{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2021:G4UTSIKJTXBWDZUH7WVF7TFMWA","short_pith_number":"pith:G4UTSIKJ","canonical_record":{"source":{"id":"2106.12526","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"eess.IV","submitted_at":"2021-06-23T16:44:15Z","cross_cats_sorted":[],"title_canon_sha256":"e6b004c7bae86f3186f7dc0dc761f0f1e498b779a353e7b3c24a84fbc621ae46","abstract_canon_sha256":"e8da252309159470da7e0156318c86aa73904c018604fda1f28e52508dae177f"},"schema_version":"1.0"},"canonical_sha256":"37293921499dc361e687fdaa5fccacb02d63177e80966542a5e016bcd1be356f","source":{"kind":"arxiv","id":"2106.12526","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2106.12526","created_at":"2026-07-05T02:51:56Z"},{"alias_kind":"arxiv_version","alias_value":"2106.12526v1","created_at":"2026-07-05T02:51:56Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2106.12526","created_at":"2026-07-05T02:51:56Z"},{"alias_kind":"pith_short_12","alias_value":"G4UTSIKJTXBW","created_at":"2026-07-05T02:51:56Z"},{"alias_kind":"pith_short_16","alias_value":"G4UTSIKJTXBWDZUH","created_at":"2026-07-05T02:51:56Z"},{"alias_kind":"pith_short_8","alias_value":"G4UTSIKJ","created_at":"2026-07-05T02:51:56Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2021:G4UTSIKJTXBWDZUH7WVF7TFMWA","target":"record","payload":{"canonical_record":{"source":{"id":"2106.12526","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"eess.IV","submitted_at":"2021-06-23T16:44:15Z","cross_cats_sorted":[],"title_canon_sha256":"e6b004c7bae86f3186f7dc0dc761f0f1e498b779a353e7b3c24a84fbc621ae46","abstract_canon_sha256":"e8da252309159470da7e0156318c86aa73904c018604fda1f28e52508dae177f"},"schema_version":"1.0"},"canonical_sha256":"37293921499dc361e687fdaa5fccacb02d63177e80966542a5e016bcd1be356f","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T02:51:56.505130Z","signature_b64":"Tr/WZK91FSl2UEcUmHNdg5L+GuBrhN2XAP3BEXRj569fQFVvKUnuYiB42ingNaCQS/3VRpuinonYkeOS8YXBCA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"37293921499dc361e687fdaa5fccacb02d63177e80966542a5e016bcd1be356f","last_reissued_at":"2026-07-05T02:51:56.504696Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T02:51:56.504696Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2106.12526","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T02:51:56Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"dZtvdR+lH8xZTa6Kyf+2XL1VHCnLGvPkDRMw5NxGk2BzSKc1CO2u7BllV8DBqQx/DY7u74sHaekq4+PCRmBpAw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-04T10:22:40.657645Z"},"content_sha256":"1724d2bdef7e2f730b38151a685f5a9a93079e77c9ac0d11bdd513c6d88f1fe9","schema_version":"1.0","event_id":"sha256:1724d2bdef7e2f730b38151a685f5a9a93079e77c9ac0d11bdd513c6d88f1fe9"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2021:G4UTSIKJTXBWDZUH7WVF7TFMWA","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Weakly Supervised Registration of Prostate MRI and Histopathology Images","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","headline":"","cross_cats":[],"primary_cat":"eess.IV","authors_text":"Christian A. Kunder, Geoffrey A. Sonn, Indrani Bhattacharya, James D. Brooks, Jeffrey B. Wang, Mirabela Rusu, Pejman Ghanouni, Richard E. Fan, Simon J.C. Soerensen, Wei Shao","submitted_at":"2021-06-23T16:44:15Z","abstract_excerpt":"The interpretation of prostate MRI suffers from low agreement across radiologists due to the subtle differences between cancer and normal tissue. Image registration addresses this issue by accurately mapping the ground-truth cancer labels from surgical histopathology images onto MRI. Cancer labels achieved by image registration can be used to improve radiologists' interpretation of MRI by training deep learning models for early detection of prostate cancer. A major limitation of current automated registration approaches is that they require manual prostate segmentations, which is a time-consum"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2106.12526","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2106.12526/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T02:51:56Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"TcPHr/hTCzk6u+anAwfg9SEqhs1ERE8CERzcoAjgjAyWXlnA4+TnQOw75HSBInCMBLzPNKWZeHoMTR8axZGAAg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-04T10:22:40.658137Z"},"content_sha256":"a3aedbff0522f7513e105949e33217471006810d1d29837dc104c9915a98427f","schema_version":"1.0","event_id":"sha256:a3aedbff0522f7513e105949e33217471006810d1d29837dc104c9915a98427f"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/G4UTSIKJTXBWDZUH7WVF7TFMWA/bundle.json","state_url":"https://pith.science/pith/G4UTSIKJTXBWDZUH7WVF7TFMWA/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/G4UTSIKJTXBWDZUH7WVF7TFMWA/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-04T10:22:40Z","links":{"resolver":"https://pith.science/pith/G4UTSIKJTXBWDZUH7WVF7TFMWA","bundle":"https://pith.science/pith/G4UTSIKJTXBWDZUH7WVF7TFMWA/bundle.json","state":"https://pith.science/pith/G4UTSIKJTXBWDZUH7WVF7TFMWA/state.json","well_known_bundle":"https://pith.science/.well-known/pith/G4UTSIKJTXBWDZUH7WVF7TFMWA/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2021:G4UTSIKJTXBWDZUH7WVF7TFMWA","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"e8da252309159470da7e0156318c86aa73904c018604fda1f28e52508dae177f","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"eess.IV","submitted_at":"2021-06-23T16:44:15Z","title_canon_sha256":"e6b004c7bae86f3186f7dc0dc761f0f1e498b779a353e7b3c24a84fbc621ae46"},"schema_version":"1.0","source":{"id":"2106.12526","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2106.12526","created_at":"2026-07-05T02:51:56Z"},{"alias_kind":"arxiv_version","alias_value":"2106.12526v1","created_at":"2026-07-05T02:51:56Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2106.12526","created_at":"2026-07-05T02:51:56Z"},{"alias_kind":"pith_short_12","alias_value":"G4UTSIKJTXBW","created_at":"2026-07-05T02:51:56Z"},{"alias_kind":"pith_short_16","alias_value":"G4UTSIKJTXBWDZUH","created_at":"2026-07-05T02:51:56Z"},{"alias_kind":"pith_short_8","alias_value":"G4UTSIKJ","created_at":"2026-07-05T02:51:56Z"}],"graph_snapshots":[{"event_id":"sha256:a3aedbff0522f7513e105949e33217471006810d1d29837dc104c9915a98427f","target":"graph","created_at":"2026-07-05T02:51:56Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2106.12526/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"The interpretation of prostate MRI suffers from low agreement across radiologists due to the subtle differences between cancer and normal tissue. Image registration addresses this issue by accurately mapping the ground-truth cancer labels from surgical histopathology images onto MRI. Cancer labels achieved by image registration can be used to improve radiologists' interpretation of MRI by training deep learning models for early detection of prostate cancer. A major limitation of current automated registration approaches is that they require manual prostate segmentations, which is a time-consum","authors_text":"Christian A. Kunder, Geoffrey A. Sonn, Indrani Bhattacharya, James D. Brooks, Jeffrey B. Wang, Mirabela Rusu, Pejman Ghanouni, Richard E. Fan, Simon J.C. Soerensen, Wei Shao","cross_cats":[],"headline":"","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"eess.IV","submitted_at":"2021-06-23T16:44:15Z","title":"Weakly Supervised Registration of Prostate MRI and Histopathology Images"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2106.12526","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:1724d2bdef7e2f730b38151a685f5a9a93079e77c9ac0d11bdd513c6d88f1fe9","target":"record","created_at":"2026-07-05T02:51:56Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"e8da252309159470da7e0156318c86aa73904c018604fda1f28e52508dae177f","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"eess.IV","submitted_at":"2021-06-23T16:44:15Z","title_canon_sha256":"e6b004c7bae86f3186f7dc0dc761f0f1e498b779a353e7b3c24a84fbc621ae46"},"schema_version":"1.0","source":{"id":"2106.12526","kind":"arxiv","version":1}},"canonical_sha256":"37293921499dc361e687fdaa5fccacb02d63177e80966542a5e016bcd1be356f","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"37293921499dc361e687fdaa5fccacb02d63177e80966542a5e016bcd1be356f","first_computed_at":"2026-07-05T02:51:56.504696Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T02:51:56.504696Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"Tr/WZK91FSl2UEcUmHNdg5L+GuBrhN2XAP3BEXRj569fQFVvKUnuYiB42ingNaCQS/3VRpuinonYkeOS8YXBCA==","signature_status":"signed_v1","signed_at":"2026-07-05T02:51:56.505130Z","signed_message":"canonical_sha256_bytes"},"source_id":"2106.12526","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:1724d2bdef7e2f730b38151a685f5a9a93079e77c9ac0d11bdd513c6d88f1fe9","sha256:a3aedbff0522f7513e105949e33217471006810d1d29837dc104c9915a98427f"],"state_sha256":"fbe1a957f7349e90a6a9c056db9367ea32250350424d1d70c29a604405d441f3"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"KxleDhAioxubBm1874TtHsyOQFsd51Q21jndwCNOpyAqs6cNLDvHV0JUnE/tH42EvtNTM6P6xTMJGH40zM5+Cw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-04T10:22:40.661674Z","bundle_sha256":"97037f0445119ed16230ccbe29904ae9e41a5e0243dbbbbf70a0fa394d86c0d1"}}