kind":"pith_short_8","alias_value":"ESWUJSE5","created_at":"2026-05-18T12:32:22Z"}],"graph_snapshots":[{"event_id":"sha256:bb89da9081bfff6c1703ecc19846784ab2e347ffbdfe8dc0b5d85e9e4b0971c7","target":"graph","created_at":"2026-05-18T00:00:21Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"B cells develop high affinity receptors during the course of affinity maturation, a cyclic process of mutation and selection. At the end of affinity maturation, a number of cells sharing the same ancestor (i.e. in the same \"clonal family\") are released from the germinal center, their amino acid frequency profile reflects the allowed and disallowed substitutions at each position. These clonal-family-specific frequency profiles, called \"substitution profiles\", are useful for studying the course of affinity maturation as well as for antibody engineering purposes. However, most often only a single","authors_text":"Amrit Dhar, Frederick A. Matsen IV, Kristian Davidsen, Vladimir N. Minin","cross_cats":["q-bio.GN"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2018-02-18T17:10:59Z","title":"Predicting B Cell Receptor Substitution Profiles Using Public Repertoire Data"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1802.06406","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:5c596342b9b94985cc3ad8c795519b134aa1f7d319de61fb8fed178ec4210db3","target":"record","created_at":"2026-05-18T00:00:21Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"7d38e0e8bae33d9e724e466f38d471a4480fa90fba1c1f63d61f1601f40423a5","cross_cats_sorted":["q-bio.GN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2018-02-18T17:10:59Z","title_canon_sha256":"ef025c86daf2ac4d7d7e0a64a244d4b9d3e045e0fbae09306649a85fbddceed8"},"schema_version":"1.0","source":{"id":"1802.06406","kind":"arxiv","version":1}},"canonical_sha256":"24ad44c89d479a38a32335a0eb190659b65e4bcc62098e0adf3e43f43b952604","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"24ad44c89d479a38a32335a0eb190659b65e4bcc62098e0adf3e43f43b952604","first_computed_at":"2026-05-18T00:00:21.953017Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:00:21.953017Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"rppEWMDVzNoDn9RxcF3Ec4uBMb1DAqpJX5kyGBRLBfOZdkVOfAcoOWIrius7XwKq3Dm5g/bsI9PmemOrLz45Bw==","signature_status":"signed_v1","signed_at":"2026-05-18T00:00:21.953783Z","signed_message":"canonical_sha256_bytes"},"source_id":"1802.06406","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:5c596342b9b94985cc3ad8c795519b134aa1f7d319de61fb8fed178ec4210db3","sha256:bb89da9081bfff6c1703ecc19846784ab2e347ffbdfe8dc0b5d85e9e4b0971c7"],"state_sha256":"9b644e3170601df32beec1f2447257310021f77bc0a5dfc68a78f5cd3d834fd6"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"guppIWP//hASaacRPgOh3MFxqN8+Dot9eLx+PAhWaO2UPgIZ/Z3/WykgFUsRz21DdsIYGaoVO+aAmzywcFxPCA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-31T21:36:32.140221Z","bundle_sha256":"32df3fa2a0247d7b1be09e8cfd2c116fefa66af2b3f9ff1de1d11f6a1c1d7a7c"}}