{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2026:FLNUTXTW7AYI2I6DYRMIU5KV34","short_pith_number":"pith:FLNUTXTW","canonical_record":{"source":{"id":"2606.04021","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2026-06-01T09:39:22Z","cross_cats_sorted":["cs.LG"],"title_canon_sha256":"10c3faac0823f2585069d294fc9d0042feb0ee56740a98656d99fa5a6e5cc684","abstract_canon_sha256":"a677bc823d89f87c90fb6add6c16354a0c11c6cef04fe9c9999575f07bbfb015"},"schema_version":"1.0"},"canonical_sha256":"2adb49de76f8308d23c3c4588a7555df27d91c14424da0a1caad3b2ccca1ee94","source":{"kind":"arxiv","id":"2606.04021","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2606.04021","created_at":"2026-06-04T00:06:44Z"},{"alias_kind":"arxiv_version","alias_value":"2606.04021v1","created_at":"2026-06-04T00:06:44Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2606.04021","created_at":"2026-06-04T00:06:44Z"},{"alias_kind":"pith_short_12","alias_value":"FLNUTXTW7AYI","created_at":"2026-06-04T00:06:44Z"},{"alias_kind":"pith_short_16","alias_value":"FLNUTXTW7AYI2I6D","created_at":"2026-06-04T00:06:44Z"},{"alias_kind":"pith_short_8","alias_value":"FLNUTXTW","created_at":"2026-06-04T00:06:44Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2026:FLNUTXTW7AYI2I6DYRMIU5KV34","target":"record","payload":{"canonical_record":{"source":{"id":"2606.04021","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2026-06-01T09:39:22Z","cross_cats_sorted":["cs.LG"],"title_canon_sha256":"10c3faac0823f2585069d294fc9d0042feb0ee56740a98656d99fa5a6e5cc684","abstract_canon_sha256":"a677bc823d89f87c90fb6add6c16354a0c11c6cef04fe9c9999575f07bbfb015"},"schema_version":"1.0"},"canonical_sha256":"2adb49de76f8308d23c3c4588a7555df27d91c14424da0a1caad3b2ccca1ee94","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-06-04T00:06:44.653477Z","signature_b64":"XOADmgUVzDz4WfSmbVfzrrUqoIsEVvOdOlDvjW0h21XkVQ7gNtUIAeYpFRF6q2/4z/CbwIABNa/HwFANkgvqBA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"2adb49de76f8308d23c3c4588a7555df27d91c14424da0a1caad3b2ccca1ee94","last_reissued_at":"2026-06-04T00:06:44.653047Z","signature_status":"signed_v1","first_computed_at":"2026-06-04T00:06:44.653047Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2606.04021","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-06-04T00:06:44Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"UlrZxILsbhBSmrduNuVhhOv8v2Mp4bHRiMU9XQKLzUvlnFyC3eRieVHFtyDi5HHhI5pYPAsuJkcjL6Ls/j9ZBA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-11T08:26:52.995433Z"},"content_sha256":"89616c0a1b26e5d390e154d0935090c16f144253c24b8c0d34b7c703d090bbad","schema_version":"1.0","event_id":"sha256:89616c0a1b26e5d390e154d0935090c16f144253c24b8c0d34b7c703d090bbad"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2026:FLNUTXTW7AYI2I6DYRMIU5KV34","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Structure-Aware Prediction of PROTAC-Mediated Protein Degradability via Graph Neural Networks","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["cs.LG"],"primary_cat":"q-bio.QM","authors_text":"Austin Jin, Bryan Cheng","submitted_at":"2026-06-01T09:39:22Z","abstract_excerpt":"Proteolysis-targeting chimeras (PROTACs) can selectively degrade disease-causing proteins, yet predicting which targets are amenable to degradation remains a critical bottleneck: existing computational methods require the complete PROTAC molecular structure, information unavailable before synthesis. We present DegradoMap, a graph neural network that predicts PROTAC-mediated degradability from protein structure and E3 ligase identity alone -- the minimal information available at the target selection stage. The model encodes biophysical priors through lysine-weighted graph pooling with per-prote"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2606.04021","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2606.04021/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-06-04T00:06:44Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"YLDJEcSNraoTo6XULWYRBSoP0Y5ctxlKSA773+UTZDv+u37KBP0VaF27Sw0A7WxaSaTYsYJghif4RMNaya50BQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-11T08:26:52.996175Z"},"content_sha256":"97c24f8fc0a496c5f500828518425ec1a952e50482529bb5c9061804c7cdabf0","schema_version":"1.0","event_id":"sha256:97c24f8fc0a496c5f500828518425ec1a952e50482529bb5c9061804c7cdabf0"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/FLNUTXTW7AYI2I6DYRMIU5KV34/bundle.json","state_url":"https://pith.science/pith/FLNUTXTW7AYI2I6DYRMIU5KV34/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/FLNUTXTW7AYI2I6DYRMIU5KV34/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-11T08:26:52Z","links":{"resolver":"https://pith.science/pith/FLNUTXTW7AYI2I6DYRMIU5KV34","bundle":"https://pith.science/pith/FLNUTXTW7AYI2I6DYRMIU5KV34/bundle.json","state":"https://pith.science/pith/FLNUTXTW7AYI2I6DYRMIU5KV34/state.json","well_known_bundle":"https://pith.science/.well-known/pith/FLNUTXTW7AYI2I6DYRMIU5KV34/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2026:FLNUTXTW7AYI2I6DYRMIU5KV34","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"a677bc823d89f87c90fb6add6c16354a0c11c6cef04fe9c9999575f07bbfb015","cross_cats_sorted":["cs.LG"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2026-06-01T09:39:22Z","title_canon_sha256":"10c3faac0823f2585069d294fc9d0042feb0ee56740a98656d99fa5a6e5cc684"},"schema_version":"1.0","source":{"id":"2606.04021","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2606.04021","created_at":"2026-06-04T00:06:44Z"},{"alias_kind":"arxiv_version","alias_value":"2606.04021v1","created_at":"2026-06-04T00:06:44Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2606.04021","created_at":"2026-06-04T00:06:44Z"},{"alias_kind":"pith_short_12","alias_value":"FLNUTXTW7AYI","created_at":"2026-06-04T00:06:44Z"},{"alias_kind":"pith_short_16","alias_value":"FLNUTXTW7AYI2I6D","created_at":"2026-06-04T00:06:44Z"},{"alias_kind":"pith_short_8","alias_value":"FLNUTXTW","created_at":"2026-06-04T00:06:44Z"}],"graph_snapshots":[{"event_id":"sha256:97c24f8fc0a496c5f500828518425ec1a952e50482529bb5c9061804c7cdabf0","target":"graph","created_at":"2026-06-04T00:06:44Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2606.04021/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Proteolysis-targeting chimeras (PROTACs) can selectively degrade disease-causing proteins, yet predicting which targets are amenable to degradation remains a critical bottleneck: existing computational methods require the complete PROTAC molecular structure, information unavailable before synthesis. We present DegradoMap, a graph neural network that predicts PROTAC-mediated degradability from protein structure and E3 ligase identity alone -- the minimal information available at the target selection stage. The model encodes biophysical priors through lysine-weighted graph pooling with per-prote","authors_text":"Austin Jin, Bryan Cheng","cross_cats":["cs.LG"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2026-06-01T09:39:22Z","title":"Structure-Aware Prediction of PROTAC-Mediated Protein Degradability via Graph Neural Networks"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2606.04021","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:89616c0a1b26e5d390e154d0935090c16f144253c24b8c0d34b7c703d090bbad","target":"record","created_at":"2026-06-04T00:06:44Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"a677bc823d89f87c90fb6add6c16354a0c11c6cef04fe9c9999575f07bbfb015","cross_cats_sorted":["cs.LG"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2026-06-01T09:39:22Z","title_canon_sha256":"10c3faac0823f2585069d294fc9d0042feb0ee56740a98656d99fa5a6e5cc684"},"schema_version":"1.0","source":{"id":"2606.04021","kind":"arxiv","version":1}},"canonical_sha256":"2adb49de76f8308d23c3c4588a7555df27d91c14424da0a1caad3b2ccca1ee94","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"2adb49de76f8308d23c3c4588a7555df27d91c14424da0a1caad3b2ccca1ee94","first_computed_at":"2026-06-04T00:06:44.653047Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-06-04T00:06:44.653047Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"XOADmgUVzDz4WfSmbVfzrrUqoIsEVvOdOlDvjW0h21XkVQ7gNtUIAeYpFRF6q2/4z/CbwIABNa/HwFANkgvqBA==","signature_status":"signed_v1","signed_at":"2026-06-04T00:06:44.653477Z","signed_message":"canonical_sha256_bytes"},"source_id":"2606.04021","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:89616c0a1b26e5d390e154d0935090c16f144253c24b8c0d34b7c703d090bbad","sha256:97c24f8fc0a496c5f500828518425ec1a952e50482529bb5c9061804c7cdabf0"],"state_sha256":"44062cdf104d63506f39d25bb350607dfe97b9899b78f1c0191fb21cfaae8d3f"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"5JcaLJA+qbw/AY6JgCEehgo2xLhzXDPJOWEdFa0YX5HG8i+l4Z5LtgPqdDso74SHsl6mj5V61ug2bE3F1WKaCQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-11T08:26:53.000685Z","bundle_sha256":"c9203f6c1baf3255379de9314dc4f224e9b5b1bfe60c3a1bbdba17f62870b1b7"}}