{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2016:G66UD3W5BKBRCVUTQ6RAO7HJT2","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"35969bcf472368a00a73eb3e717f68971bfb8ef4700806f48c6e7b09ff98aea6","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2016-09-15T02:46:20Z","title_canon_sha256":"719e8f5d9378985a17788598e8f1b15d4ac2b5186461aecc4e7d43c1d54c9b0e"},"schema_version":"1.0","source":{"id":"1609.04496","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1609.04496","created_at":"2026-05-18T00:49:42Z"},{"alias_kind":"arxiv_version","alias_value":"1609.04496v2","created_at":"2026-05-18T00:49:42Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1609.04496","created_at":"2026-05-18T00:49:42Z"},{"alias_kind":"pith_short_12","alias_value":"G66UD3W5BKBR","created_at":"2026-05-18T12:30:15Z"},{"alias_kind":"pith_short_16","alias_value":"G66UD3W5BKBRCVUT","created_at":"2026-05-18T12:30:15Z"},{"alias_kind":"pith_short_8","alias_value":"G66UD3W5","created_at":"2026-05-18T12:30:15Z"}],"graph_snapshots":[{"event_id":"sha256:39c816e27277bc69ebe841df81bd1fa1feb2b5e362ae630012c14c48fdbaf835","target":"graph","created_at":"2026-05-18T00:49:42Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"The retinal pigment epithelium (RPE) is a key site of pathogenesis for many retina diseases. The formation of drusen in the retina is characteristic of retinal degeneration. We investigate morphological changes in the RPE in the presence of soft drusen using an integrated experimental and modeling approach. We collect RPE flat mount images from donated human eyes and develop 1) statistical tools to quantify the images and 2) a cell-based model to simulate the morphology evolution. We compare three different mechanisms of RPE repair evolution, cell apoptosis, cell fusion, and expansion, and Sim","authors_text":"F. Family, H. E. Grossniklaus, J. M. Nickerson, K. I. Mazzitello, M. A. Chrenek, Q. Zhang, Y. Jiang","cross_cats":["physics.bio-ph"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2016-09-15T02:46:20Z","title":"Druse-Induced Morphology Evolution in Retinal Pigment Epithelium"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1609.04496","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:e4f02497f1c5fc4a7ecb77e10883d38f09b3808648ed9bbfc52febba0d163c41","target":"record","created_at":"2026-05-18T00:49:42Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"35969bcf472368a00a73eb3e717f68971bfb8ef4700806f48c6e7b09ff98aea6","cross_cats_sorted":["physics.bio-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2016-09-15T02:46:20Z","title_canon_sha256":"719e8f5d9378985a17788598e8f1b15d4ac2b5186461aecc4e7d43c1d54c9b0e"},"schema_version":"1.0","source":{"id":"1609.04496","kind":"arxiv","version":2}},"canonical_sha256":"37bd41eedd0a8311569387a2077ce99eba9f96798bbbe0d8b4ddf32e36255d76","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"37bd41eedd0a8311569387a2077ce99eba9f96798bbbe0d8b4ddf32e36255d76","first_computed_at":"2026-05-18T00:49:42.133834Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:49:42.133834Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"REJIR+nyRYWYjXDziX5oZXS3cJ/nQB6lHwMaE2OzdpigpGHdbp+hRY6Gfd/hb35bns2ozV6AL7SdY9chaYjMCQ==","signature_status":"signed_v1","signed_at":"2026-05-18T00:49:42.134294Z","signed_message":"canonical_sha256_bytes"},"source_id":"1609.04496","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:e4f02497f1c5fc4a7ecb77e10883d38f09b3808648ed9bbfc52febba0d163c41","sha256:39c816e27277bc69ebe841df81bd1fa1feb2b5e362ae630012c14c48fdbaf835"],"state_sha256":"08ff2420a5b1742960a3524e160e9ad16b204ad3e5c862893ce1cde8df81fcb7"}