{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2020:FDTEQ5ZDRUBVVQK5TBN4ASAFUW","short_pith_number":"pith:FDTEQ5ZD","canonical_record":{"source":{"id":"2001.11663","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2020-01-31T05:23:23Z","cross_cats_sorted":["q-bio.CB","q-bio.TO"],"title_canon_sha256":"68f92137698657b25e974cc5c45f802f45b8efdd86caf4151a5ef260ea720ab9","abstract_canon_sha256":"132aa03994166a1c9a4959715bc039f01dbaffd75ddbe53301a2c70dc0d4649f"},"schema_version":"1.0"},"canonical_sha256":"28e64877238d035ac15d985bc04805a5af8dc58e31f991a20655a5ef189232d2","source":{"kind":"arxiv","id":"2001.11663","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2001.11663","created_at":"2026-07-05T01:00:49Z"},{"alias_kind":"arxiv_version","alias_value":"2001.11663v2","created_at":"2026-07-05T01:00:49Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2001.11663","created_at":"2026-07-05T01:00:49Z"},{"alias_kind":"pith_short_12","alias_value":"FDTEQ5ZDRUBV","created_at":"2026-07-05T01:00:49Z"},{"alias_kind":"pith_short_16","alias_value":"FDTEQ5ZDRUBVVQK5","created_at":"2026-07-05T01:00:49Z"},{"alias_kind":"pith_short_8","alias_value":"FDTEQ5ZD","created_at":"2026-07-05T01:00:49Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2020:FDTEQ5ZDRUBVVQK5TBN4ASAFUW","target":"record","payload":{"canonical_record":{"source":{"id":"2001.11663","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2020-01-31T05:23:23Z","cross_cats_sorted":["q-bio.CB","q-bio.TO"],"title_canon_sha256":"68f92137698657b25e974cc5c45f802f45b8efdd86caf4151a5ef260ea720ab9","abstract_canon_sha256":"132aa03994166a1c9a4959715bc039f01dbaffd75ddbe53301a2c70dc0d4649f"},"schema_version":"1.0"},"canonical_sha256":"28e64877238d035ac15d985bc04805a5af8dc58e31f991a20655a5ef189232d2","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T01:00:49.941908Z","signature_b64":"5x0eogYfannrizdZL2E5BenZpmqHQiys2+I2nsujyKnVlbpZfP4yQmMn3UwXRK2iPU0DlJlsC/DC8ka1U+aGAg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"28e64877238d035ac15d985bc04805a5af8dc58e31f991a20655a5ef189232d2","last_reissued_at":"2026-07-05T01:00:49.941436Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T01:00:49.941436Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2001.11663","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T01:00:49Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Tm3+f7BqLuPCkwy4mP6ZI+NLdcWa47q2ZBTmbqBRs/Q50u7Zcp1WDnN2qofS2weoV8s8YfYP54UFSct285SYAg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-19T12:59:12.763925Z"},"content_sha256":"2e9bea499a348269bb48ad2d8325695615d9c24cab5ab11cf662598dbf7b95bc","schema_version":"1.0","event_id":"sha256:2e9bea499a348269bb48ad2d8325695615d9c24cab5ab11cf662598dbf7b95bc"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2020:FDTEQ5ZDRUBVVQK5TBN4ASAFUW","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Leader-cell-driven epithelial sheet fingering","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.CB","q-bio.TO"],"primary_cat":"physics.bio-ph","authors_text":"Herbert Levine, Yanjun Yang","submitted_at":"2020-01-31T05:23:23Z","abstract_excerpt":"Collective cell migration is crucial in many biological processes such as wound healing, tissue morphogenesis, and tumor progression. The leading front of a collective migrating epithelial cell layer often destabilizes into multicellular finger-like protrusions, each of which is guided by a leader cell at the fingertip. Here, we develop a subcellular-element-based model of this fingering instability, which incorporates leader cells and other related properties of a monolayer of epithelial cells. Our model recovers multiple aspects of the dynamics, especially the traction force patterns and vel"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2001.11663","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2001.11663/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T01:00:49Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"LKcuo/J+baOERz9gRpwxiCA04fZEwXC7G8NghVtQaYU3qiw+mGS92FfGoFsM4VFKydUuvUSv1nvWWuy8z46eBA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-19T12:59:12.764463Z"},"content_sha256":"cf5fbe2ee5d2bcceb016824d789d4ebe4eb9f7b421ff8ffbe3a086747a4bbb3b","schema_version":"1.0","event_id":"sha256:cf5fbe2ee5d2bcceb016824d789d4ebe4eb9f7b421ff8ffbe3a086747a4bbb3b"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/FDTEQ5ZDRUBVVQK5TBN4ASAFUW/bundle.json","state_url":"https://pith.science/pith/FDTEQ5ZDRUBVVQK5TBN4ASAFUW/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/FDTEQ5ZDRUBVVQK5TBN4ASAFUW/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-19T12:59:12Z","links":{"resolver":"https://pith.science/pith/FDTEQ5ZDRUBVVQK5TBN4ASAFUW","bundle":"https://pith.science/pith/FDTEQ5ZDRUBVVQK5TBN4ASAFUW/bundle.json","state":"https://pith.science/pith/FDTEQ5ZDRUBVVQK5TBN4ASAFUW/state.json","well_known_bundle":"https://pith.science/.well-known/pith/FDTEQ5ZDRUBVVQK5TBN4ASAFUW/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2020:FDTEQ5ZDRUBVVQK5TBN4ASAFUW","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"132aa03994166a1c9a4959715bc039f01dbaffd75ddbe53301a2c70dc0d4649f","cross_cats_sorted":["q-bio.CB","q-bio.TO"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2020-01-31T05:23:23Z","title_canon_sha256":"68f92137698657b25e974cc5c45f802f45b8efdd86caf4151a5ef260ea720ab9"},"schema_version":"1.0","source":{"id":"2001.11663","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2001.11663","created_at":"2026-07-05T01:00:49Z"},{"alias_kind":"arxiv_version","alias_value":"2001.11663v2","created_at":"2026-07-05T01:00:49Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2001.11663","created_at":"2026-07-05T01:00:49Z"},{"alias_kind":"pith_short_12","alias_value":"FDTEQ5ZDRUBV","created_at":"2026-07-05T01:00:49Z"},{"alias_kind":"pith_short_16","alias_value":"FDTEQ5ZDRUBVVQK5","created_at":"2026-07-05T01:00:49Z"},{"alias_kind":"pith_short_8","alias_value":"FDTEQ5ZD","created_at":"2026-07-05T01:00:49Z"}],"graph_snapshots":[{"event_id":"sha256:cf5fbe2ee5d2bcceb016824d789d4ebe4eb9f7b421ff8ffbe3a086747a4bbb3b","target":"graph","created_at":"2026-07-05T01:00:49Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2001.11663/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Collective cell migration is crucial in many biological processes such as wound healing, tissue morphogenesis, and tumor progression. The leading front of a collective migrating epithelial cell layer often destabilizes into multicellular finger-like protrusions, each of which is guided by a leader cell at the fingertip. Here, we develop a subcellular-element-based model of this fingering instability, which incorporates leader cells and other related properties of a monolayer of epithelial cells. Our model recovers multiple aspects of the dynamics, especially the traction force patterns and vel","authors_text":"Herbert Levine, Yanjun Yang","cross_cats":["q-bio.CB","q-bio.TO"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2020-01-31T05:23:23Z","title":"Leader-cell-driven epithelial sheet fingering"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2001.11663","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:2e9bea499a348269bb48ad2d8325695615d9c24cab5ab11cf662598dbf7b95bc","target":"record","created_at":"2026-07-05T01:00:49Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"132aa03994166a1c9a4959715bc039f01dbaffd75ddbe53301a2c70dc0d4649f","cross_cats_sorted":["q-bio.CB","q-bio.TO"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2020-01-31T05:23:23Z","title_canon_sha256":"68f92137698657b25e974cc5c45f802f45b8efdd86caf4151a5ef260ea720ab9"},"schema_version":"1.0","source":{"id":"2001.11663","kind":"arxiv","version":2}},"canonical_sha256":"28e64877238d035ac15d985bc04805a5af8dc58e31f991a20655a5ef189232d2","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"28e64877238d035ac15d985bc04805a5af8dc58e31f991a20655a5ef189232d2","first_computed_at":"2026-07-05T01:00:49.941436Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T01:00:49.941436Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"5x0eogYfannrizdZL2E5BenZpmqHQiys2+I2nsujyKnVlbpZfP4yQmMn3UwXRK2iPU0DlJlsC/DC8ka1U+aGAg==","signature_status":"signed_v1","signed_at":"2026-07-05T01:00:49.941908Z","signed_message":"canonical_sha256_bytes"},"source_id":"2001.11663","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:2e9bea499a348269bb48ad2d8325695615d9c24cab5ab11cf662598dbf7b95bc","sha256:cf5fbe2ee5d2bcceb016824d789d4ebe4eb9f7b421ff8ffbe3a086747a4bbb3b"],"state_sha256":"2df9e95fcb2504f53037c0b0ca35b99710b57d14d64165e801bfbc59e6ec4c33"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"ypgoIOMKSg+dTUtYbVApmfABW7vtkDoCzgG9A5stVmImccI+l28exquzJT0Lifl3byXAZOulmUgPoHwtcbHbBQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-19T12:59:12.768175Z","bundle_sha256":"d850aace31ae0e751ebf5fa4d893fe4608cead0ed4dca6fae83329cef1088021"}}