{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2017:ETRD7T6P3IXFZY6UKDPWS7WJE6","short_pith_number":"pith:ETRD7T6P","canonical_record":{"source":{"id":"1707.04862","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2017-07-16T11:10:06Z","cross_cats_sorted":["cond-mat.dis-nn","physics.bio-ph"],"title_canon_sha256":"6a18659535399c40dc6d7c24b72688557298e0f6bff8f38f653320b947c8f94b","abstract_canon_sha256":"5e5ef233882a20978508aafea4ccb8c3c2b22fe05d96d9f38d68677fd0408e63"},"schema_version":"1.0"},"canonical_sha256":"24e23fcfcfda2e5ce3d450df697ec9279dfa0128239bc220c6dce2030d8b4ba6","source":{"kind":"arxiv","id":"1707.04862","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1707.04862","created_at":"2026-05-18T00:11:43Z"},{"alias_kind":"arxiv_version","alias_value":"1707.04862v1","created_at":"2026-05-18T00:11:43Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1707.04862","created_at":"2026-05-18T00:11:43Z"},{"alias_kind":"pith_short_12","alias_value":"ETRD7T6P3IXF","created_at":"2026-05-18T12:31:12Z"},{"alias_kind":"pith_short_16","alias_value":"ETRD7T6P3IXFZY6U","created_at":"2026-05-18T12:31:12Z"},{"alias_kind":"pith_short_8","alias_value":"ETRD7T6P","created_at":"2026-05-18T12:31:12Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2017:ETRD7T6P3IXFZY6UKDPWS7WJE6","target":"record","payload":{"canonical_record":{"source":{"id":"1707.04862","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2017-07-16T11:10:06Z","cross_cats_sorted":["cond-mat.dis-nn","physics.bio-ph"],"title_canon_sha256":"6a18659535399c40dc6d7c24b72688557298e0f6bff8f38f653320b947c8f94b","abstract_canon_sha256":"5e5ef233882a20978508aafea4ccb8c3c2b22fe05d96d9f38d68677fd0408e63"},"schema_version":"1.0"},"canonical_sha256":"24e23fcfcfda2e5ce3d450df697ec9279dfa0128239bc220c6dce2030d8b4ba6","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:11:43.256446Z","signature_b64":"VC4rYv/S0kYDkFe6Qzt8ci7cLcEeskCi62Yw4p1isAl38OmCA41KiekJR28IBLnOgwPtcQ9PGscX4ZlKBhXsAQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"24e23fcfcfda2e5ce3d450df697ec9279dfa0128239bc220c6dce2030d8b4ba6","last_reissued_at":"2026-05-18T00:11:43.255915Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:11:43.255915Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1707.04862","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:11:43Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"10rPbQKzpvmGvbWBuVCdiSmnRK99jeZb+vYekoV3w6NmJ1422Wl2Hfu4gvElNNdY2sFZU9MkTy+hDMax1EyLCA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-07T17:54:03.597668Z"},"content_sha256":"e7f24ebd0ab2c2067d232fcbe15f4688e70bca156942fa9080a6ea60aaf25cbd","schema_version":"1.0","event_id":"sha256:e7f24ebd0ab2c2067d232fcbe15f4688e70bca156942fa9080a6ea60aaf25cbd"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2017:ETRD7T6P3IXFZY6UKDPWS7WJE6","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Metabolic plasticity in synthetic lethal mutants: viability at higher cost","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cond-mat.dis-nn","physics.bio-ph"],"primary_cat":"q-bio.MN","authors_text":"Francesco Alessandro Massucci, Francesc Sagu\\'es, M. \\'Angeles Serrano","submitted_at":"2017-07-16T11:10:06Z","abstract_excerpt":"The most frequent form of pairwise synthetic lethality (SL) in metabolic networks is known as plasticity synthetic lethality (PSL). It occurs when the simultaneous inhibition of paired functional and silent metabolic reactions or genes is lethal, while the default of the functional reaction or gene in the pair is backed up by the activation of the silent one. Based on a complex systems approach and by using computational techniques on bacterial genome-scale metabolic reconstructions, we found that the failure of the functional PSL partner triggers a critical reorganization of fluxes to ensure "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1707.04862","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:11:43Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"SmgdByzTJRKJ7X9XjnBzEG2BbuzZtZnZOx0b6qUkC8AzNmmd5pKtwPmk/kGfI9pebWVqH6/y8n26fJ+kFTmVBQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-07T17:54:03.598351Z"},"content_sha256":"7fd49489a328aaa66572a8f90be0019e5ac73206e960ff0cf93a316c9a289ce8","schema_version":"1.0","event_id":"sha256:7fd49489a328aaa66572a8f90be0019e5ac73206e960ff0cf93a316c9a289ce8"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/ETRD7T6P3IXFZY6UKDPWS7WJE6/bundle.json","state_url":"https://pith.science/pith/ETRD7T6P3IXFZY6UKDPWS7WJE6/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/ETRD7T6P3IXFZY6UKDPWS7WJE6/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-07T17:54:03Z","links":{"resolver":"https://pith.science/pith/ETRD7T6P3IXFZY6UKDPWS7WJE6","bundle":"https://pith.science/pith/ETRD7T6P3IXFZY6UKDPWS7WJE6/bundle.json","state":"https://pith.science/pith/ETRD7T6P3IXFZY6UKDPWS7WJE6/state.json","well_known_bundle":"https://pith.science/.well-known/pith/ETRD7T6P3IXFZY6UKDPWS7WJE6/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2017:ETRD7T6P3IXFZY6UKDPWS7WJE6","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"5e5ef233882a20978508aafea4ccb8c3c2b22fe05d96d9f38d68677fd0408e63","cross_cats_sorted":["cond-mat.dis-nn","physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2017-07-16T11:10:06Z","title_canon_sha256":"6a18659535399c40dc6d7c24b72688557298e0f6bff8f38f653320b947c8f94b"},"schema_version":"1.0","source":{"id":"1707.04862","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1707.04862","created_at":"2026-05-18T00:11:43Z"},{"alias_kind":"arxiv_version","alias_value":"1707.04862v1","created_at":"2026-05-18T00:11:43Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1707.04862","created_at":"2026-05-18T00:11:43Z"},{"alias_kind":"pith_short_12","alias_value":"ETRD7T6P3IXF","created_at":"2026-05-18T12:31:12Z"},{"alias_kind":"pith_short_16","alias_value":"ETRD7T6P3IXFZY6U","created_at":"2026-05-18T12:31:12Z"},{"alias_kind":"pith_short_8","alias_value":"ETRD7T6P","created_at":"2026-05-18T12:31:12Z"}],"graph_snapshots":[{"event_id":"sha256:7fd49489a328aaa66572a8f90be0019e5ac73206e960ff0cf93a316c9a289ce8","target":"graph","created_at":"2026-05-18T00:11:43Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"The most frequent form of pairwise synthetic lethality (SL) in metabolic networks is known as plasticity synthetic lethality (PSL). It occurs when the simultaneous inhibition of paired functional and silent metabolic reactions or genes is lethal, while the default of the functional reaction or gene in the pair is backed up by the activation of the silent one. Based on a complex systems approach and by using computational techniques on bacterial genome-scale metabolic reconstructions, we found that the failure of the functional PSL partner triggers a critical reorganization of fluxes to ensure ","authors_text":"Francesco Alessandro Massucci, Francesc Sagu\\'es, M. \\'Angeles Serrano","cross_cats":["cond-mat.dis-nn","physics.bio-ph"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2017-07-16T11:10:06Z","title":"Metabolic plasticity in synthetic lethal mutants: viability at higher cost"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1707.04862","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:e7f24ebd0ab2c2067d232fcbe15f4688e70bca156942fa9080a6ea60aaf25cbd","target":"record","created_at":"2026-05-18T00:11:43Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"5e5ef233882a20978508aafea4ccb8c3c2b22fe05d96d9f38d68677fd0408e63","cross_cats_sorted":["cond-mat.dis-nn","physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2017-07-16T11:10:06Z","title_canon_sha256":"6a18659535399c40dc6d7c24b72688557298e0f6bff8f38f653320b947c8f94b"},"schema_version":"1.0","source":{"id":"1707.04862","kind":"arxiv","version":1}},"canonical_sha256":"24e23fcfcfda2e5ce3d450df697ec9279dfa0128239bc220c6dce2030d8b4ba6","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"24e23fcfcfda2e5ce3d450df697ec9279dfa0128239bc220c6dce2030d8b4ba6","first_computed_at":"2026-05-18T00:11:43.255915Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:11:43.255915Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"VC4rYv/S0kYDkFe6Qzt8ci7cLcEeskCi62Yw4p1isAl38OmCA41KiekJR28IBLnOgwPtcQ9PGscX4ZlKBhXsAQ==","signature_status":"signed_v1","signed_at":"2026-05-18T00:11:43.256446Z","signed_message":"canonical_sha256_bytes"},"source_id":"1707.04862","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:e7f24ebd0ab2c2067d232fcbe15f4688e70bca156942fa9080a6ea60aaf25cbd","sha256:7fd49489a328aaa66572a8f90be0019e5ac73206e960ff0cf93a316c9a289ce8"],"state_sha256":"86717c41be162028a2b8df1d6afb9cebc53450a4329ca1abff0fcd37ba150367"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"VB9BkOrZpwGEaL674TS+XVTmatWiTVkPMrszByHRZME6jEoyGqd75dsUbbQni9IXu/UC/NX2RKhVQUJsB+94Dg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-07T17:54:03.603705Z","bundle_sha256":"00ac5819663d1f8f0ebbb4290db6a94b8b89cac18d81d104070866a6a966e4db"}}