{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2025:GEMWTSM4GWVPZ5FPZNDQIKQ7CJ","short_pith_number":"pith:GEMWTSM4","canonical_record":{"source":{"id":"2504.03876","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2025-04-04T19:01:17Z","cross_cats_sorted":["q-bio.GN"],"title_canon_sha256":"328adbf8ede99054c04ff5fc516c76096ed6128101b2568e4499504da230369d","abstract_canon_sha256":"0863e29538c85197e6cbabc428b087090d6ae82910e17349ab112ac9843162be"},"schema_version":"1.0"},"canonical_sha256":"311969c99c35aafcf4afcb47042a1f125109b0a49663682cb2cef19347374d51","source":{"kind":"arxiv","id":"2504.03876","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2504.03876","created_at":"2026-07-05T10:44:50Z"},{"alias_kind":"arxiv_version","alias_value":"2504.03876v1","created_at":"2026-07-05T10:44:50Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2504.03876","created_at":"2026-07-05T10:44:50Z"},{"alias_kind":"pith_short_12","alias_value":"GEMWTSM4GWVP","created_at":"2026-07-05T10:44:50Z"},{"alias_kind":"pith_short_16","alias_value":"GEMWTSM4GWVPZ5FP","created_at":"2026-07-05T10:44:50Z"},{"alias_kind":"pith_short_8","alias_value":"GEMWTSM4","created_at":"2026-07-05T10:44:50Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2025:GEMWTSM4GWVPZ5FPZNDQIKQ7CJ","target":"record","payload":{"canonical_record":{"source":{"id":"2504.03876","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2025-04-04T19:01:17Z","cross_cats_sorted":["q-bio.GN"],"title_canon_sha256":"328adbf8ede99054c04ff5fc516c76096ed6128101b2568e4499504da230369d","abstract_canon_sha256":"0863e29538c85197e6cbabc428b087090d6ae82910e17349ab112ac9843162be"},"schema_version":"1.0"},"canonical_sha256":"311969c99c35aafcf4afcb47042a1f125109b0a49663682cb2cef19347374d51","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T10:44:50.224990Z","signature_b64":"YEIe7Zu/DRdGfui9hsqEusRNkLyd5gexzAYmoj5Ii+ows3/JVMgI1Xe+tFIj3Jz+Cc2Cxio4zAwtZRHvg/fZDA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"311969c99c35aafcf4afcb47042a1f125109b0a49663682cb2cef19347374d51","last_reissued_at":"2026-07-05T10:44:50.224521Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T10:44:50.224521Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2504.03876","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T10:44:50Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"8c7Z4bJvQTPgCm1jjv1QBBhxgo5gRCY4hCsKe4JRjV3q1GtzDsvYyUMCFNhKEEXMXKLrecnMLcjYb+8o8+b1BA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-20T07:19:12.452931Z"},"content_sha256":"5ba94c26b6887c37940e871588aea3dedb3a85a6ffbf51b1b81e723a6c82e037","schema_version":"1.0","event_id":"sha256:5ba94c26b6887c37940e871588aea3dedb3a85a6ffbf51b1b81e723a6c82e037"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2025:GEMWTSM4GWVPZ5FPZNDQIKQ7CJ","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Multiscale Modeling Primer: Focus on Chromatin and Epigenetics","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.GN"],"primary_cat":"q-bio.MN","authors_text":"Achal Mahajan, Carlos F Lopez, Erik J. Navarro, William Poole","submitted_at":"2025-04-04T19:01:17Z","abstract_excerpt":"Essential life processes take place across multiple space and time scales in living organisms but understanding their mechanistic interactions remains an ongoing challenge. Advanced multiscale modeling techniques are providing new opportunities and insights into these complex processes. In cells, meters of chromatin are folded into a nucleus with a diameter on the order of microns. The three-dimensional chromatin structure coupled with biochemical processes that turn genes on or off, specify a given cell type through a complicated set of interactions collectively referred to as epigenetics. Im"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2504.03876","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2504.03876/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T10:44:50Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"dDeZjeD9e6SxfEldytnYjJ+ieOSI7XQOJGUyWIpXMnBFJEy2+cQv4kwCc3p2nPVUiEHQsttaKAXlfSjSrVKuAQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-20T07:19:12.453334Z"},"content_sha256":"ea4bde1452f605699d1902a465228d8c215cc8f7d2f1134d70b91404f52109ce","schema_version":"1.0","event_id":"sha256:ea4bde1452f605699d1902a465228d8c215cc8f7d2f1134d70b91404f52109ce"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/GEMWTSM4GWVPZ5FPZNDQIKQ7CJ/bundle.json","state_url":"https://pith.science/pith/GEMWTSM4GWVPZ5FPZNDQIKQ7CJ/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/GEMWTSM4GWVPZ5FPZNDQIKQ7CJ/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-20T07:19:12Z","links":{"resolver":"https://pith.science/pith/GEMWTSM4GWVPZ5FPZNDQIKQ7CJ","bundle":"https://pith.science/pith/GEMWTSM4GWVPZ5FPZNDQIKQ7CJ/bundle.json","state":"https://pith.science/pith/GEMWTSM4GWVPZ5FPZNDQIKQ7CJ/state.json","well_known_bundle":"https://pith.science/.well-known/pith/GEMWTSM4GWVPZ5FPZNDQIKQ7CJ/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:GEMWTSM4GWVPZ5FPZNDQIKQ7CJ","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"0863e29538c85197e6cbabc428b087090d6ae82910e17349ab112ac9843162be","cross_cats_sorted":["q-bio.GN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2025-04-04T19:01:17Z","title_canon_sha256":"328adbf8ede99054c04ff5fc516c76096ed6128101b2568e4499504da230369d"},"schema_version":"1.0","source":{"id":"2504.03876","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2504.03876","created_at":"2026-07-05T10:44:50Z"},{"alias_kind":"arxiv_version","alias_value":"2504.03876v1","created_at":"2026-07-05T10:44:50Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2504.03876","created_at":"2026-07-05T10:44:50Z"},{"alias_kind":"pith_short_12","alias_value":"GEMWTSM4GWVP","created_at":"2026-07-05T10:44:50Z"},{"alias_kind":"pith_short_16","alias_value":"GEMWTSM4GWVPZ5FP","created_at":"2026-07-05T10:44:50Z"},{"alias_kind":"pith_short_8","alias_value":"GEMWTSM4","created_at":"2026-07-05T10:44:50Z"}],"graph_snapshots":[{"event_id":"sha256:ea4bde1452f605699d1902a465228d8c215cc8f7d2f1134d70b91404f52109ce","target":"graph","created_at":"2026-07-05T10:44:50Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2504.03876/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Essential life processes take place across multiple space and time scales in living organisms but understanding their mechanistic interactions remains an ongoing challenge. Advanced multiscale modeling techniques are providing new opportunities and insights into these complex processes. In cells, meters of chromatin are folded into a nucleus with a diameter on the order of microns. The three-dimensional chromatin structure coupled with biochemical processes that turn genes on or off, specify a given cell type through a complicated set of interactions collectively referred to as epigenetics. Im","authors_text":"Achal Mahajan, Carlos F Lopez, Erik J. Navarro, William Poole","cross_cats":["q-bio.GN"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2025-04-04T19:01:17Z","title":"Multiscale Modeling Primer: Focus on Chromatin and Epigenetics"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2504.03876","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:5ba94c26b6887c37940e871588aea3dedb3a85a6ffbf51b1b81e723a6c82e037","target":"record","created_at":"2026-07-05T10:44:50Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"0863e29538c85197e6cbabc428b087090d6ae82910e17349ab112ac9843162be","cross_cats_sorted":["q-bio.GN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2025-04-04T19:01:17Z","title_canon_sha256":"328adbf8ede99054c04ff5fc516c76096ed6128101b2568e4499504da230369d"},"schema_version":"1.0","source":{"id":"2504.03876","kind":"arxiv","version":1}},"canonical_sha256":"311969c99c35aafcf4afcb47042a1f125109b0a49663682cb2cef19347374d51","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"311969c99c35aafcf4afcb47042a1f125109b0a49663682cb2cef19347374d51","first_computed_at":"2026-07-05T10:44:50.224521Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T10:44:50.224521Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"YEIe7Zu/DRdGfui9hsqEusRNkLyd5gexzAYmoj5Ii+ows3/JVMgI1Xe+tFIj3Jz+Cc2Cxio4zAwtZRHvg/fZDA==","signature_status":"signed_v1","signed_at":"2026-07-05T10:44:50.224990Z","signed_message":"canonical_sha256_bytes"},"source_id":"2504.03876","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:5ba94c26b6887c37940e871588aea3dedb3a85a6ffbf51b1b81e723a6c82e037","sha256:ea4bde1452f605699d1902a465228d8c215cc8f7d2f1134d70b91404f52109ce"],"state_sha256":"951b056a5374f9fd75b2c248549f7f04364e6bc9f7f119f56773653fe1718701"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"ax8IEJmhd/bwL6Vl+5Jd8F7lt61H6r5/jSiQnG9V6VJPIxeg6ANsZe+yXnViJ+hSoPJcsP4F/AraM0u9g3mxBA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-20T07:19:12.456009Z","bundle_sha256":"7581cbc89505da3482dbbcab199d10e9d04534782ff3a35d950495b2c70ec7ff"}}