{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2015:GJCCEF7VRR6O4EJDF77ZUWINJM","short_pith_number":"pith:GJCCEF7V","schema_version":"1.0","canonical_sha256":"32442217f58c7cee11232fff9a590d4b3e82589912f04c1f44adfbcf29a7530b","source":{"kind":"arxiv","id":"1504.02494","version":1},"attestation_state":"computed","paper":{"title":"Thermodynamics of accuracy in kinetic proofreading: Dissipation and efficiency trade-offs","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph","q-bio.SC"],"primary_cat":"cond-mat.stat-mech","authors_text":"Luca Peliti, Riccardo Rao","submitted_at":"2015-04-09T20:47:34Z","abstract_excerpt":"The high accuracy exhibited by biological information transcription processes is due to kinetic proofreading, i.e., by a mechanism which reduces the error rate of the information-handling process by driving it out of equilibrium. We provide a consistent thermodynamic description of enzyme-assisted assembly processes involving competing substrates, in a Master Equation framework. We introduce and evaluate a measure of the efficiency based on rigorous non-equilibrium inequalities. The performance of several proofreading models are thus analyzed and the related time, dissipation and efficiency vs"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1504.02494","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cond-mat.stat-mech","submitted_at":"2015-04-09T20:47:34Z","cross_cats_sorted":["physics.bio-ph","q-bio.SC"],"title_canon_sha256":"1b898ce3fffd0c0305c378af92009561252770e26d926dcbb644274d92ac8f46","abstract_canon_sha256":"f8b5d8216045d15dd5f0e6213840a38c7be2bfc88b272c04e1454c8bed4670b2"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:46:13.361103Z","signature_b64":"z2sdqmWCHlVApygaQyFEEfcvq6quhp/3wIyDEr8uiwqAnXxTOLmjPendN4ymObzOLnsR1ir4DtZlC7wcwj2fAA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"32442217f58c7cee11232fff9a590d4b3e82589912f04c1f44adfbcf29a7530b","last_reissued_at":"2026-05-18T01:46:13.360339Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:46:13.360339Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Thermodynamics of accuracy in kinetic proofreading: Dissipation and efficiency trade-offs","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph","q-bio.SC"],"primary_cat":"cond-mat.stat-mech","authors_text":"Luca Peliti, Riccardo Rao","submitted_at":"2015-04-09T20:47:34Z","abstract_excerpt":"The high accuracy exhibited by biological information transcription processes is due to kinetic proofreading, i.e., by a mechanism which reduces the error rate of the information-handling process by driving it out of equilibrium. We provide a consistent thermodynamic description of enzyme-assisted assembly processes involving competing substrates, in a Master Equation framework. We introduce and evaluate a measure of the efficiency based on rigorous non-equilibrium inequalities. The performance of several proofreading models are thus analyzed and the related time, dissipation and efficiency vs"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1504.02494","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1504.02494","created_at":"2026-05-18T01:46:13.360482+00:00"},{"alias_kind":"arxiv_version","alias_value":"1504.02494v1","created_at":"2026-05-18T01:46:13.360482+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1504.02494","created_at":"2026-05-18T01:46:13.360482+00:00"},{"alias_kind":"pith_short_12","alias_value":"GJCCEF7VRR6O","created_at":"2026-05-18T12:29:22.688609+00:00"},{"alias_kind":"pith_short_16","alias_value":"GJCCEF7VRR6O4EJD","created_at":"2026-05-18T12:29:22.688609+00:00"},{"alias_kind":"pith_short_8","alias_value":"GJCCEF7V","created_at":"2026-05-18T12:29:22.688609+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/GJCCEF7VRR6O4EJDF77ZUWINJM","json":"https://pith.science/pith/GJCCEF7VRR6O4EJDF77ZUWINJM.json","graph_json":"https://pith.science/api/pith-number/GJCCEF7VRR6O4EJDF77ZUWINJM/graph.json","events_json":"https://pith.science/api/pith-number/GJCCEF7VRR6O4EJDF77ZUWINJM/events.json","paper":"https://pith.science/paper/GJCCEF7V"},"agent_actions":{"view_html":"https://pith.science/pith/GJCCEF7VRR6O4EJDF77ZUWINJM","download_json":"https://pith.science/pith/GJCCEF7VRR6O4EJDF77ZUWINJM.json","view_paper":"https://pith.science/paper/GJCCEF7V","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1504.02494&json=true","fetch_graph":"https://pith.science/api/pith-number/GJCCEF7VRR6O4EJDF77ZUWINJM/graph.json","fetch_events":"https://pith.science/api/pith-number/GJCCEF7VRR6O4EJDF77ZUWINJM/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/GJCCEF7VRR6O4EJDF77ZUWINJM/action/timestamp_anchor","attest_storage":"https://pith.science/pith/GJCCEF7VRR6O4EJDF77ZUWINJM/action/storage_attestation","attest_author":"https://pith.science/pith/GJCCEF7VRR6O4EJDF77ZUWINJM/action/author_attestation","sign_citation":"https://pith.science/pith/GJCCEF7VRR6O4EJDF77ZUWINJM/action/citation_signature","submit_replication":"https://pith.science/pith/GJCCEF7VRR6O4EJDF77ZUWINJM/action/replication_record"}},"created_at":"2026-05-18T01:46:13.360482+00:00","updated_at":"2026-05-18T01:46:13.360482+00:00"}