{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2017:FN3UWGOTHAWWNCYKQPPMSPGNUV","short_pith_number":"pith:FN3UWGOT","canonical_record":{"source":{"id":"1704.06685","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2017-04-21T19:20:00Z","cross_cats_sorted":[],"title_canon_sha256":"588eca6bca813c660b3c231623743a8d13db500083bee17a57b2fb5b2c728ada","abstract_canon_sha256":"2370b2cb57e753c07affa43c491ac93945989d654e6a33243c09e7e6e31c32d6"},"schema_version":"1.0"},"canonical_sha256":"2b774b19d3382d668b0a83dec93ccda574fc88f29302d8ce1ef96db45a4047ea","source":{"kind":"arxiv","id":"1704.06685","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1704.06685","created_at":"2026-05-18T00:45:57Z"},{"alias_kind":"arxiv_version","alias_value":"1704.06685v1","created_at":"2026-05-18T00:45:57Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1704.06685","created_at":"2026-05-18T00:45:57Z"},{"alias_kind":"pith_short_12","alias_value":"FN3UWGOTHAWW","created_at":"2026-05-18T12:31:15Z"},{"alias_kind":"pith_short_16","alias_value":"FN3UWGOTHAWWNCYK","created_at":"2026-05-18T12:31:15Z"},{"alias_kind":"pith_short_8","alias_value":"FN3UWGOT","created_at":"2026-05-18T12:31:15Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2017:FN3UWGOTHAWWNCYKQPPMSPGNUV","target":"record","payload":{"canonical_record":{"source":{"id":"1704.06685","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2017-04-21T19:20:00Z","cross_cats_sorted":[],"title_canon_sha256":"588eca6bca813c660b3c231623743a8d13db500083bee17a57b2fb5b2c728ada","abstract_canon_sha256":"2370b2cb57e753c07affa43c491ac93945989d654e6a33243c09e7e6e31c32d6"},"schema_version":"1.0"},"canonical_sha256":"2b774b19d3382d668b0a83dec93ccda574fc88f29302d8ce1ef96db45a4047ea","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:45:57.899141Z","signature_b64":"qln3jaTq/ccKNebJO6QXFvOsq8nOpmHVCx+FSZJrizgVi0KlpZCIKKwzeiLYAr70FVBdc40/EMgINUCGg3PUBQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"2b774b19d3382d668b0a83dec93ccda574fc88f29302d8ce1ef96db45a4047ea","last_reissued_at":"2026-05-18T00:45:57.898647Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:45:57.898647Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1704.06685","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:45:57Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"iWtU0fJTpx9IeT7kLRMjg5dCpGCIMwIOU6rjnwwkAw5QeRkX4SzeFztUvDGxRVTGTneRkGH/ifbEoXSxWNKuDA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-28T04:07:03.868271Z"},"content_sha256":"26391a164712b0c90709d9e95ea7f3ccaea35997da3f78d037e46f2470cafbbb","schema_version":"1.0","event_id":"sha256:26391a164712b0c90709d9e95ea7f3ccaea35997da3f78d037e46f2470cafbbb"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2017:FN3UWGOTHAWWNCYKQPPMSPGNUV","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"A Continuum Poisson-Boltzmann Model for Membrane Channel Proteins","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"physics.bio-ph","authors_text":"D Artagnan Greene, Jianxiong Diao, Junmei Wang, Li Xiao, Ray Luo","submitted_at":"2017-04-21T19:20:00Z","abstract_excerpt":"Membrane proteins constitute a large portion of the human proteome and perform a variety of important functions as membrane receptors, transport proteins, enzymes, signaling proteins, and more. The computational studies of membrane proteins are usually much more complicated than those of globular proteins. Here we propose a new continuum model for Poisson-Boltzmann calculations of membrane channel proteins. Major improvements over the existing continuum slab model are as follows: 1) The location and thickness of the slab model are fine-tuned based on explicit-solvent MD simulations. 2) The hig"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1704.06685","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:45:57Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"AbArPNDxo+pJ31d//gcEmhDZOeLxVHRNb4X03r+qlnii4STzoQKEJHV5Jq6eOq4lmD+Nucm1GKSt06RTiOCcDw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-28T04:07:03.868632Z"},"content_sha256":"01963b868546df4156d92870640cc1743967b01220bea1675f91f0b6f0e4565a","schema_version":"1.0","event_id":"sha256:01963b868546df4156d92870640cc1743967b01220bea1675f91f0b6f0e4565a"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/FN3UWGOTHAWWNCYKQPPMSPGNUV/bundle.json","state_url":"https://pith.science/pith/FN3UWGOTHAWWNCYKQPPMSPGNUV/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/FN3UWGOTHAWWNCYKQPPMSPGNUV/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-28T04:07:03Z","links":{"resolver":"https://pith.science/pith/FN3UWGOTHAWWNCYKQPPMSPGNUV","bundle":"https://pith.science/pith/FN3UWGOTHAWWNCYKQPPMSPGNUV/bundle.json","state":"https://pith.science/pith/FN3UWGOTHAWWNCYKQPPMSPGNUV/state.json","well_known_bundle":"https://pith.science/.well-known/pith/FN3UWGOTHAWWNCYKQPPMSPGNUV/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2017:FN3UWGOTHAWWNCYKQPPMSPGNUV","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"2370b2cb57e753c07affa43c491ac93945989d654e6a33243c09e7e6e31c32d6","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2017-04-21T19:20:00Z","title_canon_sha256":"588eca6bca813c660b3c231623743a8d13db500083bee17a57b2fb5b2c728ada"},"schema_version":"1.0","source":{"id":"1704.06685","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1704.06685","created_at":"2026-05-18T00:45:57Z"},{"alias_kind":"arxiv_version","alias_value":"1704.06685v1","created_at":"2026-05-18T00:45:57Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1704.06685","created_at":"2026-05-18T00:45:57Z"},{"alias_kind":"pith_short_12","alias_value":"FN3UWGOTHAWW","created_at":"2026-05-18T12:31:15Z"},{"alias_kind":"pith_short_16","alias_value":"FN3UWGOTHAWWNCYK","created_at":"2026-05-18T12:31:15Z"},{"alias_kind":"pith_short_8","alias_value":"FN3UWGOT","created_at":"2026-05-18T12:31:15Z"}],"graph_snapshots":[{"event_id":"sha256:01963b868546df4156d92870640cc1743967b01220bea1675f91f0b6f0e4565a","target":"graph","created_at":"2026-05-18T00:45:57Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Membrane proteins constitute a large portion of the human proteome and perform a variety of important functions as membrane receptors, transport proteins, enzymes, signaling proteins, and more. The computational studies of membrane proteins are usually much more complicated than those of globular proteins. Here we propose a new continuum model for Poisson-Boltzmann calculations of membrane channel proteins. Major improvements over the existing continuum slab model are as follows: 1) The location and thickness of the slab model are fine-tuned based on explicit-solvent MD simulations. 2) The hig","authors_text":"D Artagnan Greene, Jianxiong Diao, Junmei Wang, Li Xiao, Ray Luo","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2017-04-21T19:20:00Z","title":"A Continuum Poisson-Boltzmann Model for Membrane Channel Proteins"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1704.06685","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:26391a164712b0c90709d9e95ea7f3ccaea35997da3f78d037e46f2470cafbbb","target":"record","created_at":"2026-05-18T00:45:57Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"2370b2cb57e753c07affa43c491ac93945989d654e6a33243c09e7e6e31c32d6","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2017-04-21T19:20:00Z","title_canon_sha256":"588eca6bca813c660b3c231623743a8d13db500083bee17a57b2fb5b2c728ada"},"schema_version":"1.0","source":{"id":"1704.06685","kind":"arxiv","version":1}},"canonical_sha256":"2b774b19d3382d668b0a83dec93ccda574fc88f29302d8ce1ef96db45a4047ea","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"2b774b19d3382d668b0a83dec93ccda574fc88f29302d8ce1ef96db45a4047ea","first_computed_at":"2026-05-18T00:45:57.898647Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:45:57.898647Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"qln3jaTq/ccKNebJO6QXFvOsq8nOpmHVCx+FSZJrizgVi0KlpZCIKKwzeiLYAr70FVBdc40/EMgINUCGg3PUBQ==","signature_status":"signed_v1","signed_at":"2026-05-18T00:45:57.899141Z","signed_message":"canonical_sha256_bytes"},"source_id":"1704.06685","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:26391a164712b0c90709d9e95ea7f3ccaea35997da3f78d037e46f2470cafbbb","sha256:01963b868546df4156d92870640cc1743967b01220bea1675f91f0b6f0e4565a"],"state_sha256":"44659ca22b658b0ac5c5f14db69d79b7cf5f8a5dab33661198c844f1448d018c"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Zq9STDqC2ikcVF702E50V8SDGU+StPNNw4UntPArlx26C3P6v76e0I4O7qx6Cyww2MemV1O+0UUfk2SuDho5Aw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-28T04:07:03.870571Z","bundle_sha256":"9be98176a87c5c4d59d9b2a1c38cacfe7ceb78729961b5a7c94485b3eb162e23"}}