{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2015:GFGMWGTHTEPFGZQD33IHXJKT65","short_pith_number":"pith:GFGMWGTH","canonical_record":{"source":{"id":"1510.02323","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2015-07-13T08:57:24Z","cross_cats_sorted":[],"title_canon_sha256":"85c99cdb3f27c1817b6485e5af0ef98c9b0fefa7eb9945de8292af44c5818d07","abstract_canon_sha256":"cf9f2c4f362e9fa0319703bf7e4fc82331d4790fc0c5af7565ad9c191f349c24"},"schema_version":"1.0"},"canonical_sha256":"314ccb1a67991e536603ded07ba553f7615702cbea12e6ad6cacd54da22b1e4d","source":{"kind":"arxiv","id":"1510.02323","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1510.02323","created_at":"2026-05-18T01:30:44Z"},{"alias_kind":"arxiv_version","alias_value":"1510.02323v1","created_at":"2026-05-18T01:30:44Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1510.02323","created_at":"2026-05-18T01:30:44Z"},{"alias_kind":"pith_short_12","alias_value":"GFGMWGTHTEPF","created_at":"2026-05-18T12:29:22Z"},{"alias_kind":"pith_short_16","alias_value":"GFGMWGTHTEPFGZQD","created_at":"2026-05-18T12:29:22Z"},{"alias_kind":"pith_short_8","alias_value":"GFGMWGTH","created_at":"2026-05-18T12:29:22Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2015:GFGMWGTHTEPFGZQD33IHXJKT65","target":"record","payload":{"canonical_record":{"source":{"id":"1510.02323","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2015-07-13T08:57:24Z","cross_cats_sorted":[],"title_canon_sha256":"85c99cdb3f27c1817b6485e5af0ef98c9b0fefa7eb9945de8292af44c5818d07","abstract_canon_sha256":"cf9f2c4f362e9fa0319703bf7e4fc82331d4790fc0c5af7565ad9c191f349c24"},"schema_version":"1.0"},"canonical_sha256":"314ccb1a67991e536603ded07ba553f7615702cbea12e6ad6cacd54da22b1e4d","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:30:44.087684Z","signature_b64":"4j/luGLmRCH/J+ksR+lymlNzo+/AA23ejX9UjkCwMd9JKNfuQE1yILbT1wsTQhchfvx0PmfC1v4tyPG5SDPWBA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"314ccb1a67991e536603ded07ba553f7615702cbea12e6ad6cacd54da22b1e4d","last_reissued_at":"2026-05-18T01:30:44.087037Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:30:44.087037Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1510.02323","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:30:44Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"SXj468dd8lGU3EN0MuEiXbdAkoRru2CAbYWfz2ZGfot+nu7XhmmUWHtLM5naPG97jZJ/HXjlj+Tx8n1VC9YkCQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-27T21:35:04.720779Z"},"content_sha256":"b3b2aa209c55fcba1f5cc579cb48b289c3a00dd4c165d9b3bab95faf633d1442","schema_version":"1.0","event_id":"sha256:b3b2aa209c55fcba1f5cc579cb48b289c3a00dd4c165d9b3bab95faf633d1442"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2015:GFGMWGTHTEPFGZQD33IHXJKT65","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Tumor-induced neoneurogenesis and perineural tumor growth: a mathematical approach","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.TO","authors_text":"Arianna Bianchi, Georgios Lolas, Konstantinos Syrigos","submitted_at":"2015-07-13T08:57:24Z","abstract_excerpt":"Primary tumors infrequently lead to demise of cancer patients; instead, mortality and a significant degree of morbidity result from the growth of secondary tumors in distant organs (metastasis). It is well-known that malignant tumors induce the formation of a lymphatic and a blood vascular network around themselves. A similar but far less studied process occurs in relation to the nervous system and is referred to as \\emph{neoneurogenesis}; in fact, recent studies have demonstrated that tumors initiate their own innervation. However, the relationship between tumor progression and the nervous sy"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1510.02323","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:30:44Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"sriGVYzP9nlyoTy8//trbpXc8kIP/D65iSdKZaokr1D+lAW+Ll+EJn5tYzMvsRr88TpNdB+U9wM0jFquOR/pDw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-27T21:35:04.721440Z"},"content_sha256":"c144829c649ae9169449a32bda79e4766c2f69b3f1e7f7317c8d7c5435647b25","schema_version":"1.0","event_id":"sha256:c144829c649ae9169449a32bda79e4766c2f69b3f1e7f7317c8d7c5435647b25"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/GFGMWGTHTEPFGZQD33IHXJKT65/bundle.json","state_url":"https://pith.science/pith/GFGMWGTHTEPFGZQD33IHXJKT65/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/GFGMWGTHTEPFGZQD33IHXJKT65/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-27T21:35:04Z","links":{"resolver":"https://pith.science/pith/GFGMWGTHTEPFGZQD33IHXJKT65","bundle":"https://pith.science/pith/GFGMWGTHTEPFGZQD33IHXJKT65/bundle.json","state":"https://pith.science/pith/GFGMWGTHTEPFGZQD33IHXJKT65/state.json","well_known_bundle":"https://pith.science/.well-known/pith/GFGMWGTHTEPFGZQD33IHXJKT65/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2015:GFGMWGTHTEPFGZQD33IHXJKT65","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"cf9f2c4f362e9fa0319703bf7e4fc82331d4790fc0c5af7565ad9c191f349c24","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2015-07-13T08:57:24Z","title_canon_sha256":"85c99cdb3f27c1817b6485e5af0ef98c9b0fefa7eb9945de8292af44c5818d07"},"schema_version":"1.0","source":{"id":"1510.02323","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1510.02323","created_at":"2026-05-18T01:30:44Z"},{"alias_kind":"arxiv_version","alias_value":"1510.02323v1","created_at":"2026-05-18T01:30:44Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1510.02323","created_at":"2026-05-18T01:30:44Z"},{"alias_kind":"pith_short_12","alias_value":"GFGMWGTHTEPF","created_at":"2026-05-18T12:29:22Z"},{"alias_kind":"pith_short_16","alias_value":"GFGMWGTHTEPFGZQD","created_at":"2026-05-18T12:29:22Z"},{"alias_kind":"pith_short_8","alias_value":"GFGMWGTH","created_at":"2026-05-18T12:29:22Z"}],"graph_snapshots":[{"event_id":"sha256:c144829c649ae9169449a32bda79e4766c2f69b3f1e7f7317c8d7c5435647b25","target":"graph","created_at":"2026-05-18T01:30:44Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Primary tumors infrequently lead to demise of cancer patients; instead, mortality and a significant degree of morbidity result from the growth of secondary tumors in distant organs (metastasis). It is well-known that malignant tumors induce the formation of a lymphatic and a blood vascular network around themselves. A similar but far less studied process occurs in relation to the nervous system and is referred to as \\emph{neoneurogenesis}; in fact, recent studies have demonstrated that tumors initiate their own innervation. However, the relationship between tumor progression and the nervous sy","authors_text":"Arianna Bianchi, Georgios Lolas, Konstantinos Syrigos","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2015-07-13T08:57:24Z","title":"Tumor-induced neoneurogenesis and perineural tumor growth: a mathematical approach"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1510.02323","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:b3b2aa209c55fcba1f5cc579cb48b289c3a00dd4c165d9b3bab95faf633d1442","target":"record","created_at":"2026-05-18T01:30:44Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"cf9f2c4f362e9fa0319703bf7e4fc82331d4790fc0c5af7565ad9c191f349c24","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2015-07-13T08:57:24Z","title_canon_sha256":"85c99cdb3f27c1817b6485e5af0ef98c9b0fefa7eb9945de8292af44c5818d07"},"schema_version":"1.0","source":{"id":"1510.02323","kind":"arxiv","version":1}},"canonical_sha256":"314ccb1a67991e536603ded07ba553f7615702cbea12e6ad6cacd54da22b1e4d","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"314ccb1a67991e536603ded07ba553f7615702cbea12e6ad6cacd54da22b1e4d","first_computed_at":"2026-05-18T01:30:44.087037Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:30:44.087037Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"4j/luGLmRCH/J+ksR+lymlNzo+/AA23ejX9UjkCwMd9JKNfuQE1yILbT1wsTQhchfvx0PmfC1v4tyPG5SDPWBA==","signature_status":"signed_v1","signed_at":"2026-05-18T01:30:44.087684Z","signed_message":"canonical_sha256_bytes"},"source_id":"1510.02323","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:b3b2aa209c55fcba1f5cc579cb48b289c3a00dd4c165d9b3bab95faf633d1442","sha256:c144829c649ae9169449a32bda79e4766c2f69b3f1e7f7317c8d7c5435647b25"],"state_sha256":"f742399a73145a31120baa22f066dea4d1a9aaec3ec1da1099c293a01b294d46"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Ja1J7UvIkbkTM5ve2/NWyo4lzaFCvfwEKy9Bf/jMDE+t0d7LDyanxaP8PMwB2wGzHd3O/p7r6xwSadrxT3pPAg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-27T21:35:04.724775Z","bundle_sha256":"85c7f700db9711705b85ac71da2c0dacf5675439f0c888ce5ee628b94715e6d7"}}