{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2010:FWTCKHGVYAPE6FIB7Z7MT3UGBO","short_pith_number":"pith:FWTCKHGV","canonical_record":{"source":{"id":"1005.4342","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2010-05-24T14:49:37Z","cross_cats_sorted":["q-bio.MN"],"title_canon_sha256":"2602605726fd1a17950bc71f09629535979186d53e80a5b89b13267ac1c9b05f","abstract_canon_sha256":"4213d7dc5eac1dc1faf9a0349fac13f03074f83c43229db424cf701ff302bca8"},"schema_version":"1.0"},"canonical_sha256":"2da6251cd5c01e4f1501fe7ec9ee860ba3c45c992052b85aa0db7f395f22b874","source":{"kind":"arxiv","id":"1005.4342","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1005.4342","created_at":"2026-05-18T03:14:30Z"},{"alias_kind":"arxiv_version","alias_value":"1005.4342v1","created_at":"2026-05-18T03:14:30Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1005.4342","created_at":"2026-05-18T03:14:30Z"},{"alias_kind":"pith_short_12","alias_value":"FWTCKHGVYAPE","created_at":"2026-05-18T12:26:07Z"},{"alias_kind":"pith_short_16","alias_value":"FWTCKHGVYAPE6FIB","created_at":"2026-05-18T12:26:07Z"},{"alias_kind":"pith_short_8","alias_value":"FWTCKHGV","created_at":"2026-05-18T12:26:07Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2010:FWTCKHGVYAPE6FIB7Z7MT3UGBO","target":"record","payload":{"canonical_record":{"source":{"id":"1005.4342","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2010-05-24T14:49:37Z","cross_cats_sorted":["q-bio.MN"],"title_canon_sha256":"2602605726fd1a17950bc71f09629535979186d53e80a5b89b13267ac1c9b05f","abstract_canon_sha256":"4213d7dc5eac1dc1faf9a0349fac13f03074f83c43229db424cf701ff302bca8"},"schema_version":"1.0"},"canonical_sha256":"2da6251cd5c01e4f1501fe7ec9ee860ba3c45c992052b85aa0db7f395f22b874","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T03:14:30.699921Z","signature_b64":"XBpn7iGbj8IclHKsewl030hkPyVdrJfsyIPh7PHBzcNXaxMS6RKHp1TsNqJF3iHAzH62PBllY2phnQjAf8NXAA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"2da6251cd5c01e4f1501fe7ec9ee860ba3c45c992052b85aa0db7f395f22b874","last_reissued_at":"2026-05-18T03:14:30.699132Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T03:14:30.699132Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1005.4342","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:14:30Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"2syK7oRGcLzhtO8OkdCU75yeqxUqc9/D0h8FTBGMcVCKpYk15+eoXj4PFke7xePA4BxMGKbRJo0QrZFGWif4Cg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-28T21:22:11.551243Z"},"content_sha256":"2e0b992839ae46f5e9f5951bfe116e86343eedb8161541df84fb39b384480df0","schema_version":"1.0","event_id":"sha256:2e0b992839ae46f5e9f5951bfe116e86343eedb8161541df84fb39b384480df0"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2010:FWTCKHGVYAPE6FIB7Z7MT3UGBO","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"The effect of scale-free topology on the robustness and evolvability of genetic regulatory networks","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.MN"],"primary_cat":"q-bio.PE","authors_text":"Ard A. Louis, Iain G. Johnston, Jonathan P. K. Doye, Matthew A. Smith, Sam F. Greenbury","submitted_at":"2010-05-24T14:49:37Z","abstract_excerpt":"We investigate how scale-free (SF) and Erdos-Renyi (ER) topologies affect the interplay between evolvability and robustness of model gene regulatory networks with Boolean threshold dynamics. In agreement with Oikonomou and Cluzel (2006) we find that networks with SFin topologies, that is SF topology for incoming nodes and ER topology for outgoing nodes, are significantly more evolvable towards specific oscillatory targets than networks with ER topology for both incoming and outgoing nodes. Similar results are found for networks with SFboth and SFout topologies. The functionality of the SFout t"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1005.4342","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:14:30Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"kQvvBx+hWaLyxGMrZe6qyF5i7v9M/7gmcQokWfNSr2RnAN7YvdKxKxr/5/j7rpOgmABzjC7ZZZWvopOsnvmoDg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-28T21:22:11.551956Z"},"content_sha256":"5729f8aeaf99b1200087f0c6e5b84b46ab2f25d99d77cae19d56d96c18e97e97","schema_version":"1.0","event_id":"sha256:5729f8aeaf99b1200087f0c6e5b84b46ab2f25d99d77cae19d56d96c18e97e97"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/FWTCKHGVYAPE6FIB7Z7MT3UGBO/bundle.json","state_url":"https://pith.science/pith/FWTCKHGVYAPE6FIB7Z7MT3UGBO/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/FWTCKHGVYAPE6FIB7Z7MT3UGBO/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-28T21:22:11Z","links":{"resolver":"https://pith.science/pith/FWTCKHGVYAPE6FIB7Z7MT3UGBO","bundle":"https://pith.science/pith/FWTCKHGVYAPE6FIB7Z7MT3UGBO/bundle.json","state":"https://pith.science/pith/FWTCKHGVYAPE6FIB7Z7MT3UGBO/state.json","well_known_bundle":"https://pith.science/.well-known/pith/FWTCKHGVYAPE6FIB7Z7MT3UGBO/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2010:FWTCKHGVYAPE6FIB7Z7MT3UGBO","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"4213d7dc5eac1dc1faf9a0349fac13f03074f83c43229db424cf701ff302bca8","cross_cats_sorted":["q-bio.MN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2010-05-24T14:49:37Z","title_canon_sha256":"2602605726fd1a17950bc71f09629535979186d53e80a5b89b13267ac1c9b05f"},"schema_version":"1.0","source":{"id":"1005.4342","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1005.4342","created_at":"2026-05-18T03:14:30Z"},{"alias_kind":"arxiv_version","alias_value":"1005.4342v1","created_at":"2026-05-18T03:14:30Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1005.4342","created_at":"2026-05-18T03:14:30Z"},{"alias_kind":"pith_short_12","alias_value":"FWTCKHGVYAPE","created_at":"2026-05-18T12:26:07Z"},{"alias_kind":"pith_short_16","alias_value":"FWTCKHGVYAPE6FIB","created_at":"2026-05-18T12:26:07Z"},{"alias_kind":"pith_short_8","alias_value":"FWTCKHGV","created_at":"2026-05-18T12:26:07Z"}],"graph_snapshots":[{"event_id":"sha256:5729f8aeaf99b1200087f0c6e5b84b46ab2f25d99d77cae19d56d96c18e97e97","target":"graph","created_at":"2026-05-18T03:14:30Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"We investigate how scale-free (SF) and Erdos-Renyi (ER) topologies affect the interplay between evolvability and robustness of model gene regulatory networks with Boolean threshold dynamics. In agreement with Oikonomou and Cluzel (2006) we find that networks with SFin topologies, that is SF topology for incoming nodes and ER topology for outgoing nodes, are significantly more evolvable towards specific oscillatory targets than networks with ER topology for both incoming and outgoing nodes. Similar results are found for networks with SFboth and SFout topologies. The functionality of the SFout t","authors_text":"Ard A. Louis, Iain G. Johnston, Jonathan P. K. Doye, Matthew A. Smith, Sam F. Greenbury","cross_cats":["q-bio.MN"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2010-05-24T14:49:37Z","title":"The effect of scale-free topology on the robustness and evolvability of genetic regulatory networks"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1005.4342","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:2e0b992839ae46f5e9f5951bfe116e86343eedb8161541df84fb39b384480df0","target":"record","created_at":"2026-05-18T03:14:30Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"4213d7dc5eac1dc1faf9a0349fac13f03074f83c43229db424cf701ff302bca8","cross_cats_sorted":["q-bio.MN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2010-05-24T14:49:37Z","title_canon_sha256":"2602605726fd1a17950bc71f09629535979186d53e80a5b89b13267ac1c9b05f"},"schema_version":"1.0","source":{"id":"1005.4342","kind":"arxiv","version":1}},"canonical_sha256":"2da6251cd5c01e4f1501fe7ec9ee860ba3c45c992052b85aa0db7f395f22b874","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"2da6251cd5c01e4f1501fe7ec9ee860ba3c45c992052b85aa0db7f395f22b874","first_computed_at":"2026-05-18T03:14:30.699132Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T03:14:30.699132Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"XBpn7iGbj8IclHKsewl030hkPyVdrJfsyIPh7PHBzcNXaxMS6RKHp1TsNqJF3iHAzH62PBllY2phnQjAf8NXAA==","signature_status":"signed_v1","signed_at":"2026-05-18T03:14:30.699921Z","signed_message":"canonical_sha256_bytes"},"source_id":"1005.4342","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:2e0b992839ae46f5e9f5951bfe116e86343eedb8161541df84fb39b384480df0","sha256:5729f8aeaf99b1200087f0c6e5b84b46ab2f25d99d77cae19d56d96c18e97e97"],"state_sha256":"a52012458f1c8319eecc334c8905ae11e5803b4eb98b161d089f7fadda627119"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"sCR46xuko7KU+vJ2wxTZiiCw8ngVfj9P1/maFo6ZUdNDcRD78wfugzbFhe09iGhMj30zHAZs6hX8Y8iSkFOVBA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-28T21:22:11.555045Z","bundle_sha256":"c6f4ff226b0458946a22779ce098315dba16ff7a84ca238c2de864b81b6101d4"}}