{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2012:EWIJPNT73WG7U6P2UINN2EEGRS","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"ebf4499abce73b9614ebfb1a9f66538c9b7758234aabcd50e6e77bf3577dd40a","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2012-03-28T20:36:28Z","title_canon_sha256":"a2055facbc8d08d6566ddbe93d2709ab4ba948742c3426d32cb074f488364150"},"schema_version":"1.0","source":{"id":"1203.6372","kind":"arxiv","version":3}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1203.6372","created_at":"2026-05-18T03:30:42Z"},{"alias_kind":"arxiv_version","alias_value":"1203.6372v3","created_at":"2026-05-18T03:30:42Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1203.6372","created_at":"2026-05-18T03:30:42Z"},{"alias_kind":"pith_short_12","alias_value":"EWIJPNT73WG7","created_at":"2026-05-18T12:27:04Z"},{"alias_kind":"pith_short_16","alias_value":"EWIJPNT73WG7U6P2","created_at":"2026-05-18T12:27:04Z"},{"alias_kind":"pith_short_8","alias_value":"EWIJPNT7","created_at":"2026-05-18T12:27:04Z"}],"graph_snapshots":[{"event_id":"sha256:703fb3b35a2c3a7b73bc4ee85523ecdf9cb3723f5e26da913cb40250e7f8b891","target":"graph","created_at":"2026-05-18T03:30:42Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Motivation: Most existing methods for DNA sequence analysis rely on accurate sequences or genotypes. However, in applications of the next-generation sequencing (NGS), accurate genotypes may not be easily obtained (e.g. multi-sample low-coverage sequencing or somatic mutation discovery). These applications press for the development of new methods for analyzing sequence data with uncertainty.\n  Results: We present a statistical framework for calling SNPs, discovering somatic mutations, inferring population genetical parameters and performing association tests directly based on sequencing data wi","authors_text":"Heng Li","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2012-03-28T20:36:28Z","title":"A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1203.6372","kind":"arxiv","version":3},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:dcae75189e86d96bf12184218ad394cae5eb8b13f4dccda9c6d692e43b01bb03","target":"record","created_at":"2026-05-18T03:30:42Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"ebf4499abce73b9614ebfb1a9f66538c9b7758234aabcd50e6e77bf3577dd40a","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2012-03-28T20:36:28Z","title_canon_sha256":"a2055facbc8d08d6566ddbe93d2709ab4ba948742c3426d32cb074f488364150"},"schema_version":"1.0","source":{"id":"1203.6372","kind":"arxiv","version":3}},"canonical_sha256":"259097b67fdd8dfa79faa21add10868ca2210c4ae37395c3f89244f318daf5a5","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"259097b67fdd8dfa79faa21add10868ca2210c4ae37395c3f89244f318daf5a5","first_computed_at":"2026-05-18T03:30:42.243297Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T03:30:42.243297Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"STNEvn5lSr42Flk8NdTK3zsqt9tqB2Ih1NHVvi0t3r8xKleGZnxiQOei+LfCxLGbLEsq1Df1UsCJQ29VmTPzDg==","signature_status":"signed_v1","signed_at":"2026-05-18T03:30:42.244235Z","signed_message":"canonical_sha256_bytes"},"source_id":"1203.6372","source_kind":"arxiv","source_version":3}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:dcae75189e86d96bf12184218ad394cae5eb8b13f4dccda9c6d692e43b01bb03","sha256:703fb3b35a2c3a7b73bc4ee85523ecdf9cb3723f5e26da913cb40250e7f8b891"],"state_sha256":"89250cb9139adac8a90da19da779233af7b1ed20e474fa9d35aad907d6212765"}