{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2014:G7F2VAOGS525LEELJNZ4JWZYNW","short_pith_number":"pith:G7F2VAOG","schema_version":"1.0","canonical_sha256":"37cbaa81c69775d5908b4b73c4db386d840b945e1dafe7dd4b96ff7e435a26bf","source":{"kind":"arxiv","id":"1408.1177","version":1},"attestation_state":"computed","paper":{"title":"Complex-based analysis of dysregulated cellular processes in cancer","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.MN","authors_text":"Chao Liu, Kum Kum Khanna, Mark A. Ragan, Peter T. Simpson, Piyush B. Madhamshettiwar, Sarah Song, Sriganesh Srihari","submitted_at":"2014-08-06T04:00:19Z","abstract_excerpt":"Background: Differential expression analysis of (individual) genes is often used to study their roles in diseases. However, diseases such as cancer are a result of the combined effect of multiple genes. Gene products such as proteins seldom act in isolation, but instead constitute stable multi-protein complexes performing dedicated functions. Therefore, complexes aggregate the effect of individual genes (proteins) and can be used to gain a better understanding of cancer mechanisms. Here, we observe that complexes show considerable changes in their expression, in turn directed by the concerted "},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1408.1177","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2014-08-06T04:00:19Z","cross_cats_sorted":[],"title_canon_sha256":"e111585d438fb265406a87744e03de0d0210d0d652098890979971c574eb40d6","abstract_canon_sha256":"179ff98392a21a9646489676f06a058d9c4d3967355032ef3e3a103f6e311d90"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T02:45:48.020635Z","signature_b64":"rFAN4fvSK1ucFh6aWZaMCeZSE/I2hsPIvBHuP8az5EGZ35Qrt/43kuP+HtmTin9dQZR+37YkMFbjaKBS+re5DA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"37cbaa81c69775d5908b4b73c4db386d840b945e1dafe7dd4b96ff7e435a26bf","last_reissued_at":"2026-05-18T02:45:48.020190Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T02:45:48.020190Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Complex-based analysis of dysregulated cellular processes in cancer","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.MN","authors_text":"Chao Liu, Kum Kum Khanna, Mark A. Ragan, Peter T. Simpson, Piyush B. Madhamshettiwar, Sarah Song, Sriganesh Srihari","submitted_at":"2014-08-06T04:00:19Z","abstract_excerpt":"Background: Differential expression analysis of (individual) genes is often used to study their roles in diseases. However, diseases such as cancer are a result of the combined effect of multiple genes. Gene products such as proteins seldom act in isolation, but instead constitute stable multi-protein complexes performing dedicated functions. Therefore, complexes aggregate the effect of individual genes (proteins) and can be used to gain a better understanding of cancer mechanisms. Here, we observe that complexes show considerable changes in their expression, in turn directed by the concerted "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1408.1177","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1408.1177","created_at":"2026-05-18T02:45:48.020254+00:00"},{"alias_kind":"arxiv_version","alias_value":"1408.1177v1","created_at":"2026-05-18T02:45:48.020254+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1408.1177","created_at":"2026-05-18T02:45:48.020254+00:00"},{"alias_kind":"pith_short_12","alias_value":"G7F2VAOGS525","created_at":"2026-05-18T12:28:28.263976+00:00"},{"alias_kind":"pith_short_16","alias_value":"G7F2VAOGS525LEEL","created_at":"2026-05-18T12:28:28.263976+00:00"},{"alias_kind":"pith_short_8","alias_value":"G7F2VAOG","created_at":"2026-05-18T12:28:28.263976+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/G7F2VAOGS525LEELJNZ4JWZYNW","json":"https://pith.science/pith/G7F2VAOGS525LEELJNZ4JWZYNW.json","graph_json":"https://pith.science/api/pith-number/G7F2VAOGS525LEELJNZ4JWZYNW/graph.json","events_json":"https://pith.science/api/pith-number/G7F2VAOGS525LEELJNZ4JWZYNW/events.json","paper":"https://pith.science/paper/G7F2VAOG"},"agent_actions":{"view_html":"https://pith.science/pith/G7F2VAOGS525LEELJNZ4JWZYNW","download_json":"https://pith.science/pith/G7F2VAOGS525LEELJNZ4JWZYNW.json","view_paper":"https://pith.science/paper/G7F2VAOG","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1408.1177&json=true","fetch_graph":"https://pith.science/api/pith-number/G7F2VAOGS525LEELJNZ4JWZYNW/graph.json","fetch_events":"https://pith.science/api/pith-number/G7F2VAOGS525LEELJNZ4JWZYNW/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/G7F2VAOGS525LEELJNZ4JWZYNW/action/timestamp_anchor","attest_storage":"https://pith.science/pith/G7F2VAOGS525LEELJNZ4JWZYNW/action/storage_attestation","attest_author":"https://pith.science/pith/G7F2VAOGS525LEELJNZ4JWZYNW/action/author_attestation","sign_citation":"https://pith.science/pith/G7F2VAOGS525LEELJNZ4JWZYNW/action/citation_signature","submit_replication":"https://pith.science/pith/G7F2VAOGS525LEELJNZ4JWZYNW/action/replication_record"}},"created_at":"2026-05-18T02:45:48.020254+00:00","updated_at":"2026-05-18T02:45:48.020254+00:00"}