{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2013:FXKITSTMR4JLLGL5ZHWXEDBDCR","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"c495272d96d71b16478d39310bf2e26131a0dbec43f8f4d57f4a2b05ea02951c","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2013-09-03T13:37:47Z","title_canon_sha256":"34e0b181402b36b5a224b3080da048b6141e86fe41c7aa61f5b384199c1009e6"},"schema_version":"1.0","source":{"id":"1309.0670","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1309.0670","created_at":"2026-05-18T03:14:16Z"},{"alias_kind":"arxiv_version","alias_value":"1309.0670v2","created_at":"2026-05-18T03:14:16Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1309.0670","created_at":"2026-05-18T03:14:16Z"},{"alias_kind":"pith_short_12","alias_value":"FXKITSTMR4JL","created_at":"2026-05-18T12:27:45Z"},{"alias_kind":"pith_short_16","alias_value":"FXKITSTMR4JLLGL5","created_at":"2026-05-18T12:27:45Z"},{"alias_kind":"pith_short_8","alias_value":"FXKITSTM","created_at":"2026-05-18T12:27:45Z"}],"graph_snapshots":[{"event_id":"sha256:44ed19f5c724ec9bd7e03843cff6afde140b41b324c823b05d353bb49eef36cb","target":"graph","created_at":"2026-05-18T03:14:16Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"RNA-seq has become a de facto standard for measuring gene expression. Traditionally, RNA-seq experiments are mathematically averaged -- they sequence the mRNA of individuals from different treatment groups, hoping to correlate phenotype with differences in arithmetic read count averages at shared loci of interest. Alternatively, the tissue from the same individuals may be pooled prior to sequencing in what we refer to as a biologically averaged design. As mathematical averaging sequences all individuals it controls for both biological and technical variation; however, is the statistical resolu","authors_text":"Corbin D. Jones, Jeffery L. Dangl, Surojit Biswas, Tatiana S. Mucyn, Yash N. Agrawal","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2013-09-03T13:37:47Z","title":"Biological Averaging in RNA-Seq"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1309.0670","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:2435743fc5b9d0a7490838d1b4175d7a69abb89e9c1bef201b53e1abc6327e68","target":"record","created_at":"2026-05-18T03:14:16Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"c495272d96d71b16478d39310bf2e26131a0dbec43f8f4d57f4a2b05ea02951c","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2013-09-03T13:37:47Z","title_canon_sha256":"34e0b181402b36b5a224b3080da048b6141e86fe41c7aa61f5b384199c1009e6"},"schema_version":"1.0","source":{"id":"1309.0670","kind":"arxiv","version":2}},"canonical_sha256":"2dd489ca6c8f12b5997dc9ed720c231441e2d1560e85d2d4f7f96acf70c3e4bf","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"2dd489ca6c8f12b5997dc9ed720c231441e2d1560e85d2d4f7f96acf70c3e4bf","first_computed_at":"2026-05-18T03:14:16.844079Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T03:14:16.844079Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"RFodmjy/pESWd9AmCxNOQxTIdBAaL5xnDkKGhUw1XxgUT3+7XT9zEXQwItk8v/3hzezOHZmc9LgMVsk3EbxdCQ==","signature_status":"signed_v1","signed_at":"2026-05-18T03:14:16.844691Z","signed_message":"canonical_sha256_bytes"},"source_id":"1309.0670","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:2435743fc5b9d0a7490838d1b4175d7a69abb89e9c1bef201b53e1abc6327e68","sha256:44ed19f5c724ec9bd7e03843cff6afde140b41b324c823b05d353bb49eef36cb"],"state_sha256":"95bdb6fabcf48abc2d82832069073353302364204b72ae015910deb5f724dda6"}