{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2016:FVZNBXTDSA2SFRQ7I4LTIRQNUW","short_pith_number":"pith:FVZNBXTD","canonical_record":{"source":{"id":"1611.04473","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2016-11-14T17:03:45Z","cross_cats_sorted":[],"title_canon_sha256":"d3621ab614fef2ff25b376fd62a0fc2ed430f983613b6c2e142488d7516fcb7b","abstract_canon_sha256":"9cde270b63955c4dd881a4fae438583d8986f791846e06ddcea4cb98aa59292c"},"schema_version":"1.0"},"canonical_sha256":"2d72d0de63903522c61f471734460da5ad0580c7f420c39a63ea3f8f3680d847","source":{"kind":"arxiv","id":"1611.04473","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1611.04473","created_at":"2026-05-18T00:59:16Z"},{"alias_kind":"arxiv_version","alias_value":"1611.04473v1","created_at":"2026-05-18T00:59:16Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1611.04473","created_at":"2026-05-18T00:59:16Z"},{"alias_kind":"pith_short_12","alias_value":"FVZNBXTDSA2S","created_at":"2026-05-18T12:30:15Z"},{"alias_kind":"pith_short_16","alias_value":"FVZNBXTDSA2SFRQ7","created_at":"2026-05-18T12:30:15Z"},{"alias_kind":"pith_short_8","alias_value":"FVZNBXTD","created_at":"2026-05-18T12:30:15Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2016:FVZNBXTDSA2SFRQ7I4LTIRQNUW","target":"record","payload":{"canonical_record":{"source":{"id":"1611.04473","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2016-11-14T17:03:45Z","cross_cats_sorted":[],"title_canon_sha256":"d3621ab614fef2ff25b376fd62a0fc2ed430f983613b6c2e142488d7516fcb7b","abstract_canon_sha256":"9cde270b63955c4dd881a4fae438583d8986f791846e06ddcea4cb98aa59292c"},"schema_version":"1.0"},"canonical_sha256":"2d72d0de63903522c61f471734460da5ad0580c7f420c39a63ea3f8f3680d847","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:59:16.497836Z","signature_b64":"t6izV51NUeo37onHEQNRSk9SvVcf7soHtqs16LeB+wyaknR21AA/tj1CfBoKsoGLbD1elWHdvL2I+SuEf0+ADA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"2d72d0de63903522c61f471734460da5ad0580c7f420c39a63ea3f8f3680d847","last_reissued_at":"2026-05-18T00:59:16.497455Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:59:16.497455Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1611.04473","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:59:16Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"27s8ga00VMkovAkhTeUFHZrSHiQuhkgf0dCUNJmIaRV9/8D/ShsOg6hGOZL2WgeBHrDu7sh+/y5vq4cOveHCDg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-04T07:17:10.720481Z"},"content_sha256":"0839fecf1ddc892e857b68b9f821d589a776e287a0f9ff49e76387db67f97e57","schema_version":"1.0","event_id":"sha256:0839fecf1ddc892e857b68b9f821d589a776e287a0f9ff49e76387db67f97e57"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2016:FVZNBXTDSA2SFRQ7I4LTIRQNUW","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Simultaneous detection and estimation of trait associations with genomic phenotypes","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"stat.ME","authors_text":"Daniela Witten, Jean Morrison, Noah Simon","submitted_at":"2016-11-14T17:03:45Z","abstract_excerpt":"Genomic phenotypes, such as DNA methylation and chromatin accessibility, can be used to characterize the transcriptional and regulatory activity of DNA within a cell. Recent technological advances have made it possible to measure such phenotypes very densely. This density often results in spatial structure, in the sense that measurements at nearby sites are very similar.\n  In this paper, we consider the task of comparing genomic phenotypes across experimental conditions, cell types, or disease subgroups. We propose a new method, Joint Adaptive Differential Estimation (JADE), which leverages th"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1611.04473","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:59:16Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"hGeeKELF+MXcBTxN/0Fa6ec2GvpJLetlgr+Af2lRu5dfAjIlWHLKfEaqrTWdjgCXe32M2WLqswRP4MEi1ArkAw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-04T07:17:10.720835Z"},"content_sha256":"cb105ec4a62683c6e18ad020223bb553a320d0bf1257d59434a56d328b14ad2e","schema_version":"1.0","event_id":"sha256:cb105ec4a62683c6e18ad020223bb553a320d0bf1257d59434a56d328b14ad2e"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/FVZNBXTDSA2SFRQ7I4LTIRQNUW/bundle.json","state_url":"https://pith.science/pith/FVZNBXTDSA2SFRQ7I4LTIRQNUW/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/FVZNBXTDSA2SFRQ7I4LTIRQNUW/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-04T07:17:10Z","links":{"resolver":"https://pith.science/pith/FVZNBXTDSA2SFRQ7I4LTIRQNUW","bundle":"https://pith.science/pith/FVZNBXTDSA2SFRQ7I4LTIRQNUW/bundle.json","state":"https://pith.science/pith/FVZNBXTDSA2SFRQ7I4LTIRQNUW/state.json","well_known_bundle":"https://pith.science/.well-known/pith/FVZNBXTDSA2SFRQ7I4LTIRQNUW/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2016:FVZNBXTDSA2SFRQ7I4LTIRQNUW","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"9cde270b63955c4dd881a4fae438583d8986f791846e06ddcea4cb98aa59292c","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2016-11-14T17:03:45Z","title_canon_sha256":"d3621ab614fef2ff25b376fd62a0fc2ed430f983613b6c2e142488d7516fcb7b"},"schema_version":"1.0","source":{"id":"1611.04473","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1611.04473","created_at":"2026-05-18T00:59:16Z"},{"alias_kind":"arxiv_version","alias_value":"1611.04473v1","created_at":"2026-05-18T00:59:16Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1611.04473","created_at":"2026-05-18T00:59:16Z"},{"alias_kind":"pith_short_12","alias_value":"FVZNBXTDSA2S","created_at":"2026-05-18T12:30:15Z"},{"alias_kind":"pith_short_16","alias_value":"FVZNBXTDSA2SFRQ7","created_at":"2026-05-18T12:30:15Z"},{"alias_kind":"pith_short_8","alias_value":"FVZNBXTD","created_at":"2026-05-18T12:30:15Z"}],"graph_snapshots":[{"event_id":"sha256:cb105ec4a62683c6e18ad020223bb553a320d0bf1257d59434a56d328b14ad2e","target":"graph","created_at":"2026-05-18T00:59:16Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Genomic phenotypes, such as DNA methylation and chromatin accessibility, can be used to characterize the transcriptional and regulatory activity of DNA within a cell. Recent technological advances have made it possible to measure such phenotypes very densely. This density often results in spatial structure, in the sense that measurements at nearby sites are very similar.\n  In this paper, we consider the task of comparing genomic phenotypes across experimental conditions, cell types, or disease subgroups. We propose a new method, Joint Adaptive Differential Estimation (JADE), which leverages th","authors_text":"Daniela Witten, Jean Morrison, Noah Simon","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2016-11-14T17:03:45Z","title":"Simultaneous detection and estimation of trait associations with genomic phenotypes"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1611.04473","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:0839fecf1ddc892e857b68b9f821d589a776e287a0f9ff49e76387db67f97e57","target":"record","created_at":"2026-05-18T00:59:16Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"9cde270b63955c4dd881a4fae438583d8986f791846e06ddcea4cb98aa59292c","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"stat.ME","submitted_at":"2016-11-14T17:03:45Z","title_canon_sha256":"d3621ab614fef2ff25b376fd62a0fc2ed430f983613b6c2e142488d7516fcb7b"},"schema_version":"1.0","source":{"id":"1611.04473","kind":"arxiv","version":1}},"canonical_sha256":"2d72d0de63903522c61f471734460da5ad0580c7f420c39a63ea3f8f3680d847","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"2d72d0de63903522c61f471734460da5ad0580c7f420c39a63ea3f8f3680d847","first_computed_at":"2026-05-18T00:59:16.497455Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:59:16.497455Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"t6izV51NUeo37onHEQNRSk9SvVcf7soHtqs16LeB+wyaknR21AA/tj1CfBoKsoGLbD1elWHdvL2I+SuEf0+ADA==","signature_status":"signed_v1","signed_at":"2026-05-18T00:59:16.497836Z","signed_message":"canonical_sha256_bytes"},"source_id":"1611.04473","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:0839fecf1ddc892e857b68b9f821d589a776e287a0f9ff49e76387db67f97e57","sha256:cb105ec4a62683c6e18ad020223bb553a320d0bf1257d59434a56d328b14ad2e"],"state_sha256":"18f6260e3a8382764e4901920be47e9dc3e355dface39e709e4f3ce175a720a3"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"d+7tb2TqY+ZtdPbb4EpA/7acNFqM5RzxKMu13vUlsOB6PNDzPIYNT0FNOG3ndatjnb65D9C4b1GwIo2+zDEVDw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-04T07:17:10.723000Z","bundle_sha256":"61f3f08080bb841851c0ad3452997829c3a0e40d1c07ec4a37a243df95347e19"}}