{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2025:FZH7Y6MFPZQEG6GPASQNSZUMPJ","short_pith_number":"pith:FZH7Y6MF","canonical_record":{"source":{"id":"2506.24013","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"stat.ME","submitted_at":"2025-06-30T16:18:06Z","cross_cats_sorted":["q-bio.GN","stat.AP"],"title_canon_sha256":"29b94785d75fe52695d8de32adcb5044f8d77f601335dd9c1d8a431e6e43c43c","abstract_canon_sha256":"15544e84e441d9d9e0488bdf2d3136f0a2dbe19bfa3cbeba5c55886658c90819"},"schema_version":"1.0"},"canonical_sha256":"2e4ffc79857e604378cf04a0d9668c7a671e2684d0cf655a3584fb92dc929747","source":{"kind":"arxiv","id":"2506.24013","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2506.24013","created_at":"2026-07-05T11:29:31Z"},{"alias_kind":"arxiv_version","alias_value":"2506.24013v1","created_at":"2026-07-05T11:29:31Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2506.24013","created_at":"2026-07-05T11:29:31Z"},{"alias_kind":"pith_short_12","alias_value":"FZH7Y6MFPZQE","created_at":"2026-07-05T11:29:31Z"},{"alias_kind":"pith_short_16","alias_value":"FZH7Y6MFPZQEG6GP","created_at":"2026-07-05T11:29:31Z"},{"alias_kind":"pith_short_8","alias_value":"FZH7Y6MF","created_at":"2026-07-05T11:29:31Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2025:FZH7Y6MFPZQEG6GPASQNSZUMPJ","target":"record","payload":{"canonical_record":{"source":{"id":"2506.24013","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"stat.ME","submitted_at":"2025-06-30T16:18:06Z","cross_cats_sorted":["q-bio.GN","stat.AP"],"title_canon_sha256":"29b94785d75fe52695d8de32adcb5044f8d77f601335dd9c1d8a431e6e43c43c","abstract_canon_sha256":"15544e84e441d9d9e0488bdf2d3136f0a2dbe19bfa3cbeba5c55886658c90819"},"schema_version":"1.0"},"canonical_sha256":"2e4ffc79857e604378cf04a0d9668c7a671e2684d0cf655a3584fb92dc929747","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T11:29:31.682455Z","signature_b64":"mL4YEoyIKBXG7C7bnToTy8KaolhpXUNST/dCS/fR8Mkt+XXhaJdHDGZCX/TUIGbFUqaVg/dwVIiGhmwRyFzhAw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"2e4ffc79857e604378cf04a0d9668c7a671e2684d0cf655a3584fb92dc929747","last_reissued_at":"2026-07-05T11:29:31.681989Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T11:29:31.681989Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2506.24013","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T11:29:31Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"URb4Z60aIV5C1H1teheg33g1BW8vPIZ4XBfsonB/Xqu3q5VzxQtr0EYcEAshR2brBkG3WcmNrMfDzX2PTOHxBQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-15T23:36:30.134210Z"},"content_sha256":"d263d727a05ccd438224ba6eb34a805e8b289b128f6ed3c72decb8ac544bd5d0","schema_version":"1.0","event_id":"sha256:d263d727a05ccd438224ba6eb34a805e8b289b128f6ed3c72decb8ac544bd5d0"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2025:FZH7Y6MFPZQEG6GPASQNSZUMPJ","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"CoMMiT: Co-informed inference of microbiome-metabolome interactions via transfer learning","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["q-bio.GN","stat.AP"],"primary_cat":"stat.ME","authors_text":"Chenglong Ye, Daniel Raftery, Johanna Lampe, Leiyue Li, Marian Neuhouser, Meredith Hullar, Tim Randolph, Yue Wang","submitted_at":"2025-06-30T16:18:06Z","abstract_excerpt":"Recent multi-omic microbiome studies enable integrative analysis of microbes and metabolites, uncovering their associations with various host conditions. Such analyses require multivariate models capable of accounting for the complex correlation structures between microbes and metabolites. However, existing multivariate models often suffer from low statistical power for detecting microbiome-metabolome interactions due to small sample sizes and weak biological signals. To address these challenges, we introduce CoMMiT, Co-informed inference of Microbiome-Metabolome Interactions via novel Transfe"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2506.24013","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2506.24013/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T11:29:31Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"nppvcDz1chjlKyQcIBVgWmoTKEwgoGsYy+jFfJh2SOzc/+5DxsBwriiz6sGjjzDv5Ujq/idedowHc15eGaCjBg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-15T23:36:30.134729Z"},"content_sha256":"28103ebd73a2f290328c3c589eced8b1bf90150570c77ba319145aa62002cbb1","schema_version":"1.0","event_id":"sha256:28103ebd73a2f290328c3c589eced8b1bf90150570c77ba319145aa62002cbb1"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/FZH7Y6MFPZQEG6GPASQNSZUMPJ/bundle.json","state_url":"https://pith.science/pith/FZH7Y6MFPZQEG6GPASQNSZUMPJ/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/FZH7Y6MFPZQEG6GPASQNSZUMPJ/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-15T23:36:30Z","links":{"resolver":"https://pith.science/pith/FZH7Y6MFPZQEG6GPASQNSZUMPJ","bundle":"https://pith.science/pith/FZH7Y6MFPZQEG6GPASQNSZUMPJ/bundle.json","state":"https://pith.science/pith/FZH7Y6MFPZQEG6GPASQNSZUMPJ/state.json","well_known_bundle":"https://pith.science/.well-known/pith/FZH7Y6MFPZQEG6GPASQNSZUMPJ/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:FZH7Y6MFPZQEG6GPASQNSZUMPJ","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"15544e84e441d9d9e0488bdf2d3136f0a2dbe19bfa3cbeba5c55886658c90819","cross_cats_sorted":["q-bio.GN","stat.AP"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"stat.ME","submitted_at":"2025-06-30T16:18:06Z","title_canon_sha256":"29b94785d75fe52695d8de32adcb5044f8d77f601335dd9c1d8a431e6e43c43c"},"schema_version":"1.0","source":{"id":"2506.24013","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2506.24013","created_at":"2026-07-05T11:29:31Z"},{"alias_kind":"arxiv_version","alias_value":"2506.24013v1","created_at":"2026-07-05T11:29:31Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2506.24013","created_at":"2026-07-05T11:29:31Z"},{"alias_kind":"pith_short_12","alias_value":"FZH7Y6MFPZQE","created_at":"2026-07-05T11:29:31Z"},{"alias_kind":"pith_short_16","alias_value":"FZH7Y6MFPZQEG6GP","created_at":"2026-07-05T11:29:31Z"},{"alias_kind":"pith_short_8","alias_value":"FZH7Y6MF","created_at":"2026-07-05T11:29:31Z"}],"graph_snapshots":[{"event_id":"sha256:28103ebd73a2f290328c3c589eced8b1bf90150570c77ba319145aa62002cbb1","target":"graph","created_at":"2026-07-05T11:29:31Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2506.24013/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Recent multi-omic microbiome studies enable integrative analysis of microbes and metabolites, uncovering their associations with various host conditions. Such analyses require multivariate models capable of accounting for the complex correlation structures between microbes and metabolites. However, existing multivariate models often suffer from low statistical power for detecting microbiome-metabolome interactions due to small sample sizes and weak biological signals. To address these challenges, we introduce CoMMiT, Co-informed inference of Microbiome-Metabolome Interactions via novel Transfe","authors_text":"Chenglong Ye, Daniel Raftery, Johanna Lampe, Leiyue Li, Marian Neuhouser, Meredith Hullar, Tim Randolph, Yue Wang","cross_cats":["q-bio.GN","stat.AP"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"stat.ME","submitted_at":"2025-06-30T16:18:06Z","title":"CoMMiT: Co-informed inference of microbiome-metabolome interactions via transfer learning"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2506.24013","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:d263d727a05ccd438224ba6eb34a805e8b289b128f6ed3c72decb8ac544bd5d0","target":"record","created_at":"2026-07-05T11:29:31Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"15544e84e441d9d9e0488bdf2d3136f0a2dbe19bfa3cbeba5c55886658c90819","cross_cats_sorted":["q-bio.GN","stat.AP"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"stat.ME","submitted_at":"2025-06-30T16:18:06Z","title_canon_sha256":"29b94785d75fe52695d8de32adcb5044f8d77f601335dd9c1d8a431e6e43c43c"},"schema_version":"1.0","source":{"id":"2506.24013","kind":"arxiv","version":1}},"canonical_sha256":"2e4ffc79857e604378cf04a0d9668c7a671e2684d0cf655a3584fb92dc929747","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"2e4ffc79857e604378cf04a0d9668c7a671e2684d0cf655a3584fb92dc929747","first_computed_at":"2026-07-05T11:29:31.681989Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T11:29:31.681989Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"mL4YEoyIKBXG7C7bnToTy8KaolhpXUNST/dCS/fR8Mkt+XXhaJdHDGZCX/TUIGbFUqaVg/dwVIiGhmwRyFzhAw==","signature_status":"signed_v1","signed_at":"2026-07-05T11:29:31.682455Z","signed_message":"canonical_sha256_bytes"},"source_id":"2506.24013","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:d263d727a05ccd438224ba6eb34a805e8b289b128f6ed3c72decb8ac544bd5d0","sha256:28103ebd73a2f290328c3c589eced8b1bf90150570c77ba319145aa62002cbb1"],"state_sha256":"30723c6fb5b94de75920e817cefe082d2d37d338ae7c088ebea5c347ef167c6c"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"gHHGGyBH5fC7Wvw9lrAAzp8tzAQWVOW7eedaZMXeHiWgKRZScRGebJG3vjrzTSmoL2Qoe7lfECB1M4DHz8qhDg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-15T23:36:30.138160Z","bundle_sha256":"5d67c462584d8a0adcb190f7acbeea825cc815f0ef5e56f7d905707e3fed8572"}}