{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2009:GBJAUNHAKV7XI6HK65WSPHCR3B","short_pith_number":"pith:GBJAUNHA","canonical_record":{"source":{"id":"0909.1918","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.SC","submitted_at":"2009-09-10T10:44:41Z","cross_cats_sorted":[],"title_canon_sha256":"989ff9c274afa4b410c4f5a8a1c2c46a2241dcd0da1de8b7ce2f607b8b1ada05","abstract_canon_sha256":"e96777d646bb41f09a6b839682abf31538e40f0c1184399b4c170ee463a2bf2d"},"schema_version":"1.0"},"canonical_sha256":"30520a34e0557f7478eaf76d279c51d87f95efc64aa75c61578447a8aa3de44c","source":{"kind":"arxiv","id":"0909.1918","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"0909.1918","created_at":"2026-05-18T02:11:57Z"},{"alias_kind":"arxiv_version","alias_value":"0909.1918v1","created_at":"2026-05-18T02:11:57Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.0909.1918","created_at":"2026-05-18T02:11:57Z"},{"alias_kind":"pith_short_12","alias_value":"GBJAUNHAKV7X","created_at":"2026-05-18T12:25:59Z"},{"alias_kind":"pith_short_16","alias_value":"GBJAUNHAKV7XI6HK","created_at":"2026-05-18T12:25:59Z"},{"alias_kind":"pith_short_8","alias_value":"GBJAUNHA","created_at":"2026-05-18T12:25:59Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2009:GBJAUNHAKV7XI6HK65WSPHCR3B","target":"record","payload":{"canonical_record":{"source":{"id":"0909.1918","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.SC","submitted_at":"2009-09-10T10:44:41Z","cross_cats_sorted":[],"title_canon_sha256":"989ff9c274afa4b410c4f5a8a1c2c46a2241dcd0da1de8b7ce2f607b8b1ada05","abstract_canon_sha256":"e96777d646bb41f09a6b839682abf31538e40f0c1184399b4c170ee463a2bf2d"},"schema_version":"1.0"},"canonical_sha256":"30520a34e0557f7478eaf76d279c51d87f95efc64aa75c61578447a8aa3de44c","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T02:11:57.551962Z","signature_b64":"R/j7kn5l+CwDnmalw0jd7h+z81UuynyTzxIDjo878ggMveCOgNQHwzOGkyAvQYEX/dSUbqUB+AxRy262SZivAA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"30520a34e0557f7478eaf76d279c51d87f95efc64aa75c61578447a8aa3de44c","last_reissued_at":"2026-05-18T02:11:57.551175Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T02:11:57.551175Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"0909.1918","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:11:57Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"MU3YHdn2Yt41v+O/RDT6Tyyj6vNssoTcNyUsr2NwSsdtvocKwvM/02GHJTFL1B7uNFI6/LpW1cCzVQa5fChNBg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-08T16:46:19.556552Z"},"content_sha256":"bcc1093c8cb815f155f68271a41c8600664de30973273f8cf8341840e1d5b917","schema_version":"1.0","event_id":"sha256:bcc1093c8cb815f155f68271a41c8600664de30973273f8cf8341840e1d5b917"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2009:GBJAUNHAKV7XI6HK65WSPHCR3B","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Dynamics of intracellular Ca$^{2+}$ oscillations in the presence of multisite Ca$^{2+}$-binding proteins","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.SC","authors_text":"Alessio Del Fabbro, Edoardo Milotti, Roberto Chignola","submitted_at":"2009-09-10T10:44:41Z","abstract_excerpt":"We study the dynamics of intracellular calcium oscillations in the presence of proteins that bind calcium on multiple sites and that are generally believed to act as passive calcium buffers in cells. We find that multisite calcium-binding proteins set a sharp threshold for calcium oscillations. Even with high concentrations of calcium-binding proteins, internal noise, which shows up spontaneously in cells in the process of calcium wave formation, can lead to self-oscillations. This produces oscillatory behaviors strikingly similar to those observed in real cells. In addition, for given intrace"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"0909.1918","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:11:57Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Kfqnt1jGv8ZOKrp+vOIFRHQ1RFNCDIGJzNgOETnJ5Up78X5eIXRkSqg1WX6FKYKmaAjNmAnu48MNejIEN6j9Cg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-08T16:46:19.557273Z"},"content_sha256":"19f4282927aa198a7759ae8ebdfd7ea0c2d5feeb60628f5de5471083615752a3","schema_version":"1.0","event_id":"sha256:19f4282927aa198a7759ae8ebdfd7ea0c2d5feeb60628f5de5471083615752a3"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/GBJAUNHAKV7XI6HK65WSPHCR3B/bundle.json","state_url":"https://pith.science/pith/GBJAUNHAKV7XI6HK65WSPHCR3B/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/GBJAUNHAKV7XI6HK65WSPHCR3B/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-08T16:46:19Z","links":{"resolver":"https://pith.science/pith/GBJAUNHAKV7XI6HK65WSPHCR3B","bundle":"https://pith.science/pith/GBJAUNHAKV7XI6HK65WSPHCR3B/bundle.json","state":"https://pith.science/pith/GBJAUNHAKV7XI6HK65WSPHCR3B/state.json","well_known_bundle":"https://pith.science/.well-known/pith/GBJAUNHAKV7XI6HK65WSPHCR3B/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2009:GBJAUNHAKV7XI6HK65WSPHCR3B","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"e96777d646bb41f09a6b839682abf31538e40f0c1184399b4c170ee463a2bf2d","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.SC","submitted_at":"2009-09-10T10:44:41Z","title_canon_sha256":"989ff9c274afa4b410c4f5a8a1c2c46a2241dcd0da1de8b7ce2f607b8b1ada05"},"schema_version":"1.0","source":{"id":"0909.1918","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"0909.1918","created_at":"2026-05-18T02:11:57Z"},{"alias_kind":"arxiv_version","alias_value":"0909.1918v1","created_at":"2026-05-18T02:11:57Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.0909.1918","created_at":"2026-05-18T02:11:57Z"},{"alias_kind":"pith_short_12","alias_value":"GBJAUNHAKV7X","created_at":"2026-05-18T12:25:59Z"},{"alias_kind":"pith_short_16","alias_value":"GBJAUNHAKV7XI6HK","created_at":"2026-05-18T12:25:59Z"},{"alias_kind":"pith_short_8","alias_value":"GBJAUNHA","created_at":"2026-05-18T12:25:59Z"}],"graph_snapshots":[{"event_id":"sha256:19f4282927aa198a7759ae8ebdfd7ea0c2d5feeb60628f5de5471083615752a3","target":"graph","created_at":"2026-05-18T02:11:57Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"We study the dynamics of intracellular calcium oscillations in the presence of proteins that bind calcium on multiple sites and that are generally believed to act as passive calcium buffers in cells. We find that multisite calcium-binding proteins set a sharp threshold for calcium oscillations. Even with high concentrations of calcium-binding proteins, internal noise, which shows up spontaneously in cells in the process of calcium wave formation, can lead to self-oscillations. This produces oscillatory behaviors strikingly similar to those observed in real cells. In addition, for given intrace","authors_text":"Alessio Del Fabbro, Edoardo Milotti, Roberto Chignola","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.SC","submitted_at":"2009-09-10T10:44:41Z","title":"Dynamics of intracellular Ca$^{2+}$ oscillations in the presence of multisite Ca$^{2+}$-binding proteins"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"0909.1918","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:bcc1093c8cb815f155f68271a41c8600664de30973273f8cf8341840e1d5b917","target":"record","created_at":"2026-05-18T02:11:57Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"e96777d646bb41f09a6b839682abf31538e40f0c1184399b4c170ee463a2bf2d","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.SC","submitted_at":"2009-09-10T10:44:41Z","title_canon_sha256":"989ff9c274afa4b410c4f5a8a1c2c46a2241dcd0da1de8b7ce2f607b8b1ada05"},"schema_version":"1.0","source":{"id":"0909.1918","kind":"arxiv","version":1}},"canonical_sha256":"30520a34e0557f7478eaf76d279c51d87f95efc64aa75c61578447a8aa3de44c","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"30520a34e0557f7478eaf76d279c51d87f95efc64aa75c61578447a8aa3de44c","first_computed_at":"2026-05-18T02:11:57.551175Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T02:11:57.551175Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"R/j7kn5l+CwDnmalw0jd7h+z81UuynyTzxIDjo878ggMveCOgNQHwzOGkyAvQYEX/dSUbqUB+AxRy262SZivAA==","signature_status":"signed_v1","signed_at":"2026-05-18T02:11:57.551962Z","signed_message":"canonical_sha256_bytes"},"source_id":"0909.1918","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:bcc1093c8cb815f155f68271a41c8600664de30973273f8cf8341840e1d5b917","sha256:19f4282927aa198a7759ae8ebdfd7ea0c2d5feeb60628f5de5471083615752a3"],"state_sha256":"6c18f10786f75d4be371993f884ccf896b7e59bcb60ce81827af0664daeb6064"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"+B8PAlmBPKIeGhS/SYQZNLAZY7N0wyhZfriBrpK97IcdrgdOD8tu+o8nyevWcIX++t3FGISp6bdBgfOpjX4vAQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-08T16:46:19.561275Z","bundle_sha256":"c16c97a1e713416805bd506c8ccb7782f976bd49ad33693c4fc7099ef1a62045"}}