{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2016:FVUCJ4DC2CFDAZCWIZBP2YQMAS","short_pith_number":"pith:FVUCJ4DC","schema_version":"1.0","canonical_sha256":"2d6824f062d08a3064564642fd620c04ad05b8ea93ed33adb33a3205ee649db2","source":{"kind":"arxiv","id":"1607.08444","version":1},"attestation_state":"computed","paper":{"title":"Cytomegalovirus Antigenic Mimicry of Human Alloreactive Peptides: A Potential Trigger for Graft versus Host Disease","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.GN","authors_text":"Abdelrhman Elnasseh, Allison Scalora, Amir Toor, Catherine Roberts, Charles Hall, Daniel Nixon, Gregory Buck, Jared Kobulnicky, Max Jameson-Lee, Micheal Neale, Myrna Serrano, Vishal Koparde","submitted_at":"2016-07-28T13:19:03Z","abstract_excerpt":"The association between human cytomegalovirus (hCMV) reactivation and the development of graft-versus-host-disease (GVHD) has been observed in stem cell transplantation (SCT). Seventy seven SCT donor-recipient pairs (DRP) (HLA matched unrelated donor (MUD), n=50; matched related donor (MRD), n=27) underwent whole exome sequencing to identify single nucleotide polymorphisms (SNPs) generating alloreactive peptide libraries for each DRP (9-mer peptide-HLA complexes); Human CMV CROSS (Cross-Reactive Open Source Sequence) Database was compiled from NCBI; HLA class I binding affinity for each DRPs H"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1607.08444","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2016-07-28T13:19:03Z","cross_cats_sorted":[],"title_canon_sha256":"c039d707c8d9f573d7c2bca618918b402928daa99aca0ae911e99bd2c93d364f","abstract_canon_sha256":"d54623fe421631fc8e80638d4864cb0e512d357810f93b1805b82700f0f99620"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:10:19.138036Z","signature_b64":"73UdwN/JLp0uIkOxdmWeGHCBpsOPoVfPVw+zpPkWNg69e4sEVegM1ZpIpRwoh5kfSiGx/h7VZVbkOZaz8kfJBg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"2d6824f062d08a3064564642fd620c04ad05b8ea93ed33adb33a3205ee649db2","last_reissued_at":"2026-05-18T01:10:19.137514Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:10:19.137514Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Cytomegalovirus Antigenic Mimicry of Human Alloreactive Peptides: A Potential Trigger for Graft versus Host Disease","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.GN","authors_text":"Abdelrhman Elnasseh, Allison Scalora, Amir Toor, Catherine Roberts, Charles Hall, Daniel Nixon, Gregory Buck, Jared Kobulnicky, Max Jameson-Lee, Micheal Neale, Myrna Serrano, Vishal Koparde","submitted_at":"2016-07-28T13:19:03Z","abstract_excerpt":"The association between human cytomegalovirus (hCMV) reactivation and the development of graft-versus-host-disease (GVHD) has been observed in stem cell transplantation (SCT). Seventy seven SCT donor-recipient pairs (DRP) (HLA matched unrelated donor (MUD), n=50; matched related donor (MRD), n=27) underwent whole exome sequencing to identify single nucleotide polymorphisms (SNPs) generating alloreactive peptide libraries for each DRP (9-mer peptide-HLA complexes); Human CMV CROSS (Cross-Reactive Open Source Sequence) Database was compiled from NCBI; HLA class I binding affinity for each DRPs H"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1607.08444","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1607.08444","created_at":"2026-05-18T01:10:19.137591+00:00"},{"alias_kind":"arxiv_version","alias_value":"1607.08444v1","created_at":"2026-05-18T01:10:19.137591+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1607.08444","created_at":"2026-05-18T01:10:19.137591+00:00"},{"alias_kind":"pith_short_12","alias_value":"FVUCJ4DC2CFD","created_at":"2026-05-18T12:30:15.759754+00:00"},{"alias_kind":"pith_short_16","alias_value":"FVUCJ4DC2CFDAZCW","created_at":"2026-05-18T12:30:15.759754+00:00"},{"alias_kind":"pith_short_8","alias_value":"FVUCJ4DC","created_at":"2026-05-18T12:30:15.759754+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/FVUCJ4DC2CFDAZCWIZBP2YQMAS","json":"https://pith.science/pith/FVUCJ4DC2CFDAZCWIZBP2YQMAS.json","graph_json":"https://pith.science/api/pith-number/FVUCJ4DC2CFDAZCWIZBP2YQMAS/graph.json","events_json":"https://pith.science/api/pith-number/FVUCJ4DC2CFDAZCWIZBP2YQMAS/events.json","paper":"https://pith.science/paper/FVUCJ4DC"},"agent_actions":{"view_html":"https://pith.science/pith/FVUCJ4DC2CFDAZCWIZBP2YQMAS","download_json":"https://pith.science/pith/FVUCJ4DC2CFDAZCWIZBP2YQMAS.json","view_paper":"https://pith.science/paper/FVUCJ4DC","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1607.08444&json=true","fetch_graph":"https://pith.science/api/pith-number/FVUCJ4DC2CFDAZCWIZBP2YQMAS/graph.json","fetch_events":"https://pith.science/api/pith-number/FVUCJ4DC2CFDAZCWIZBP2YQMAS/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/FVUCJ4DC2CFDAZCWIZBP2YQMAS/action/timestamp_anchor","attest_storage":"https://pith.science/pith/FVUCJ4DC2CFDAZCWIZBP2YQMAS/action/storage_attestation","attest_author":"https://pith.science/pith/FVUCJ4DC2CFDAZCWIZBP2YQMAS/action/author_attestation","sign_citation":"https://pith.science/pith/FVUCJ4DC2CFDAZCWIZBP2YQMAS/action/citation_signature","submit_replication":"https://pith.science/pith/FVUCJ4DC2CFDAZCWIZBP2YQMAS/action/replication_record"}},"created_at":"2026-05-18T01:10:19.137591+00:00","updated_at":"2026-05-18T01:10:19.137591+00:00"}