{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2016:F3CBYRZN23DOR6VBV52ULLKXC2","short_pith_number":"pith:F3CBYRZN","schema_version":"1.0","canonical_sha256":"2ec41c472dd6c6e8faa1af7545ad57168c11b9a95e147a938ee2bfce0eb1b446","source":{"kind":"arxiv","id":"1610.00661","version":1},"attestation_state":"computed","paper":{"title":"3D hybrid modeling of vascular network formation","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.TO"],"primary_cat":"q-bio.QM","authors_text":"Barry D Hughes, Helen M Byrne, Holger Perfahl, Mark C Lloyd, Matthias Reuss, Philip K Maini, Tomas Alaracon","submitted_at":"2016-10-03T18:25:39Z","abstract_excerpt":"We develop an agent-based model of vasculogenesis, the de novo formation of blood vessels. Endothelial cells in the vessel network are viewed as linearly elastic spheres and are of two types: vessel elements are contained within the network; tip cells are located at endpoints. Tip cells move in response to forces due to interactions with neighbouring vessel elements, the local tissue environment, chemotaxis and a persistence force modeling their tendency to continue moving in the same direction. Vessel elements experience similar forces but not chemotaxis. An angular persistence force represen"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1610.00661","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2016-10-03T18:25:39Z","cross_cats_sorted":["q-bio.TO"],"title_canon_sha256":"0a489c949e85f220a6b1e308f175db9105f61dfb1341ab279eefc200e1ef34e4","abstract_canon_sha256":"4570a89da184a52f9e704f327f97db88439797450189174d51a675f76736ad6a"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:03:24.978372Z","signature_b64":"ELz1+j6J+tzLPoJNM0lJs8TFAioPOGUgJ986Td3dXS1wucrxOI9HJZxHHv2guZ6gwhywg/+KB404RkNp3rUUBg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"2ec41c472dd6c6e8faa1af7545ad57168c11b9a95e147a938ee2bfce0eb1b446","last_reissued_at":"2026-05-18T01:03:24.977884Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:03:24.977884Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"3D hybrid modeling of vascular network formation","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.TO"],"primary_cat":"q-bio.QM","authors_text":"Barry D Hughes, Helen M Byrne, Holger Perfahl, Mark C Lloyd, Matthias Reuss, Philip K Maini, Tomas Alaracon","submitted_at":"2016-10-03T18:25:39Z","abstract_excerpt":"We develop an agent-based model of vasculogenesis, the de novo formation of blood vessels. Endothelial cells in the vessel network are viewed as linearly elastic spheres and are of two types: vessel elements are contained within the network; tip cells are located at endpoints. Tip cells move in response to forces due to interactions with neighbouring vessel elements, the local tissue environment, chemotaxis and a persistence force modeling their tendency to continue moving in the same direction. Vessel elements experience similar forces but not chemotaxis. An angular persistence force represen"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1610.00661","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1610.00661","created_at":"2026-05-18T01:03:24.977956+00:00"},{"alias_kind":"arxiv_version","alias_value":"1610.00661v1","created_at":"2026-05-18T01:03:24.977956+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1610.00661","created_at":"2026-05-18T01:03:24.977956+00:00"},{"alias_kind":"pith_short_12","alias_value":"F3CBYRZN23DO","created_at":"2026-05-18T12:30:15.759754+00:00"},{"alias_kind":"pith_short_16","alias_value":"F3CBYRZN23DOR6VB","created_at":"2026-05-18T12:30:15.759754+00:00"},{"alias_kind":"pith_short_8","alias_value":"F3CBYRZN","created_at":"2026-05-18T12:30:15.759754+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":1,"internal_anchor_count":1,"sample":[{"citing_arxiv_id":"1907.08711","citing_title":"Topological Methods for Characterising Spatial Networks: A Case Study in Tumour Vasculature","ref_index":19,"is_internal_anchor":true}]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/F3CBYRZN23DOR6VBV52ULLKXC2","json":"https://pith.science/pith/F3CBYRZN23DOR6VBV52ULLKXC2.json","graph_json":"https://pith.science/api/pith-number/F3CBYRZN23DOR6VBV52ULLKXC2/graph.json","events_json":"https://pith.science/api/pith-number/F3CBYRZN23DOR6VBV52ULLKXC2/events.json","paper":"https://pith.science/paper/F3CBYRZN"},"agent_actions":{"view_html":"https://pith.science/pith/F3CBYRZN23DOR6VBV52ULLKXC2","download_json":"https://pith.science/pith/F3CBYRZN23DOR6VBV52ULLKXC2.json","view_paper":"https://pith.science/paper/F3CBYRZN","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1610.00661&json=true","fetch_graph":"https://pith.science/api/pith-number/F3CBYRZN23DOR6VBV52ULLKXC2/graph.json","fetch_events":"https://pith.science/api/pith-number/F3CBYRZN23DOR6VBV52ULLKXC2/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/F3CBYRZN23DOR6VBV52ULLKXC2/action/timestamp_anchor","attest_storage":"https://pith.science/pith/F3CBYRZN23DOR6VBV52ULLKXC2/action/storage_attestation","attest_author":"https://pith.science/pith/F3CBYRZN23DOR6VBV52ULLKXC2/action/author_attestation","sign_citation":"https://pith.science/pith/F3CBYRZN23DOR6VBV52ULLKXC2/action/citation_signature","submit_replication":"https://pith.science/pith/F3CBYRZN23DOR6VBV52ULLKXC2/action/replication_record"}},"created_at":"2026-05-18T01:03:24.977956+00:00","updated_at":"2026-05-18T01:03:24.977956+00:00"}